dbPTM

DBF4A_XENLA - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DBF4A_XENLA
UniProt AC	Q7ZZH7
Protein Name	Protein DBF4 homolog A
Gene Name	dbf4
Organism	Xenopus laevis (African clawed frog).
Sequence Length	661
Subcellular Localization	Nucleus .
Protein Description	Regulatory subunit for cdc7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Not required during the initiation of DNA replication in egg and during early embryonic development but is required later and throughout development. The complex cdc7-dbf4a phosphorylates mcm2 subunit..
Protein Sequence	MKSTVAAVKNPTGKVQADVCKPFTGKLFYLDLTSKLISEKLEKDIKELGGAIEGFLSKEISYLITSKKEAKCVKTLKYVCSIPSPEAAPNTGESSTSPGNRRLCQEGNSSKKNEKSLVSRGKSLVKRAIKEQEILPKNSILSNALNWGVKILHVEEAKHYIEKKKTALQQVRKSQPVVKVESKPQTRRKVKPQKLKSPYIKVEDCSCQYRPLYLVLPQFRSFQNPVSNYSVEVDKKADPGQKLPETKQSVNKTGHGQDGANNPNIKLKEQKKHGYCECCLKKYDDLESHILSPQHKNFSESAYYQVVDDLISTFDFDFVDWSKYKNGRKGVGILMLAEKSKTEGQERNEANLFVSKTHNFSERVTATTPLQENTLKDQHASPCSLPCTPACNADQMFSLPSPAGSARLCNKKYKMDSNFGQLVATPLPSFNLKDSLTGSFGGREMFVAKLNETMEPATEGPKIKWDVCNIPSNISQCIPQKVDPIAQHVNQFPNGNTHCSEMTACQAALIYENVDSAADANIKLPKTVNDLHNKEGHRATDKIYPTVQSHEYLPDYSPSGNLHRKVKTSAHRNKNKDELFCRLSHKVSVPQQEDDSKFPSETLLALFESSEDKTEFFGFAGSPAYESCSMDDGDTPDQTHKKMLLSLFPHTTTSGSSFLGF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
Oops, there are no PTM records of DBF4A_XENLA !!

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of DBF4A_XENLA !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DBF4A_XENLA !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DBF4A_XENLA !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
CA1AB_XENLA	chaf1a	physical	16826239
MCM2_XENLA	mcm2	physical	16507577

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DBF4A_XENLA

Related Literatures of Post-Translational Modification