CXG2_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CXG2_RAT
• UniProt AC: Q80XF7
• Protein Name: Gap junction gamma-2 protein
• Gene Name: Gjc2
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 440
• Subcellular Localization: Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
• Protein Description: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a role in myelination in central and peripheral nervous systems (By similarity)..
• Protein Sequence: MTNMSWSFLTRLLEEIHNHSTFVGKVWLTVLVVFRIVLTAVGGESIYSDEQSKFTCNTRQPGCDNVCYDAFAPLSHVRFWVFQIVVISTPSVMYLGYAVHRLARASEQERRRALRRRPGPRRLPRAQLPPPPPGWPDTTDLGEAEPILALEEDEDEEPGAPEGPGEDTEEERTEDVAAKGGGGDGKTVVTPGPAGQHDGRRRIQREGLMRVYVAQLVVRAAFEVAFLVGQYLLYGFEVPPFFACSRQPCPHVVDCFVSRPTEKTVFLLVMYVVSCLCLLLNLCEMAHLGLGSAQDAVRGRRGASAAGPGPAPRPPPCAFPAAAAGLACPPDYSLVVRAAERARAHDQNLANLALQALRDGAAVAAVSADRDSPPCSGLNATSRGPPRAGGPASGTGSATSGGTVGEQGRSGAQEQLATKPRVGSEKGSTGSRDGKATVWI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
186	Ubiquitination	KGGGGDGKTVVTPGP CCCCCCCCEEECCCC	42.77	-
367	Phosphorylation	GAAVAAVSADRDSPP CCEEEEEECCCCCCC	21.52	28551015
372	Phosphorylation	AVSADRDSPPCSGLN EEECCCCCCCCCCCC	31.47	28551015
376	Phosphorylation	DRDSPPCSGLNATSR CCCCCCCCCCCCCCC	52.68	28551015
381	Phosphorylation	PCSGLNATSRGPPRA CCCCCCCCCCCCCCC	20.20	28551015
382	Phosphorylation	CSGLNATSRGPPRAG CCCCCCCCCCCCCCC	32.59	28551015
419	Ubiquitination	AQEQLATKPRVGSEK HHHHHCCCCCCCCCC	25.81	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CXG2_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CXG2_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CXG2_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of CXG2_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.