DDAH1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DDAH1_MOUSE
• UniProt AC: Q9CWS0
• Protein Name: N(G),N(G)-dimethylarginine dimethylaminohydrolase 1
• Gene Name: Ddah1
• Organism: Mus musculus (Mouse).
• Sequence Length: 285
• Protein Description: Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation..
• Protein Sequence: MAGLGHPSAFGRATHAVVRAPPESLCRHALRRSQGEEVDFARAERQHELYVGVLGSKLGLQVVQLPADESLPDCVFVEDVAVVCEETALITRPGAPSRRKEVDMMKEALEKLQLNIVEMKDENATLDGGDVLFTGREFFVGLSKRTNQRGAEILADTFKDYAVSTVPVADSLHLKSFCSMAGPNLIAIGSSESAQKALKIMQQMSDHRYDKLTVPDDMAANCIYLNIPSKGHVLLHRTPEEYPESAKVYEKLKDHLLIPVSNSEMEKVDGLLTCCSVFINKKIDS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAGLGHPSA ------CCCCCCCCH	23.17	-
8	Phosphorylation	MAGLGHPSAFGRATH CCCCCCCCHHCCCCC	30.47	22817900
33	Phosphorylation	CRHALRRSQGEEVDF HHHHHHHCCCCCCCH	35.78	25521595
50	Phosphorylation	AERQHELYVGVLGSK HHHHHHEEEEECCCC	7.68	29472430
56	Phosphorylation	LYVGVLGSKLGLQVV EEEEECCCCCCEEEE	22.13	25521595
106	Ubiquitination	RKEVDMMKEALEKLQ HHHHHHHHHHHHHHC	32.95	22790023
106	Acetylation	RKEVDMMKEALEKLQ HHHHHHHHHHHHHHC	32.95	22826441
144	Acetylation	EFFVGLSKRTNQRGA EEEEECCHHCCCCCC	69.18	7744513
144	Malonylation	EFFVGLSKRTNQRGA EEEEECCHHCCCCCC	69.18	26320211
159	Acetylation	EILADTFKDYAVSTV HHHHHHHHHHCCCCC	52.50	22826441
159	Ubiquitination	EILADTFKDYAVSTV HHHHHHHHHHCCCCC	52.50	22790023
171	Phosphorylation	STVPVADSLHLKSFC CCCCCCCHHCHHHHH	14.14	29899451
199	Malonylation	ESAQKALKIMQQMSD HHHHHHHHHHHHHCC	40.78	26320211
211	Acetylation	MSDHRYDKLTVPDDM HCCCCCCCCCCCCHH	36.80	22826441
222	S-nitrosocysteine	PDDMAANCIYLNIPS CCHHHCCEEEEECCC	1.53	-
222	S-nitrosylation	PDDMAANCIYLNIPS CCHHHCCEEEEECCC	1.53	-
247	Succinylation	EEYPESAKVYEKLKD CCCCCHHHHHHHHHH	55.41	23954790
247	Ubiquitination	EEYPESAKVYEKLKD CCCCCHHHHHHHHHH	55.41	-
247	Acetylation	EEYPESAKVYEKLKD CCCCCHHHHHHHHHH	55.41	22826441
253	Acetylation	AKVYEKLKDHLLIPV HHHHHHHHHCEEEEC	54.92	22826441
261	O-linked_Glycosylation	DHLLIPVSNSEMEKV HCEEEECCCCHHHHH	29.32	55411709
274	S-nitrosylation	KVDGLLTCCSVFINK HHCHHHHHHHHHHCC	1.32	-
274	S-nitrosocysteine	KVDGLLTCCSVFINK HHCHHHHHHHHHHCC	1.32	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DDAH1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DDAH1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DDAH1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of DDAH1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.