DCE1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DCE1_RAT
• UniProt AC: P18088
• Protein Name: Glutamate decarboxylase 1
• Gene Name: Gad1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 593
• Protein Description: Catalyzes the production of GABA..
• Protein Sequence: MASSTPSPATSSNAGADPNTTNLRPTTYDTWCGVAHGCTRKLGLKICGFLQRTNSLEEKSRLVSAFRERQASKNLLSCENSDPGARFRRTETDFSNLFAQDLLPAKNGEEQTVQFLLEVVDILLNYVRKTFDRSTKVLDFHHPHQLLEGMEGFNLELSDHPESLEQILVDCRDTLKYGVRTGHPRFFNQLSTGLDIIGLAGEWLTSTANTNMFTYEIAPVFVLMEQITLKKMREIIGWSNKDGDGIFSPGGAISNMYSIMAARYKYFPEVKTKGMAAVPKLVLFTSEHSHYSIKKAGAALGFGTDNVILIKCNERGKIIPADLEAKILDAKQKGFVPLYVNATAGTTVYGAFDPIQEIADICEKYNLWLHVDAAWGGGLLMSRKHRHKLSGIERANSVTWNPHKMMGVLLQCSAILVKEKGILQGCNQMCAGYLFQPDKQYDVSYDTGDKAIQCGRHVDIFKFWLMWKAKGTVGFENQINKCLELAEYLYAKIKNREEFEMVFNGEPEHTNVCFWYIPQSLRGVPDSPERREKLHRVAPKIKALMMESGTTMVGYQPQGDKANFFRMVISNPAATQSDIDFLIEEIERLGQDL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
53	Phosphorylation	ICGFLQRTNSLEEKS HHHHHHHCCCHHHHH	19.05	27115346
55	Phosphorylation	GFLQRTNSLEEKSRL HHHHHCCCHHHHHHH	36.22	25403869
59	Ubiquitination	RTNSLEEKSRLVSAF HCCCHHHHHHHHHHH	31.34	-
73	Ubiquitination	FRERQASKNLLSCEN HHHHHHHCCCCCCCC	55.41	-
77	Phosphorylation	QASKNLLSCENSDPG HHHCCCCCCCCCCCC	23.66	28432305
81	Phosphorylation	NLLSCENSDPGARFR CCCCCCCCCCCCCCC	23.92	28432305
176	Acetylation	VDCRDTLKYGVRTGH HHHHHHHHHCCCCCC	41.89	22902405
264	Phosphorylation	YSIMAARYKYFPEVK HHHHHHHHHHCCCCC	12.81	-
271	Acetylation	YKYFPEVKTKGMAAV HHHCCCCCCCCCCCC	42.74	22902405
404	N6-(pyridoxal phosphate)lysine	SVTWNPHKMMGVLLQ CCCCCHHHHHHHHHH	31.66	-
404	Other	SVTWNPHKMMGVLLQ CCCCCHHHHHHHHHH	31.66	-
527	Phosphorylation	SLRGVPDSPERREKL HHCCCCCCHHHHHHH	23.69	25403869

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DCE1_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DCE1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DCE1_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of DCE1_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.