dbPTM

CWC15_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CWC15_MOUSE
UniProt AC	Q9JHS9
Protein Name	Spliceosome-associated protein CWC15 homolog
Gene Name	Cwc15
Organism	Mus musculus (Mouse).
Sequence Length	229
Subcellular Localization	Nucleus .
Protein Description	Involved in pre-mRNA splicing as component of the spliceosome. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing..
Protein Sequence	MTTAARPTFEPARGGRGKGEGDLSQLSKQYSSRDLPSHTKIKYRQTTQDAPEEVRNRDFRRELEERERAAARDKNRDRPTREHTTSSSVSKKPRLDQIPAANLDADDPLTDEEDEDFEEESDDDDTAALLAELEKIKKERAEEQARKEQEQKAEEERIRMENILSGNPLLNLTGPSQPQANFKVKRRWDDDVVFKNCAKGIDDQKKDKRFVNDTLRSEFHKKFMEKYIK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MTTAARPTF ------CCCCCCCCC	25.74	-
13	Methylation	RPTFEPARGGRGKGE CCCCCCCCCCCCCCC	59.83	58857947
18	Acetylation	PARGGRGKGEGDLSQ CCCCCCCCCCCCHHH	53.05	23806337
24	Phosphorylation	GKGEGDLSQLSKQYS CCCCCCHHHHHHHHH	33.54	22817900
30	Phosphorylation	LSQLSKQYSSRDLPS HHHHHHHHHCCCCCC	16.61	29899451
31	Phosphorylation	SQLSKQYSSRDLPSH HHHHHHHHCCCCCCC	19.19	29514104
32	Phosphorylation	QLSKQYSSRDLPSHT HHHHHHHCCCCCCCC	25.53	29514104
43	Phosphorylation	PSHTKIKYRQTTQDA CCCCCEEEEECCCCC	16.07	29899451
46	Phosphorylation	TKIKYRQTTQDAPEE CCEEEEECCCCCCHH	19.89	-
47	Phosphorylation	KIKYRQTTQDAPEEV CEEEEECCCCCCHHH	19.00	26643407
80	Phosphorylation	DKNRDRPTREHTTSS HCCCCCCCCCCCCCC	49.97	29550500
84	Phosphorylation	DRPTREHTTSSSVSK CCCCCCCCCCCCCCC	24.50	29550500
85	Phosphorylation	RPTREHTTSSSVSKK CCCCCCCCCCCCCCC	28.63	29550500
86	Phosphorylation	PTREHTTSSSVSKKP CCCCCCCCCCCCCCC	23.05	29550500
87	Phosphorylation	TREHTTSSSVSKKPR CCCCCCCCCCCCCCC	32.44	29550500
88	Phosphorylation	REHTTSSSVSKKPRL CCCCCCCCCCCCCCH	30.12	29550500
90	Phosphorylation	HTTSSSVSKKPRLDQ CCCCCCCCCCCCHHH	36.59	29550500
110	Phosphorylation	LDADDPLTDEEDEDF CCCCCCCCCCCCCCC	46.91	22802335
121	Phosphorylation	DEDFEEESDDDDTAA CCCCCHHCCCHHHHH	50.01	22942356
126	Phosphorylation	EESDDDDTAALLAEL HHCCCHHHHHHHHHH	22.33	26239621

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CWC15_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CWC15_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CWC15_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of CWC15_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CWC15_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-24, AND MASSSPECTROMETRY.	19367708 [Abstract]