DCSTP_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DCSTP_HUMAN
• UniProt AC: Q9H295
• Protein Name: Dendritic cell-specific transmembrane protein
• Gene Name: DCSTAMP
• Organism: Homo sapiens (Human).
• Sequence Length: 470
• Subcellular Localization: Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Endosome. Localizes to the cell surface in osteoclast
• Protein Description: Probable cell surface receptor that plays several roles in cellular fusion, cell differentiation, bone and immune homeostasis. Plays a role in TNFSF11-mediated osteoclastogenesis. Cooperates with OCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Participates in osteoclast bone resorption. Involved in inducing the expression of tartrate-resistant acid phosphatase in osteoclast precursors. Plays a role in haematopoietic stem cell differentiation of bone marrow cells toward the myeloid lineage. Inhibits the development of neutrophilic granulocytes. Plays also a role in the regulation of dendritic cell (DC) antigen presentation activity by controlling phagocytic activity. Involved in the maintenance of immune self-tolerance and avoidance of autoimmune reactions..
• Protein Sequence: MGIWTSGTDIFLSLWEIYVSPRSPGWMDFIQHLGVCCLVALISVGLLSVAACWFLPSIIAAAASWIITCVLLCCSKHARCFILLVFLSCGLREGRNALIAAGTGIVILGHVENIFHNFKGLLDGMTCNLRAKSFSIHFPLLKKYIEAIQWIYGLATPLSVFDDLVSWNQTLAVSLFSPSHVLEAQLNDSKGEVLSVLYQMATTTEVLSSLGQKLLAFAGLSLVLLGTGLFMKRFLGPCGWKYENIYITRQFVQFDERERHQQRPCVLPLNKEERRKYVIIPTFWPTPKERKNLGLFFLPILIHLCIWVLFAAVDYLLYRLIFSVSKQFQSLPGFEVHLKLHGEKQGTQDIIHDSSFNISVFEPNCIPKPKFLLSETWVPLSVILLILVMLGLLSSILMQLKILVSASFYPSVERKRIQYLHAKLLKKRSKQPLGEVKRRLSLYLTKIHFWLPVLKMIRKKQMDMASADKS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
20	Phosphorylation	SLWEIYVSPRSPGWM HHHEECCCCCCCCHH	9.53	24719451
411	Phosphorylation	VSASFYPSVERKRIQ HHCCCCCCHHHHHHH	25.82	26091039
419	Phosphorylation	VERKRIQYLHAKLLK HHHHHHHHHHHHHHH	9.70	-
441	Phosphorylation	GEVKRRLSLYLTKIH HHHHHHHHHHHHHHH	17.10	22210691
445	Phosphorylation	RRLSLYLTKIHFWLP HHHHHHHHHHHHHHH	17.88	24719451
455	Ubiquitination	HFWLPVLKMIRKKQM HHHHHHHHHHHHHHH	32.30	32015554
466	Phosphorylation	KKQMDMASADKS--- HHHHHHHHCCCC---	30.29	22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DCSTP_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DCSTP_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DCSTP_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
OS9_HUMAN	OS9	physical	18952287

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.