CTGE2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CTGE2_HUMAN
• UniProt AC: Q96RT6
• Protein Name: cTAGE family member 2
• Gene Name: CTAGE1
• Organism: Homo sapiens (Human).
• Sequence Length: 745
• Subcellular Localization: Membrane ; Single-pass membrane protein .
• Protein Sequence: MRPDSHPYGFPWELVIRAAVAGFFAVLFLWRSFRSVTSRLYVRREKKFAVALSGLIEEKCKLLEKFSLVQKEYEGYEVESSLKNASFEKEATEAQSLEATCEKLNRFNSELVHEILCLEKELKEEKSKHSEQNELMADISKRIQSLEDESKSLKSQVAEAKMTFKRFQANEERLEIEIQDAWKENSELQESQKQLLQEAEVWKEQVSELIKQKRTFEDSKVHAEQVLNDKENHIKTLTERLLKMKDGVAMLEEDVTDDDNLELEMNSESEDGAYLDNPPKGALKKLIHAAKLNASLKTLEGERNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQSENTHFESENQKLQQKLKVMTELYQENEMKLYRKLIVEEKCRLEKEEKLSKVDEMISHATEELETYRKRAKDLKEFEKTIHFYQKKIILHEKKAHDNWSAAWTAERNLNDLRKENAHNRQKLTEIEFKIKLLEKDPYGLDVPNTAFGRQHSPYGPSPLGWPSSETRASLYPPTLLEGPLRLSPLLPRGGGRGSRGPGNPPDHQITKERGESSCDRLTDPHRAPSDAGPLAPPWEQDYRMMFPPPGQSYPDSALPPQRQDRFYSNCARLSGPAELRSFNMPSLDKMDGSMPSEMESSRNDTKDNLGNLKVPDSSLPAENEATGPGFVPPPLAPIRGLLFPVDTRGPFIRRGPPFPPPPPGTVFGASPDYFSPRDVPGPPRAPFAMRNVYLPRGFLPYRPPRPAFFPPAPTF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MRPDSHPYGFPW ---CCCCCCCCCCCH	29.10	23401153
8	Phosphorylation	MRPDSHPYGFPWELV CCCCCCCCCCCHHHH	26.44	23401153
35	Phosphorylation	FLWRSFRSVTSRLYV HHHHHHHHHHHHHHH	27.95	-
53	Phosphorylation	KKFAVALSGLIEEKC HHHHHHHHHHHHHHH	23.09	18452278
65	Ubiquitination	EKCKLLEKFSLVQKE HHHHHHHHHCCHHHH	39.98	-
67	Phosphorylation	CKLLEKFSLVQKEYE HHHHHHHCCHHHHHC	38.40	29396449
73	Phosphorylation	FSLVQKEYEGYEVES HCCHHHHHCCCCCCH	22.99	28796482
76	Phosphorylation	VQKEYEGYEVESSLK HHHHHCCCCCCHHHH	12.59	28796482
80	Phosphorylation	YEGYEVESSLKNASF HCCCCCCHHHHCCCH	46.26	30108239
81	Phosphorylation	EGYEVESSLKNASFE CCCCCCHHHHCCCHH	29.83	30108239
86	Phosphorylation	ESSLKNASFEKEATE CHHHHCCCHHHHHHH	43.25	30108239
92	Phosphorylation	ASFEKEATEAQSLEA CCHHHHHHHHHHHHH	32.71	30108239
96	Phosphorylation	KEATEAQSLEATCEK HHHHHHHHHHHHHHH	34.91	21815630
103	Ubiquitination	SLEATCEKLNRFNSE HHHHHHHHHHHCCHH	53.89	-
109	Phosphorylation	EKLNRFNSELVHEIL HHHHHCCHHHHHHHH	29.60	29396449
140	Phosphorylation	NELMADISKRIQSLE HHHHHHHHHHHHHHH	19.21	22210691
145	Phosphorylation	DISKRIQSLEDESKS HHHHHHHHHHHHHHH	31.21	22210691
150	Phosphorylation	IQSLEDESKSLKSQV HHHHHHHHHHHHHHH	39.61	22210691
152	Phosphorylation	SLEDESKSLKSQVAE HHHHHHHHHHHHHHH	50.76	22210691
154	Ubiquitination	EDESKSLKSQVAEAK HHHHHHHHHHHHHHH	46.03	-
