D6KL3_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: D6KL3_ARATH
• UniProt AC: Q05999
• Protein Name: Serine/threonine-protein kinase D6PKL3
• Gene Name: D6PKL3
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 578
• Subcellular Localization: Cell membrane; Peripheral membrane protein. Colocalizes with PIN1 to the basal (lower) membrane of root cells..
• Protein Description: Protein kinase that regulates the auxin transport activity of PIN auxin efflux facilitators by direct phosphorylation. D6PK-mediated PIN phosphorylation promotes auxin transport in the hypocotyl and this is a prerequisite for PHOT1-dependent hypocotyl bending..
• Protein Sequence: MDSSSSVVYVGSSSKSRNFQSKSKGSITSFSIDSRGTKKSMKTLLIPEPEPTSPEVIESSVSSVSAESETPISIIRKKKQSEPRFYSSPTNTFYTEAKQSFTNTEFSECASISTIGIGGIDLEKNGVMIYRGSIGSDVSDESSSSGLSNAAYKPHRDNNDKRWVAIQEVRSRVGSSLEAKDFKLIKKLGGGDIGNVYLAELIGTGVSFAVKVMEKAAIAARKKLVRAQTEKEILQSLDHPFLPTLYSHFETEMNSCLVMEFCPGGDLHSLRQKQRGKYFPEQAARFYVAEVLLAMEYLHMLGIIYRDLKPENVLVREDGHIMLSDFDLSLRCAVSPTLVRFAAITLESKSSSYCIQPTCVDQSSCIVQPDCIQPVCFTPRFLSKGKHRKKSNDMSRQIRPLPELIAEPTSARSMSFVGTHEYLAPEIIKGEGHGSAVDWWTFGIFLYELLFGITPFRGGDNRATLFNVVGQPLRFPEHPNVSFAARDLIRGLLVKEPQHRLAYRRGATEIKQHPFFQSVNWALIRCTSPPQIPQPVKPMDQAHSVRHGFSQGHGHVGYDKPPTVDVKPSGNYLEIDFF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
86	Phosphorylation	KQSEPRFYSSPTNTF CCCCCCCCCCCCCCC		27643528
87	Phosphorylation	QSEPRFYSSPTNTFY CCCCCCCCCCCCCCC		27643528
88	Phosphorylation	SEPRFYSSPTNTFYT CCCCCCCCCCCCCCH		27643528
90	Phosphorylation	PRFYSSPTNTFYTEA CCCCCCCCCCCCHHH		27643528
92	Phosphorylation	FYSSPTNTFYTEAKQ CCCCCCCCCCHHHHH		27643528
413	Phosphorylation	AEPTSARSMSFVGTH CCCCCCCCCCCCCCC		17317660
415	Phosphorylation	PTSARSMSFVGTHEY CCCCCCCCCCCCCCC		30291188
419	Phosphorylation	RSMSFVGTHEYLAPE CCCCCCCCCCCCCCH		23776212
422	Phosphorylation	SFVGTHEYLAPEIIK CCCCCCCCCCCHHHC		23776212

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of D6KL3_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of D6KL3_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of D6KL3_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HDG1_ARATH	HDG1	physical	21798944

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.