CYS1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CYS1_HUMAN
• UniProt AC: Q717R9
• Protein Name: Cystin-1
• Gene Name: CYS1
• Organism: Homo sapiens (Human).
• Sequence Length: 158
• Subcellular Localization: Cell projection, cilium membrane ; Lipid-anchor . Cytoplasm, cytoskeleton, cilium axoneme . Expression is enriched in the ciliary axoneme. Localization to cilium is mediated via interaction with UNC119 and UNC119B, which bind to the myristoyl moiety
• Protein Sequence: MGSGSSRSSRTLRRRRSPESLPAGPGAAALEGGTRRRVPVAAAEVPGAAAEEAPGRDPSPVAPPDGRDETLRLLDELLAESAAWGPPEPAPRRPARLRPTAVAGSAVCAEQSTEGHPGSGNVSEAPGSGRKKPERPAAISYDHSEEGLMASIEREYCR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	N-myristoyl glycine	------MGSGSSRSS ------CCCCCCHHH	40.49	-
2	Myristoylation	------MGSGSSRSS ------CCCCCCHHH	40.49	22085962
17	Phosphorylation	RTLRRRRSPESLPAG HHHHHHCCCCCCCCC	31.07	26657352
20	Phosphorylation	RRRRSPESLPAGPGA HHHCCCCCCCCCCCC	42.93	30108239
34	Phosphorylation	AAALEGGTRRRVPVA CCCCCCCCCCCCCEE	31.68	28857561
59	Phosphorylation	EAPGRDPSPVAPPDG CCCCCCCCCCCCCCC	35.97	26657352
112	Phosphorylation	SAVCAEQSTEGHPGS CEEEECCCCCCCCCC	21.67	23312004
113	Phosphorylation	AVCAEQSTEGHPGSG EEEECCCCCCCCCCC	45.76	23312004
119	Phosphorylation	STEGHPGSGNVSEAP CCCCCCCCCCCCCCC	31.48	22468782
123	Phosphorylation	HPGSGNVSEAPGSGR CCCCCCCCCCCCCCC	31.85	22468782
128	Phosphorylation	NVSEAPGSGRKKPER CCCCCCCCCCCCCCC	34.07	28857561

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CYS1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CYS1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CYS1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of CYS1_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Myristoylation

"An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to theprimary cilium.";
Wright K.J., Baye L.M., Olivier-Mason A., Mukhopadhyay S., Sang L.,Kwong M., Wang W., Pretorius P.R., Sheffield V.C., Sengupta P.,Slusarski D.C., Jackson P.K.;
Genes Dev. 25:2347-2360(2011).
Cited for: MYRISTOYLATION AT GLY-2, INTERACTION WITH UNC119 AND UNC119B, ANDSUBCELLULAR LOCATION.
PubMed: 22085962