dbPTM

DDAH2_RAT - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DDAH2_RAT
UniProt AC	Q6MG60
Protein Name	N(G),N(G)-dimethylarginine dimethylaminohydrolase 2
Gene Name	Ddah2
Organism	Rattus norvegicus (Rat).
Sequence Length	285
Subcellular Localization	Cytoplasm. Mitochondrion. Translocates from cytosol to mitochondrion upon IL-1beta stimulation in chondrocytes..
Protein Description	Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation (By similarity)..
Protein Sequence	MGTPGEGLGRCSHALIRGVPESLASGEGAGAGLPALDLAKAQREHGVLGGKLRQRLGLQLLELPPEESLPLGPLLGDTAVIQGDTALITRPWSPARRPEVDGVRKALQDLGLRIVEMGDENATLDGTDVLFTGREFFVGLSKWTNHRGAEIVADTFRDFAVSTVPVSGASHLRGLCGMGGPRTVVAGSSEAAQKAVRAMAALTDHPYASLTLPDDAASDCLFLRPGLPGTTPFLLHRGGGDLPNSQEALQKLSDVTLVPVSCSELEKVGAGLSSLCLVLSTRPHC

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MGTPGEGLGR -----CCCCCCCCCH	27.16	22673903
40	Acetylation	LPALDLAKAQREHGV CCHHHHHHHHHHHCC	52.96	22902405
51	Acetylation	EHGVLGGKLRQRLGL HHCCCCHHHHHHHCC	38.40	22902405
105	Ubiquitination	PEVDGVRKALQDLGL CCCCHHHHHHHHHCC	51.55	-
194	Ubiquitination	GSSEAAQKAVRAMAA CCHHHHHHHHHHHHH	44.09	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of DDAH2_RAT !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DDAH2_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DDAH2_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of DDAH2_RAT !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DDAH2_RAT

Related Literatures of Post-Translational Modification