CTC1_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CTC1_ARATH
• UniProt AC: D0EL35
• Protein Name: CST complex subunit CTC1 {ECO:0000303|PubMed:19854131}
• Gene Name: CTC1 {ECO:0000303|PubMed:19854131}
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 1272
• Subcellular Localization: Nucleus . Chromosome, telomere .
• Protein Description: Component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. [PubMed: 19854131 Associates with enzymatically active telomerase]
• Protein Sequence: MENTTILTVKDLVNEGIAVTGASSLFSSAASHSSSESTSTNPKSHPGAVDSDFSRKFLTPLNYPTVIFGTVALPSETLKCPNRYCFRFTDGDLTICCDILGFEFRAIGSKICVLSWNFLPMNHSGGFLEIINWKFVDSGSLLSRCSGISSFPLIPSLYSSQNGDRKSRYSVCGVLESISPVSVVPCMDGVSSDSVNLPGFLVHVMACECKVYSRDAIDCGHAFERSVFVYFCGLEAASWHPVVMKLVGRNVALSGLKRKLVYVRGDSLLVFVTTENSVLHPPWLSKKGTVSKTVVDRRGNCGSYRGYVRGLYLKGKLVEMDEDVWLLLTDQILNRSHSIRTGSLIFIRNVHFVNTKFPWGEVLILGACFKTSITVEFFSPFETSCLVDSCRQTSLSLYVESLSFPARLWTLLVRISFEKFNRMPSDKEILRSCQKDELTKMYAESRIPPSMFQPRGGIFTEFCMHESCGCNSEARDCNLKLVMPISSFVHHVKVMLNELLSQIKKDFSASDCLSHSSSTWKRYNNTNPKTLRSEDTGVILLGRLKISSSGRLQLHDRTSSIDVLTPDLLSDRNASRICEVPDYYLIIEGIPESMLHMPFLKNPFRCSSVLNPTPLAIKNTLTVPFSLSLGTASCKHLLKHHPFDWRHDFNEFKEGFFHLFRVTHKFPILKNGHPGMPDCTSVFIEALVLPWDLICTVTEEEAAAPNFEEHDTSQEIRPHKRCKTNNGLQSQSFLSVPHEISCQMTIRCASSHCLVATATLSNLTENKSGKMHSAMRVLLEFIPECSNYYGLQIGGCYLMKHGSDDSFCVGRSGISNNDKINFRPETRLWSLEFSFDEVLTHDGSMDVHPLVSSQPSFAVEQQNVSSRQPCSDVSLLLPYDAKGLFSVFLNDLEGLNKPLAAGKDNNNISCCTQSETIMHAEPSRLLPSNSLFPEGNLATFRGDVVAVDAVTSSVVDVSSSYCINVLVNHQMVKIFGPLRRHSYLTGFGFGTNATFYRILGTGEQNSFVLTSASFIKINSRKALDSPPLEKPTHGAALCLPKITPQEFVPCILAGPACNSFSGNEDNQQIKFACKVLSVYLLVLQTRSDDPSENECRNNIDIPLAGFVVDDGSSTYLCWTSGERAFTILRLHEELPEETIDVVQWTRRYSNWGTTAYHLDQIVRVHKRIVMKCNGSQIDVLFQDITIAVTSDQLLTKSEDKFLKWLILNAISGPIWEVAASSMDMKMIEHLEREQCVEMETSRYNLQSVWGNEVCQVDPLVRAWSLLQGLLNS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
156	Phosphorylation	SSFPLIPSLYSSQNG CCCCCCHHHHCCCCC	32.71	23572148
372	Phosphorylation	LGACFKTSITVEFFS EEEEEECEEEEEECC	19.49	28011693
374	Phosphorylation	ACFKTSITVEFFSPF EEEECEEEEEECCCC	17.47	28011693
1185	Phosphorylation	DVLFQDITIAVTSDQ EEEECCEEEEECCCC	15.92	24601666
1189	Phosphorylation	QDITIAVTSDQLLTK CCEEEEECCCCCCCC	19.98	24601666
1190	Phosphorylation	DITIAVTSDQLLTKS CEEEEECCCCCCCCC	19.43	24601666
1195	Phosphorylation	VTSDQLLTKSEDKFL ECCCCCCCCCHHHHH	40.91	24601666

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CTC1_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CTC1_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CTC1_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
STN1_ARATH	STN1	physical	19854131

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.