dbPTM

DBP4_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DBP4_SCHPO
UniProt AC	Q9UTP9
Protein Name	ATP-dependent RNA helicase dbp4
Gene Name	dbp4
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	735
Subcellular Localization	Nucleus, nucleolus.
Protein Description	ATP-dependent RNA helicase required for ribosome biogenesis. Involved in the release of U14 snoRNA in pre-ribosomal complexes. Required for pre-rRNA cleavage at site A2 (By similarity)..
Protein Sequence	MPKNRTGRSREAREKKRKEEEEEIEELNSQIEALSETVDHFAELPLTQPTKSALKNAHFITLTEIQKQCIPSALKGRDILGAAKTGSGKTLAFIVPLIENLYRKKWTSLDGLGALVISPTRELAIQTFETLVKIGRLHSFSAGLIIGGNNYKEEKERLSRMNILVCTPGRLLQHIDQAVNFDTSGLQMLILDEADRILDMGFRTTLDAIVSSLPVHRQTMLFSATQTKSVKDLARLSLQNPDFISVHENDTSSTPSNLNQFYLTVPLTEKLDILFGFIRTHLKFKTIVFLSSCKQVRFVYETFRRMRPGISLLHLHGKQKQTTRTEVTAKFTSSRHVVLFCTDIVARGLDFPAVDWVIQLDAPEDVDTYIHRVGRTARYNRSGNALLLLLPSEEAFLKRLESKKIAVERINVKDGKKTSIRNQLQNLCFKDNDIKYIGQKAFISYLRSIYLQKDKDVFQLDKLPVEAFADSLGLPGTPKITFGKLKNHSQSQKDYNSSTSLDSSEESEVDVENKQNVRTKYDRIFERKNQDVLAAHRQRLVEVNSDEDDGDFLQVKRVDHDLPEETGERFNANSKRKEKMASSKKAMLKYKKSADKVYFDDEGNAIPFYAMNTEDTFQKAGDPAALIASHLAEERKALEKADITDKETVRQKQLEKKRRRQELERITQQDATPDEYVPEGPIVAFVDDELPETSKKQKKWFEDNDERDHGGIVEVENLNSLEDQEALALKLMGAA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
500	Phosphorylation	KDYNSSTSLDSSEES CCCCCCCCCCCCCCC	31.93	28889911
503	Phosphorylation	NSSTSLDSSEESEVD CCCCCCCCCCCCCCC	44.96	28889911
504	Phosphorylation	SSTSLDSSEESEVDV CCCCCCCCCCCCCCC	45.08	28889911
507	Phosphorylation	SLDSSEESEVDVENK CCCCCCCCCCCCCCH	38.58	21712547
545	Phosphorylation	QRLVEVNSDEDDGDF HHEEECCCCCCCCCC	47.77	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of DBP4_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DBP4_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DBP4_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of DBP4_SCHPO !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DBP4_SCHPO

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of fission yeast."; Wilson-Grady J.T., Villen J., Gygi S.P.; J. Proteome Res. 7:1088-1097(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-500; SER-503; SER-504AND SER-545, AND MASS SPECTROMETRY.	18257517 [Abstract]