267	Phosphorylation	NLELEMNSESEDGAY CCEEEECCCCCCCCC	40.98	24275569
269	Phosphorylation	ELEMNSESEDGAYLD EEEECCCCCCCCCCC	40.59	24275569
291	Ubiquitination	KKLIHAAKLNASLKT HHHHHHHHHCHHHHH	42.95	-
297	Ubiquitination	AKLNASLKTLEGERN HHHCHHHHHHHCCCC	48.87	-
392	Phosphorylation	SKVDEMISHATEELE HHHHHHHHHHHHHHH	13.03	25907765
395	Phosphorylation	DEMISHATEELETYR HHHHHHHHHHHHHHH	25.27	25907765
400	Phosphorylation	HATEELETYRKRAKD HHHHHHHHHHHHHHH	41.05	25907765
401	Phosphorylation	ATEELETYRKRAKDL HHHHHHHHHHHHHHH	12.54	25907765
414	Phosphorylation	DLKEFEKTIHFYQKK HHHHHHHHHHHHHHH	16.70	19413330
427	Ubiquitination	KKIILHEKKAHDNWS HHHEEEEHHCCCCHH	44.50	21890473
458	Phosphorylation	AHNRQKLTEIEFKIK CCCHHHHHHEEHHHH	41.79	24114839
486	Phosphorylation	TAFGRQHSPYGPSPL CCCCCCCCCCCCCCC	16.10	28302921
488	Phosphorylation	FGRQHSPYGPSPLGW CCCCCCCCCCCCCCC	44.69	19845377
491	Phosphorylation	QHSPYGPSPLGWPSS CCCCCCCCCCCCCCH	28.52	22496350
517	Phosphorylation	LEGPLRLSPLLPRGG CCCCCEECCCCCCCC	13.68	23403867
546	Phosphorylation	ITKERGESSCDRLTD CCHHHCCCCHHCCCC	38.81	25850435
547	Phosphorylation	TKERGESSCDRLTDP CHHHCCCCHHCCCCC	18.74	25850435
552	Phosphorylation	ESSCDRLTDPHRAPS CCCHHCCCCCCCCCC	48.67	25850435
582	Phosphorylation	MFPPPGQSYPDSALP CCCCCCCCCCCCCCC	44.54	24275569
583	Phosphorylation	FPPPGQSYPDSALPP CCCCCCCCCCCCCCH	11.81	24275569
604	Phosphorylation	YSNCARLSGPAELRS HHCCHHCCCCHHHHH	36.86	23401153
611	Phosphorylation	SGPAELRSFNMPSLD CCCHHHHHCCCCCHH	33.33	23927012
616	Phosphorylation	LRSFNMPSLDKMDGS HHHCCCCCHHCCCCC	38.13	23927012
623	Phosphorylation	SLDKMDGSMPSEMES CHHCCCCCCCHHHHH	24.21	23401153
626	Phosphorylation	KMDGSMPSEMESSRN CCCCCCCHHHHHCCC	40.72	29083192
630	Phosphorylation	SMPSEMESSRNDTKD CCCHHHHHCCCCCCC	33.03	30576142
631	Phosphorylation	MPSEMESSRNDTKDN CCHHHHHCCCCCCCC	23.07	22115753
635	Phosphorylation	MESSRNDTKDNLGNL HHHCCCCCCCCCCCC	43.79	22115753
647	Phosphorylation	GNLKVPDSSLPAENE CCCCCCCCCCCCCCC	27.92	22210691
648	Phosphorylation	NLKVPDSSLPAENEA CCCCCCCCCCCCCCC	45.83	22210691
677	Phosphorylation	GLLFPVDTRGPFIRR CCEEECCCCCCCHHC	37.45	22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CTGE2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CTGE2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CTGE2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of CTGE2_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-414, AND MASSSPECTROMETRY.
PubMed: 19413330