DAAF3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DAAF3_HUMAN
• UniProt AC: Q8N9W5
• Protein Name: Dynein assembly factor 3, axonemal
• Gene Name: DNAAF3
• Organism: Homo sapiens (Human).
• Sequence Length: 541
• Subcellular Localization: Cytoplasm.
• Protein Description: Required for the assembly of axonemal inner and outer dynein arms. Involved in preassembly of dyneins into complexes before their transport into cilia..
• Protein Sequence: MTTPAGSGSGFGSVSWWGLSPALDLQAESPPVDPDSQADTVHSNPELDVLLLGSVDGRHLLRTLSRAKFWPRRRFNFFVLENNLEAVARHMLIFSLALEEPEKMGLQERSETFLEVWGNALLRPPVAAFVRAQADLLAHLVPEPDRLEEQLPWLSLRALKFRERDALEAVFRFWAGGEKGPQAFPMSRLWDSRLRHYLGSRYDARRGVSDWDLRMKLHDRGAQVIHPQEFRRWRDTGVAFELRDSSAYHVPNRTLASGRLLSYRGERVAARGYWGDIATGPFVAFGIEADDESLLRTSNGQPVKTAGEITQHNVTELLRDVAAWGRARATGGDLEEQQHAEGSPEPGTPAAPTPESFTVHFLPLDSAQTLHHKSCYNGRFQLLYVACGMVHLLIPELGACVAPGGNLIVELARYLVDVRQEQLQGFNTRVRELAQAAGFAPQTGARPSETFARFCKSQESALGNTVPAVEPGTPPLDILAQPLEASNPALEGLTQPLQGGTPHCEPCQLPSESPGSLSEVLAQPQGALAPPNCESDSKTGV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7 (in isoform 6)	Phosphorylation	-	31.71	23684312
7 (in isoform 3)	Phosphorylation	-	31.71	23684312
8 (in isoform 6)	Phosphorylation	-	30.76	23684312
8 (in isoform 3)	Phosphorylation	-	30.76	23684312
125	Ubiquitination	GNALLRPPVAAFVRA HHHHHCCCHHHHHHH	23.19	-
179	Ubiquitination	RFWAGGEKGPQAFPM HHHHCCCCCCCCCCH	78.24	-
202	Phosphorylation	RHYLGSRYDARRGVS HHHHCCCCCCCCCCC	18.69	-
206	Methylation	GSRYDARRGVSDWDL CCCCCCCCCCCHHHH	52.14	-
236	Phosphorylation	EFRRWRDTGVAFELR HHHHHHCCEEEEEEE	25.61	24719451
245	Phosphorylation	VAFELRDSSAYHVPN EEEEEECCCCCCCCC	15.50	-
247 (in isoform 3)	Ubiquitination	-	11.47	-
250	Ubiquitination	RDSSAYHVPNRTLAS ECCCCCCCCCCEECC	2.68	-
250	Ubiquitination	RDSSAYHVPNRTLAS ECCCCCCCCCCEECC	2.68	22817900
254	Phosphorylation	AYHVPNRTLASGRLL CCCCCCCEECCCCEE	33.06	22210691
257	Phosphorylation	VPNRTLASGRLLSYR CCCCEECCCCEEEEC	27.79	24719451
262	Phosphorylation	LASGRLLSYRGERVA ECCCCEEEECCCEEE	19.85	22210691
263	Phosphorylation	ASGRLLSYRGERVAA CCCCEEEECCCEEEC	23.70	22210691
283	Phosphorylation	DIATGPFVAFGIEAD CCCCCCEEEEEEEEC	4.93	24719451
304	Phosphorylation	TSNGQPVKTAGEITQ CCCCCCCCCCCHHHH	39.06	24719451
304	Ubiquitination	TSNGQPVKTAGEITQ CCCCCCCCCCCHHHH	39.06	22817900
304 (in isoform 1)	Ubiquitination	-	39.06	21906983
315	Phosphorylation	EITQHNVTELLRDVA HHHHCCHHHHHHHHH	26.66	21964256
351	Ubiquitination	PEPGTPAAPTPESFT CCCCCCCCCCCCCEE	15.09	22817900
372	Ubiquitination	DSAQTLHHKSCYNGR CCCCCCCCCCHHCCH	27.17	22817900
372 (in isoform 3)	Ubiquitination	-	27.17	21906983
428	Phosphorylation	EQLQGFNTRVRELAQ HHHCCCHHHHHHHHH	28.42	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DAAF3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DAAF3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DAAF3_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of DAAF3_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 606763: Ciliary dyskinesia, primary, 2 (CILD2)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.