| UniProt ID | DCHS_HUMAN | |
|---|---|---|
| UniProt AC | P19113 | |
| Protein Name | Histidine decarboxylase | |
| Gene Name | HDC | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 662 | |
| Subcellular Localization | ||
| Protein Description | Catalyzes the biosynthesis of histamine from histidine.. | |
| Protein Sequence | MMEPEEYRERGREMVDYICQYLSTVRERRVTPDVQPGYLRAQLPESAPEDPDSWDSIFGDIERIIMPGVVHWQSPHMHAYYPALTSWPSLLGDMLADAINCLGFTWASSPACTELEMNVMDWLAKMLGLPEHFLHHHPSSQGGGVLQSTVSESTLIALLAARKNKILEMKTSEPDADESCLNARLVAYASDQAHSSVEKAGLISLVKMKFLPVDDNFSLRGEALQKAIEEDKQRGLVPVFVCATLGTTGVCAFDCLSELGPICAREGLWLHIDAAYAGTAFLCPEFRGFLKGIEYADSFTFNPSKWMMVHFDCTGFWVKDKYKLQQTFSVNPIYLRHANSGVATDFMHWQIPLSRRFRSVKLWFVIRSFGVKNLQAHVRHGTEMAKYFESLVRNDPSFEIPAKRHLGLVVFRLKGPNCLTENVLKEIAKAGRLFLIPATIQDKLIIRFTVTSQFTTRDDILRDWNLIRDAATLILSQHCTSQPSPRVGNLISQIRGARAWACGTSLQSVSGAGDDPVQARKIIKQPQRVGAGPMKRENGLHLETLLDPVDDCFSEEAPDATKHKLSSFLFSYLSVQTKKKTVRSLSCNSVPVSAQKPLPTEASVKNGGSSRVRIFSRFPEDMMMLKKSAFKKLIKFYSVPSFPECSSQCGLQLPCCPLQAMV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 139 | Phosphorylation | HFLHHHPSSQGGGVL HHHHCCCCCCCCCCC | 30.82 | 22210691 | |
| 140 | Phosphorylation | FLHHHPSSQGGGVLQ HHHCCCCCCCCCCCC | 36.98 | 22210691 | |
| 154 | Phosphorylation | QSTVSESTLIALLAA CCCCCHHHHHHHHHH | 20.38 | 22210691 | |
| 204 | Phosphorylation | VEKAGLISLVKMKFL HHHHCHHEEEECEEC | 31.95 | 24719451 | |
| 305 | N6-(pyridoxal phosphate)lysine | SFTFNPSKWMMVHFD EEEECHHCEEEEEEE | 40.12 | - | |
| 305 | Other | SFTFNPSKWMMVHFD EEEECHHCEEEEEEE | 40.12 | - | |
| 327 | Phosphorylation | DKYKLQQTFSVNPIY CCEEEEEEEEECCEE | 12.62 | - | |
| 505 | Phosphorylation | RAWACGTSLQSVSGA CEECCCCCCCCCCCC | 15.08 | 24719451 | |
| 510 | Phosphorylation | GTSLQSVSGAGDDPV CCCCCCCCCCCCCHH | 28.33 | 24719451 | |
| 581 | Phosphorylation | SVQTKKKTVRSLSCN CCCCCCCEEHHHCCC | 29.99 | 22199227 | |
| 584 | Phosphorylation | TKKKTVRSLSCNSVP CCCCEEHHHCCCCCC | 21.94 | 22199227 | |
| 586 | Phosphorylation | KKTVRSLSCNSVPVS CCEEHHHCCCCCCCC | 16.70 | 23401153 | |
| 589 | Phosphorylation | VRSLSCNSVPVSAQK EHHHCCCCCCCCCCC | 31.93 | 29888752 | |
| 593 | Phosphorylation | SCNSVPVSAQKPLPT CCCCCCCCCCCCCCC | 20.93 | 29888752 | |
| 609 | Phosphorylation | ASVKNGGSSRVRIFS CHHHCCCCCCEEEEE | 19.17 | - | |
| 610 | Phosphorylation | SVKNGGSSRVRIFSR HHHCCCCCCEEEEEC | 37.76 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of DCHS_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of DCHS_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of DCHS_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| DTX2_HUMAN | DTX2 | physical | 25416956 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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