CYB5_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CYB5_MOUSE
• UniProt AC: P56395
• Protein Name: Cytochrome b5
• Gene Name: Cyb5a
• Organism: Mus musculus (Mouse).
• Sequence Length: 134
• Subcellular Localization: Endoplasmic reticulum membrane; Single-pass membrane protein; Cytoplasmic side. Microsome membrane; Single-pass membrane protein; Cytoplasmic side.
• Protein Description: Cytochrome b5 is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases. It is also involved in several steps of the sterol biosynthesis pathway, particularly in the C-5 double bond introduction during the C-5 desaturation..
• Protein Sequence: MAGQSDKDVKYYTLEEIQKHKDSKSTWVILHHKVYDLTKFLEEHPGGEEVLREQAGGDATENFEDVGHSTDARELSKTYIIGELHPDDRSKIAKPSDTLITTVESNSSWWTNWVIPAISALAVALMYRLYMAED

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAGQSDKDV ------CCCCCHHHC	25.40	-
5	Phosphorylation	---MAGQSDKDVKYY ---CCCCCHHHCCEE	45.79	30352176
7	Acetylation	-MAGQSDKDVKYYTL -CCCCCHHHCCEEEH	70.44	23576753
7	Ubiquitination	-MAGQSDKDVKYYTL -CCCCCHHHCCEEEH	70.44	-
7	Malonylation	-MAGQSDKDVKYYTL -CCCCCHHHCCEEEH	70.44	26073543
10	Malonylation	GQSDKDVKYYTLEEI CCCHHHCCEEEHHHH	42.55	26320211
10	Ubiquitination	GQSDKDVKYYTLEEI CCCHHHCCEEEHHHH	42.55	-
10	Acetylation	GQSDKDVKYYTLEEI CCCHHHCCEEEHHHH	42.55	23576753
11	Phosphorylation	QSDKDVKYYTLEEIQ CCHHHCCEEEHHHHH	11.09	22817900
13	Phosphorylation	DKDVKYYTLEEIQKH HHHCCEEEHHHHHHC	25.30	29176673
19	Acetylation	YTLEEIQKHKDSKST EEHHHHHHCCCCCCE	59.28	23806337
19	Ubiquitination	YTLEEIQKHKDSKST EEHHHHHHCCCCCCE	59.28	-
19	Malonylation	YTLEEIQKHKDSKST EEHHHHHHCCCCCCE	59.28	26320211
24	Ubiquitination	IQKHKDSKSTWVILH HHHCCCCCCEEEEEE	63.14	-
24	Malonylation	IQKHKDSKSTWVILH HHHCCCCCCEEEEEE	63.14	26073543
33	Acetylation	TWVILHHKVYDLTKF EEEEEEHHHHHHHHH	31.57	21728379
33	Malonylation	TWVILHHKVYDLTKF EEEEEEHHHHHHHHH	31.57	26073543
39	Malonylation	HKVYDLTKFLEEHPG HHHHHHHHHHHHCCC	56.07	26073543
39	Ubiquitination	HKVYDLTKFLEEHPG HHHHHHHHHHHHCCC	56.07	-
39	Acetylation	HKVYDLTKFLEEHPG HHHHHHHHHHHHCCC	56.07	23864654
60	Phosphorylation	EQAGGDATENFEDVG HHHCCCCCCCHHHCC	35.88	26525534
69	Phosphorylation	NFEDVGHSTDARELS CHHHCCCCCCHHHHH	23.27	23684622
70	Phosphorylation	FEDVGHSTDARELSK HHHCCCCCCHHHHHC	28.18	26525534
77	Malonylation	TDARELSKTYIIGEL CCHHHHHCEEEEEEE	58.95	26320211
77	Ubiquitination	TDARELSKTYIIGEL CCHHHHHCEEEEEEE	58.95	-
77	Acetylation	TDARELSKTYIIGEL CCHHHHHCEEEEEEE	58.95	23864654
90	Phosphorylation	ELHPDDRSKIAKPSD EECCCCHHHCCCCCC	35.09	29514104
96	Phosphorylation	RSKIAKPSDTLITTV HHHCCCCCCCEEEEE	42.39	29895711
111	Phosphorylation	ESNSSWWTNWVIPAI CCCCCHHHCCHHHHH	16.97	29895711
127	Phosphorylation	ALAVALMYRLYMAED HHHHHHHHHHHHCCC	9.79	29895711

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CYB5_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CYB5_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CYB5_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of CYB5_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Substrate and functional diversity of lysine acetylation revealed bya proteomics survey.";
Kim S.C., Sprung R., Chen Y., Xu Y., Ball H., Pei J., Cheng T.,Kho Y., Xiao H., Xiao L., Grishin N.V., White M., Yang X.-J., Zhao Y.;
Mol. Cell 23:607-618(2006).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-19, AND MASS SPECTROMETRY.
PubMed: 16916647