| UniProt ID | CTNS_HUMAN | |
|---|---|---|
| UniProt AC | O60931 | |
| Protein Name | Cystinosin | |
| Gene Name | CTNS | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 367 | |
| Subcellular Localization |
Isoform 1: Lysosome membrane Multi-pass membrane protein . Melanosome . Isoform 2: Lysosome membrane Multi-pass membrane protein. Cell membrane Multi-pass membrane protein. |
|
| Protein Description | Cystine/H(+) symporter thought to transport cystine out of lysosomes. Plays an important role in melanin synthesis, possibly by preventing melanosome acidification and subsequent degradation of tyrosinase TYR.. | |
| Protein Sequence | MIRNWLTIFILFPLKLVEKCESSVSLTVPPVVKLENGSSTNVSLTLRPPLNATLVITFEITFRSKNITILELPDEVVVPPGVTNSSFQVTSQNVGQLTVYLHGNHSNQTGPRIRFLVIRSSAISIINQVIGWIYFVAWSISFYPQVIMNWRRKSVIGLSFDFVALNLTGFVAYSVFNIGLLWVPYIKEQFLLKYPNGVNPVNSNDVFFSLHAVVLTLIIIVQCCLYERGGQRVSWPAIGFLVLAWLFAFVTMIVAAVGVTTWLQFLFCFSYIKLAVTLVKYFPQAYMNFYYKSTEGWSIGNVLLDFTGGSFSLLQMFLQSYNNDQWTLIFGDPTKFGLGVFSIVFDVVFFIQHFCLYRKRPGYDQLN | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 36 | N-linked_Glycosylation | PPVVKLENGSSTNVS CCEEECCCCCCCEEE | 67.11 | 28082515 | |
| 41 | N-linked_Glycosylation | LENGSSTNVSLTLRP CCCCCCCEEEEEECC | 24.27 | 28082515 | |
| 51 | N-linked_Glycosylation | LTLRPPLNATLVITF EEECCCCCEEEEEEE | 36.33 | 28082515 | |
| 66 | N-linked_Glycosylation | EITFRSKNITILELP EEEECCCCEEEEECC | 37.57 | 28082515 | |
| 84 | N-linked_Glycosylation | VVPPGVTNSSFQVTS EECCCCCCCCEEEEE | 33.00 | 28082515 | |
| 104 | N-linked_Glycosylation | LTVYLHGNHSNQTGP EEEEEECCCCCCCCC | 25.35 | 28082515 | |
| 107 | N-linked_Glycosylation | YLHGNHSNQTGPRIR EEECCCCCCCCCCEE | 35.56 | 28082515 | |
| 141 | Phosphorylation | YFVAWSISFYPQVIM HHHHHHHHHCHHHHH | 17.14 | - | |
| 143 | Phosphorylation | VAWSISFYPQVIMNW HHHHHHHCHHHHHHC | 5.98 | - | |
| 281 | Phosphorylation | LAVTLVKYFPQAYMN HHHHHHHHCCHHHHC | 17.01 | 24043423 | |
| 286 | Phosphorylation | VKYFPQAYMNFYYKS HHHCCHHHHCEEEEC | 6.32 | 24043423 | |
| 290 | Phosphorylation | PQAYMNFYYKSTEGW CHHHHCEEEECCCCC | 12.65 | 24043423 | |
| 291 | Phosphorylation | QAYMNFYYKSTEGWS HHHHCEEEECCCCCE | 8.37 | 24043423 | |
| 372 (in isoform 2) | Phosphorylation | - | - | ||
| 390 (in isoform 2) | Phosphorylation | - | 20639409 | ||
| 391 (in isoform 2) | Phosphorylation | - | 24719451 | ||
| 392 (in isoform 2) | Phosphorylation | - | 20639409 | ||
| 394 (in isoform 2) | Phosphorylation | - | 20639409 | ||
| 396 (in isoform 2) | Phosphorylation | - | 25159151 | ||
| 397 (in isoform 2) | Phosphorylation | - | 25159151 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CTNS_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CTNS_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CTNS_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of CTNS_HUMAN !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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