dbPTM

DAAF4_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DAAF4_MOUSE
UniProt AC	Q8R368
Protein Name	Dynein assembly factor 4, axonemal {ECO:0000250\|UniProtKB:Q8WXU2}
Gene Name	Dnaaf4 {ECO:0000250\|UniProtKB:Q8WXU2}
Organism	Mus musculus (Mouse).
Sequence Length	420
Subcellular Localization	Nucleus. Cytoplasm .
Protein Description	Involved in neuronal migration during development of the cerebral neocortex. May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity (By similarity). Axonemal dynein assembly factor required for ciliary motility..
Protein Sequence	MPVRVSEFSWQQTPATIFLSLPLRGVCVRDADVFCGESYLKVNFPPFLFELFLYAPIDDGKSKAKIGNDTILFTLYKKEPVLWDSLSVPGVDKEMMQRIREKSILQAQEKAKEATEAKAVAKREDQRYALGEMMKIEEEERKKIEDMKENERKKATSELEAWKECQKKADGQKRVQRKEKPLEGKQAEETKALKPRGLPRKAPPTRLPTRGRNWENIFPEKLKEDRVPAPRSAGSIQISFTPRVFPTALRESQVAEEEEWLHKQAEARRAMSTDLPEFFDLKEEERNPDWLKDKGNKLFATENYLAAVDAYNLAIRLNCKIPLLYLNRAACHLKLKNLHKAIEDSSKALELLTPPVADNANARMKAHVRRGTAFCQLELYVEGLQDYEAALKIDPANTVVQNDAEKIRNIIQGTALKSRD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	Reference
168	Acetylation	AWKECQKKADGQKRV HHHHHHHHHHHHHHC	23576753
173	Acetylation	QKKADGQKRVQRKEK HHHHHHHHHCHHHCC	23576753
232	Phosphorylation	DRVPAPRSAGSIQIS CCCCCCCCCCCEEEE	23140645
235	Phosphorylation	PAPRSAGSIQISFTP CCCCCCCCEEEEECC	23140645
239	Phosphorylation	SAGSIQISFTPRVFP CCCCEEEEECCCCCC	23140645
241	Phosphorylation	GSIQISFTPRVFPTA CCEEEEECCCCCCHH	23140645

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of DAAF4_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DAAF4_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DAAF4_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of DAAF4_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DAAF4_MOUSE

Related Literatures of Post-Translational Modification