CTBP2_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CTBP2_RAT
• UniProt AC: Q9EQH5
• Protein Name: C-terminal-binding protein 2
• Gene Name: Ctbp2
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 445
• Subcellular Localization: Nucleus . Cell junction, synapse.
• Protein Description: Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation. Isoform 2 probably acts as a scaffold for specialized synapses (By similarity)..
• Protein Sequence: MALVDKHKVKRQRLDRICEGIRPQIMNGPLHPRPLVALLDGRDCTVEMPILKDLATVAFCDAQSTQEIHEKVLNEAVGAMMYHTITLTREDLEKFKALRVIVRIGSGYDNVDIKAAGELGIAVCNIPSAAVEETADSTVCHILNLYRRNTWLYQALREGTRVQSVEQIREVASGAARIRGETLGLIGFGRTGQAVAVRAKAFGFSVIFYDPYLQDGIERSLGVQRVYTLQDLLYQSDCVSLHCNLNEHNHHLINDFTIKQMRQGAFLVNAARGGLVDEKALAQALKEGRIRGAALDVHESEPFSFAQGPLKDAPNLICTPHTAWYSEQASLEMREAAATEIRRAITGRIPESLRNCVNKEFFVTSTPWSVIDQQAIHPELNGATYRYPPGIVGVAPGGLPPAMEGIIPGGIPVTHNLPTVAHPSQAPSPNQPTKHGDNREHPNEQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5 (in isoform 2)	Phosphorylation	-	48.46	22673903
22	Asymmetric dimethylarginine	DRICEGIRPQIMNGP HHHHHCCCHHHHCCC	28.11	-
22	Methylation	DRICEGIRPQIMNGP HHHHHCCCHHHHCCC	28.11	-
164	Phosphorylation	REGTRVQSVEQIREV HCCCCCCCHHHHHHH	25.43	22366688
279	Ubiquitination	RGGLVDEKALAQALK CCCCCCHHHHHHHHH	44.21	-
341 (in isoform 2)	Phosphorylation	-	2.91	23984901
342 (in isoform 2)	Phosphorylation	-	18.75	23984901
345 (in isoform 2)	Phosphorylation	-	3.88	23984901
414	Phosphorylation	IPGGIPVTHNLPTVA CCCCCCCCCCCCCCC	10.33	22668510
419	Phosphorylation	PVTHNLPTVAHPSQA CCCCCCCCCCCCCCC	33.23	22668510
424	Phosphorylation	LPTVAHPSQAPSPNQ CCCCCCCCCCCCCCC	29.16	28432305
428	Phosphorylation	AHPSQAPSPNQPTKH CCCCCCCCCCCCCCC	39.23	28432305
433	Phosphorylation	APSPNQPTKHGDNRE CCCCCCCCCCCCCCC	26.38	21630457
506 (in isoform 2)	Phosphorylation	-		22673903
510 (in isoform 2)	Phosphorylation	-		22673903

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
428	S	Phosphorylation	Kinase	HIPK2	-	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
428	S	Phosphorylation	Phosphorylation by HIPK2 on Ser-428 induces proteasomal degradation.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CTBP2_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of CTBP2_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.