CXB1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CXB1_RAT
• UniProt AC: P08033
• Protein Name: Gap junction beta-1 protein
• Gene Name: Gjb1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 283
• Subcellular Localization: Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
• Protein Description: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell..
• Protein Sequence: MNWTGLYTLLSGVNRHSTAIGRVWLSVIFIFRIMVLVVAAESVWGDEKSSFICNTLQPGCNSVCYDHFFPISHVRLWSLQLILVSTPALLVAMHVAHQQHIEKKMLRLEGHGDPLHLEEVKRHKVHISGTLWWTYVISVVFRLLFEAVFMYVFYLLYPGYAMVRLVKCEAFPCPNTVDCFVSRPTEKTVFTVFMLAASGICIILNVAEVVYLIIRACARRAQRRSNPPSRKGSGFGHRLSPEYKQNEINKLLSEQDGSLKDILRRSPGTGAGLAEKSDRCSAC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
121	Ubiquitination	PLHLEEVKRHKVHIS CCCHHHHHHCCCEEE	52.65	-
225	Phosphorylation	ARRAQRRSNPPSRKG HHHHHHHCCCCCCCC	56.74	25575281
229	Phosphorylation	QRRSNPPSRKGSGFG HHHCCCCCCCCCCCC	48.13	25575281
233	Phosphorylation	NPPSRKGSGFGHRLS CCCCCCCCCCCCCCC	33.70	29779826
240	Phosphorylation	SGFGHRLSPEYKQNE CCCCCCCCHHHHHHH	18.68	29779826
243	Phosphorylation	GHRLSPEYKQNEINK CCCCCHHHHHHHHHH	22.66	22673903
244	Ubiquitination	HRLSPEYKQNEINKL CCCCHHHHHHHHHHH	45.01	-
250	Ubiquitination	YKQNEINKLLSEQDG HHHHHHHHHHHCCCC	57.37	-
253	Phosphorylation	NEINKLLSEQDGSLK HHHHHHHHCCCCCHH	43.58	23984901
258	Phosphorylation	LLSEQDGSLKDILRR HHHCCCCCHHHHHHH	40.30	29779826
260	Ubiquitination	SEQDGSLKDILRRSP HCCCCCHHHHHHHCC	44.41	-
266	Phosphorylation	LKDILRRSPGTGAGL HHHHHHHCCCCCCCH	22.65	29779826
269	Phosphorylation	ILRRSPGTGAGLAEK HHHHCCCCCCCHHHH	27.52	28689409
277	Phosphorylation	GAGLAEKSDRCSAC- CCCHHHHCCCCCCC-	23.07	25575281
281	Phosphorylation	AEKSDRCSAC----- HHHCCCCCCC-----	33.30	25575281

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
233	S	Phosphorylation	Kinase	PRKACA	P00517	GPS
233	S	Phosphorylation	Kinase	PRKCA	P04409	GPS
233	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
233	S	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
233	S	Phosphorylation	Kinase	PKA_GROUP	-	PhosphoELM
233	S	Phosphorylation	Kinase	PKC_GROUP	-	PhosphoELM

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CXB1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CXB1_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of CXB1_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.