CTL3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CTL3_HUMAN
• UniProt AC: Q8N4M1
• Protein Name: Choline transporter-like protein 3
• Gene Name: SLC44A3
• Organism: Homo sapiens (Human).
• Sequence Length: 653
• Subcellular Localization: Membrane; Multi-pass membrane protein.
• Protein Sequence: MHCLGAEYLVSAEGAPRQREWRPQIYRKCTDTAWLFLFFLFWTGLVFIMGYSVVAGAAGRLLFGYDSFGNMCGKKNSPVEGAPLSGQDMTLKKHVFFMNSCNLEVKGTQLNRMALCVSNCPEEQLDSLEEVQFFANTSGSFLCVYSLNSFNYTHSPKADSLCPRLPVPPSKSFPLFNRCVPQTPECYSLFASVLINDVDTLHRILSGIMSGRDTILGLCILALALSLAMMFTFRFITTLLVHIFISLVILGLLFVCGVLWWLYYDYTNDLSIELDTERENMKCVLGFAIVSTGITAVLLVLIFVLRKRIKLTVELFQITNKAISSAPFLLFQPLWTFAILIFFWVLWVAVLLSLGTAGAAQVMEGGQVEYKPLSGIRYMWSYHLIGLIWTSEFILACQQMTIAGAVVTCYFNRSKNDPPDHPILSSLSILFFYHQGTVVKGSFLISVVRIPRIIVMYMQNALKEQQHGALSRYLFRCCYCCFWCLDKYLLHLNQNAYTTTAINGTDFCTSAKDAFKILSKNSSHFTSINCFGDFIIFLGKVLVVCFTVFGGLMAFNYNRAFQVWAVPLLLVAFFAYLVAHSFLSVFETVLDALFLCFAVDLETNDGSSEKPYFMDQEFLSFVKRSNKLNNARAQQDKHSLRNEEGTELQAIVR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
44 (in isoform 2)	Ubiquitination	-	15.50	21906983
51	Phosphorylation	GLVFIMGYSVVAGAA HHHHHHHHHHHHCHH	4.86	24043423
52	Phosphorylation	LVFIMGYSVVAGAAG HHHHHHHHHHHCHHH	12.37	24043423
56 (in isoform 3)	Ubiquitination	-	12.35	21906983
85	Phosphorylation	PVEGAPLSGQDMTLK CCCCCCCCCCCCEEC	33.09	22210691
90	Phosphorylation	PLSGQDMTLKKHVFF CCCCCCCEECEEEEE	43.65	22210691
92	Ubiquitination	SGQDMTLKKHVFFMN CCCCCEECEEEEEEC	31.50	2190698
92 (in isoform 1)	Ubiquitination	-	31.50	21906983
136	N-linked_Glycosylation	EEVQFFANTSGSFLC HHHHHHHCCCCCEEE	29.62	UniProtKB CARBOHYD
151	N-linked_Glycosylation	VYSLNSFNYTHSPKA EEECCCCCCCCCCCH	40.38	UniProtKB CARBOHYD
171	Ubiquitination	RLPVPPSKSFPLFNR CCCCCCCCCCCCCCC	62.99	-
374	Phosphorylation	QVEYKPLSGIRYMWS EEEEEECCCHHHHHH	40.47	24719451
412	N-linked_Glycosylation	AVVTCYFNRSKNDPP EEEEEEECCCCCCCC	22.35	UniProtKB CARBOHYD
503	N-linked_Glycosylation	AYTTTAINGTDFCTS CCCCCCCCCCCCCCC	44.86	UniProtKB CARBOHYD
521	N-linked_Glycosylation	AFKILSKNSSHFTSI HHHHHHCCCCCCEEC	45.42	UniProtKB CARBOHYD
639	Phosphorylation	RAQQDKHSLRNEEGT HHHHCHHHHHCCCCC	34.46	26657352
646	Phosphorylation	SLRNEEGTELQAIVR HHHCCCCCCHHHHCC	36.48	28857561

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CTL3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CTL3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CTL3_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of CTL3_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00122: Choline