DCAF6_MOUSE - dbPTM
DCAF6_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DCAF6_MOUSE
UniProt AC Q9DC22
Protein Name DDB1- and CUL4-associated factor 6
Gene Name Dcaf6
Organism Mus musculus (Mouse).
Sequence Length 876
Subcellular Localization Nucleus.
Protein Description Ligand-dependent coactivator of nuclear receptors. Enhance transcriptional activity of the nuclear receptors NR3C1 and AR. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex (By similarity)..
Protein Sequence MARSGSCPHLLWDVRKRSLGLEDPSRLRSRYLGRREFIQRLKLEATLNVHDGCVNTICWNDTGEYILSGSDDTKLVISNPYSRKVLTTIRSGHRANIFSAKFLPCTDDKQIVSCSGDGVIFYTNIEQDAETNRQCQFTCHYGTTYEIMTVPNDPYTFLSCGEDGTVRWFDTRIKTSCTKEDCKDDILINCRRAATSVAICPPVPYYLAVGCSDSSVRIYDRRMLGTRATGNYAGRGTTGMVARFIPSHLSNKSCRVTSLCYSEDGQEILVSYSSDYIYLFDPKDDTARELKTPSAEERREELRQPPVKRLRLRGDWSDTGPRARPESERERDGEQSPNVSLMQRMSDMLSRWFEEASEVAQSNRGRGRPRPRGGTNQPDVSTLPTVPSSPNLEVCETAMDVDMPAALLQPSTSSTDPVQAQAATAAIESPRSSSLLSCPDSEPRQSVEASGHHAHHQSDNSNERLSPKPGTGEPVLSLHYSTEGTTTSTIKLNFTDEWSSTASSSRGNGSHCKSEGQEECLVPPSSVQPPEGDSETRAPEELSEKGTLPENLTQNQIDTAQLDNFPAEPLDSNSGEKNNPSQDSPCGLPEEGTLSETDRETCEQASTESATRHASTKPELPSQTEAIEQASTESATRHTSANPELPSQTEAIAPLAHEDPSARDSALQDTDDSDDDPVLIPGARYRTGPGDRRSAVARIQEFFRRRKERKEMEELDTLNIRRPLVKMVYKGHRNSRTMIKEANFWGANFVMSGSDCGHIFIWDRHTAEHLMLLEADNHVVNCLQPHPFDPILASSGIDYDIKIWSPLEESRIFNRKLADEVITRNELMLEETRNTITVPASFMLRMLASLNHIRADRLEGDRSEGSGQENENEDEE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4Phosphorylation----MARSGSCPHLL
----CCCCCCCCCHH		26.0625293948
6Phosphorylation--MARSGSCPHLLWD
--CCCCCCCCCHHHH		26.2325293948
18PhosphorylationLWDVRKRSLGLEDPS
HHHHHHHHCCCCCHH		29.8025367039
25PhosphorylationSLGLEDPSRLRSRYL
HCCCCCHHHHHHHHH		57.1625367039
52UbiquitinationATLNVHDGCVNTICW
EEEECCCCCEEEEEE		11.4627667366
232PhosphorylationGTRATGNYAGRGTTG
CCCCCCCCCCCCCHH		16.27-
291UbiquitinationDDTARELKTPSAEER
CCCHHHCCCCCHHHH		54.3522790023
327PhosphorylationGPRARPESERERDGE
CCCCCCHHHHHCCCC		44.6429899451
336PhosphorylationRERDGEQSPNVSLMQ
HHCCCCCCCCHHHHH		17.7225521595
340PhosphorylationGEQSPNVSLMQRMSD
CCCCCCHHHHHHHHH		25.4325619855
429PhosphorylationAATAAIESPRSSSLL
HHHHHHCCCCCCCCC		21.3525338131
432PhosphorylationAAIESPRSSSLLSCP
HHHCCCCCCCCCCCC		27.8825293948
433PhosphorylationAIESPRSSSLLSCPD
HHCCCCCCCCCCCCC		26.7025293948
434PhosphorylationIESPRSSSLLSCPDS
HCCCCCCCCCCCCCC		34.2825293948
437PhosphorylationPRSSSLLSCPDSEPR
CCCCCCCCCCCCCCC		28.9725293948
441PhosphorylationSLLSCPDSEPRQSVE
CCCCCCCCCCCCCCC		34.3430635358
581PhosphorylationSGEKNNPSQDSPCGL
CCCCCCCCCCCCCCC		49.0626160508
584PhosphorylationKNNPSQDSPCGLPEE
CCCCCCCCCCCCCCC		17.9126525534
593PhosphorylationCGLPEEGTLSETDRE
CCCCCCCCCCCHHHH		30.3226160508
595PhosphorylationLPEEGTLSETDRETC
CCCCCCCCCHHHHHH		37.9826160508
597PhosphorylationEEGTLSETDRETCEQ
CCCCCCCHHHHHHHH		36.6625521595
655UbiquitinationQTEAIAPLAHEDPSA
CCCCCHHHCCCCCCC		5.8527667366
665PhosphorylationEDPSARDSALQDTDD
CCCCCCCHHCCCCCC		25.8921082442
670PhosphorylationRDSALQDTDDSDDDP
CCHHCCCCCCCCCCC		28.8425521595
673PhosphorylationALQDTDDSDDDPVLI
HCCCCCCCCCCCCEE		45.8325521595
710UbiquitinationFRRRKERKEMEELDT
HHHHHHHHHHHHHHH		63.6122790023
816UbiquitinationESRIFNRKLADEVIT
HHCHHCHHHHHHHHH		49.4822790023
836UbiquitinationLEETRNTITVPASFM
HHHHCCCCCCCHHHH		4.1127667366
849PhosphorylationFMLRMLASLNHIRAD
HHHHHHHHCCCCCHH		26.2422817900
863PhosphorylationDRLEGDRSEGSGQEN
HHCCCCCCCCCCCCC		51.5625521595
866PhosphorylationEGDRSEGSGQENENE
CCCCCCCCCCCCCCC		33.0025521595
894Ubiquitination-------------------------
-------------------------		27667366
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DCAF6_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DCAF6_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DCAF6_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
GT2D1_HUMANGTF2IRD1physical
26275350
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DCAF6_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-673, AND MASSSPECTROMETRY.

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