CYSC1_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CYSC1_ARATH
• UniProt AC: Q9S757
• Protein Name: Bifunctional L-3-cyanoalanine synthase/cysteine synthase C1, mitochondrial
• Gene Name: CYSC1
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 368
• Subcellular Localization: Mitochondrion .
• Protein Description: Acts as a major beta-cyanoalanine synthase. The cyanoalanine synthesis reaction is more efficient than the cysteine synthase activity. Probably unable to interact with SAT and to form the decameric Cys synthase complex (CSC) and is therefore not an enzymatically true OASTL protein. Probably involved in the detoxification of cyanide that arises from ethylene biosynthesis. Maintains a low level of cyanide for proper root hair development..
• Protein Sequence: MASVSRRLLRRETIPCFSHTVRKLFSTVGSPSFAQRLRDLPKDFPSTNAKRDASLLIGKTPLVFLNKVTEGCEAYVAAKQEHFQPTCSIKDRPAIAMIADAEKKKLIIPGKTTLIEPTSGNMGISLAFMAAMKGYRIIMTMPSYTSLERRVTMRSFGAELVLTDPAKGMGGTVKKAYDLLDSTPDAFMCQQFANPANTQIHFDTTGPEIWEDTLGNVDIFVMGIGSGGTVSGVGRYLKSKNPNVKIYGVEPAESNILNGGKPGPHAITGNGVGFKPEILDMDVMESVLEVSSEDAIKMARELALKEGLMVGISSGANTVAAIRLAKMPENKGKLIVTIHASFGERYLSSVLFDELRKEAEEMKPVSVD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
30	Phosphorylation	KLFSTVGSPSFAQRL HHHHCCCCHHHHHHH		29654922
42	Acetylation	QRLRDLPKDFPSTNA HHHHCCCCCCCCCCC		24727099
67	Acetylation	TPLVFLNKVTEGCEA CCEEEEEHHHCCHHH		24727099
90	N6-(pyridoxal phosphate)lysine	FQPTCSIKDRPAIAM CCCCCCCCCCCEEEE		-
90	Other	FQPTCSIKDRPAIAM CCCCCCCCCCCEEEE		-
97	Sulfoxidation	KDRPAIAMIADAEKK CCCCEEEEEEEHHCC		25693801
103	Acetylation	AMIADAEKKKLIIPG EEEEEHHCCEEECCC		24727099
169	Sulfoxidation	LTDPAKGMGGTVKKA ECCCCCCCCCHHHHH		25693801
298	Sulfoxidation	SSEDAIKMARELALK CHHHHHHHHHHHHHH		25693801
341	Phosphorylation	LIVTIHASFGERYLS EEEEEEEHHHHHHHH		19376835
362	Sulfoxidation	LRKEAEEMKPVSVD- HHHHHHHHCCCCCC-		23289948

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CYSC1_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CYSC1_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CYSC1_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of CYSC1_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.