CYC_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CYC_RAT
• UniProt AC: P62898
• Protein Name: Cytochrome c, somatic
• Gene Name: Cycs
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 105
• Subcellular Localization: Mitochondrion intermembrane space. Loosely associated with the inner membrane.
• Protein Description: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.; Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases (By similarity)..
• Protein Sequence: MGDVEKGKKIFVQKCAQCHTVEKGGKHKTGPNLHGLFGRKTGQAAGFSYTDANKNKGITWGEDTLMEYLENPKKYIPGTKMIFAGIKKKGERADLIAYLKKATNE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MGDVEKGKK ------CCCHHHCCE	47.90	191069
6	Acetylation	--MGDVEKGKKIFVQ --CCCHHHCCEEEEE	75.72	22902405
8	Acetylation	MGDVEKGKKIFVQKC CCCHHHCCEEEEEEC	54.48	22902405
9	Acetylation	GDVEKGKKIFVQKCA CCHHHCCEEEEEECC	50.47	22902405
28	Acetylation	VEKGGKHKTGPNLHG ECCCCCCCCCCCCCH	59.67	22902405
29	Phosphorylation	EKGGKHKTGPNLHGL CCCCCCCCCCCCCHH	58.55	23991683
40	Succinylation	LHGLFGRKTGQAAGF CCHHCCCCCCCCCCC	58.34	26843850
41	Phosphorylation	HGLFGRKTGQAAGFS CHHCCCCCCCCCCCE	32.92	28689409
48	Phosphorylation	TGQAAGFSYTDANKN CCCCCCCEEECCCCC	26.63	29779826
49	Phosphorylation	GQAAGFSYTDANKNK CCCCCCEEECCCCCC	13.33	20586425
50	Phosphorylation	QAAGFSYTDANKNKG CCCCCEEECCCCCCC	27.69	23991683
56	Succinylation	YTDANKNKGITWGED EECCCCCCCCCCCHH	53.98	-
56	Acetylation	YTDANKNKGITWGED EECCCCCCCCCCCHH	53.98	22902405
56	Succinylation	YTDANKNKGITWGED EECCCCCCCCCCCHH	53.98	-
59	Phosphorylation	ANKNKGITWGEDTLM CCCCCCCCCCHHHHH	35.77	23991683
64	Phosphorylation	GITWGEDTLMEYLEN CCCCCHHHHHHHHHC	24.57	23991683
68	Phosphorylation	GEDTLMEYLENPKKY CHHHHHHHHHCHHHC	12.83	23991683
73	Succinylation	MEYLENPKKYIPGTK HHHHHCHHHCCCCCC	70.55	26843850
73	Succinylation	MEYLENPKKYIPGTK HHHHHCHHHCCCCCC	70.55	-
73	Acetylation	MEYLENPKKYIPGTK HHHHHCHHHCCCCCC	70.55	23923745
74	Acetylation	EYLENPKKYIPGTKM HHHHCHHHCCCCCCE	50.06	23923753
80	Acetylation	KKYIPGTKMIFAGIK HHCCCCCCEEEEEEC	35.59	23923765
88	Acetylation	MIFAGIKKKGERADL EEEEEECCCCCHHHH	65.18	22902405
89	Acetylation	IFAGIKKKGERADLI EEEEECCCCCHHHHH	62.09	22902405
98	Phosphorylation	ERADLIAYLKKATNE CHHHHHHHHHHHHCC	16.44	23991683
100	Acetylation	ADLIAYLKKATNE-- HHHHHHHHHHHCC--	27.90	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CYC_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CYC_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CYC_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of CYC_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Primary structure of mouse, rat, and guinea pig cytochrome c.";
Carlson S.S., Mross G.A., Wilson A.C., Mead R.T., Wolin L.D.,Bowers S.F., Foley N.T., Muijsers A.O., Margoliash E.;
Biochemistry 16:1437-1442(1977).
Cited for: PROTEIN SEQUENCE OF 2-105, AND ACETYLATION AT GLY-2.
PubMed: 191069