CSRN3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CSRN3_HUMAN
• UniProt AC: Q8WYN3
• Protein Name: Cysteine/serine-rich nuclear protein 3
• Gene Name: CSRNP3
• Organism: Homo sapiens (Human).
• Sequence Length: 585
• Subcellular Localization: Nucleus.
• Protein Description: Binds to the consensus sequence 5'-AGAGTG-3' and has transcriptional activator activity. Plays a role in apoptosis (By similarity)..
• Protein Sequence: MSGILKRKFEEVDGSSPCSSVRESDDEVSSSESADSGDSVNPSTSSHFTPSSILKREKRLRTKNVHFSCVTVYYFTRRQGFTSVPSQGGSTLGMSSRHNSVRQYTLGEFAREQERLHREMLREHLREEKLNSLKLKMTKNGTVESEEASTLTLDDISDDDIDLDNTEVDEYFFLQPLPTKKRRALLRASGVKKIDVEEKHELRAIRLSREDCGCDCRVFCDPDTCTCSLAGIKCQVDRMSFPCGCTKEGCSNTAGRIEFNPIRVRTHFLHTIMKLELEKNREQQIPTLNGCHSEISAHSSSMGPVAHSVEYSIADSFEIETEPQAAVLHLQSAEELDCQGEEEEEEEDGSSFCSGVTDSSTQSLAPSESDEEEEEEEEEEEEEDDDDDKGDGFVEGLGTHAEVVPLPSVLCYSDGTAVHESHAKNASFYANSSTLYYQIDSHIPGTPNQISENYSERDTVKNGTLSLVPYTMTPEQFVDYARQAEEAYGASHYPAANPSVIVCCSSSENDSGVPCNSLYPEHRSNHPQVEFHSYLKGPSQEGFVSALNGDSHISEHPAENSLSLAEKSILHEECIKSPVVETVPV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
29	Phosphorylation	RESDDEVSSSESADS CCCCCCCCCCCCCCC	26.54	-
30	Phosphorylation	ESDDEVSSSESADSG CCCCCCCCCCCCCCC	43.21	-
31	Phosphorylation	SDDEVSSSESADSGD CCCCCCCCCCCCCCC	28.23	-
51	Phosphorylation	TSSHFTPSSILKREK CCCCCCHHHHHHHHH	27.27	-
52	Phosphorylation	SSHFTPSSILKREKR CCCCCHHHHHHHHHH	32.89	24719451
62	Phosphorylation	KREKRLRTKNVHFSC HHHHHHHCCCCCEEE	31.40	22210691
74	Phosphorylation	FSCVTVYYFTRRQGF EEEEEEEEEECCCCC	8.30	22210691
82	Phosphorylation	FTRRQGFTSVPSQGG EECCCCCEECCCCCC	35.32	24114839
95	Phosphorylation	GGSTLGMSSRHNSVR CCCCCCCCCCCCCCH	23.56	24114839
96	Phosphorylation	GSTLGMSSRHNSVRQ CCCCCCCCCCCCCHH	28.77	24114839
104	Phosphorylation	RHNSVRQYTLGEFAR CCCCCHHHCHHHHHH	8.05	-
179	Phosphorylation	FFLQPLPTKKRRALL EECCCCCCHHHHHHH	57.81	22964224
192	Acetylation	LLRASGVKKIDVEEK HHHHHCCCCCCHHHH	47.76	11790901
193	Acetylation	LRASGVKKIDVEEKH HHHHCCCCCCHHHHH	41.55	11790911
199	Acetylation	KKIDVEEKHELRAIR CCCCHHHHHHHHHHC	28.95	11790921
274	Ubiquitination	HFLHTIMKLELEKNR HHHHHHHHHHHHHCH	34.65	-
561	Phosphorylation	SEHPAENSLSLAEKS CCCCCCCCCCHHHHH	15.73	19690332
563	Phosphorylation	HPAENSLSLAEKSIL CCCCCCCCHHHHHHC	25.92	19690332
577	Phosphorylation	LHEECIKSPVVETVP CCHHHHCCCCEEECC	11.74	29978859
582	Phosphorylation	IKSPVVETVPV---- HCCCCEEECCC----	20.64	29978859

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CSRN3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CSRN3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CSRN3_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of CSRN3_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-561 AND SER-563, ANDMASS SPECTROMETRY.
PubMed: 19690332