CSN1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CSN1_RAT
• UniProt AC: P97834
• Protein Name: COP9 signalosome complex subunit 1
• Gene Name: Gps1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 471
• Subcellular Localization: Cytoplasm. Nucleus.
• Protein Description: Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction (By similarity)..
• Protein Sequence: MQIDVDPQEDPQNAPDVNYVVENPTLDLEQYAASYSGLMRIERLQFIADRCPPLRVEALKMALSFVQRTFNVDMYEEIHRKLSEATRELQNAPDAIPESGVEPPPLDTAWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRRGHDDLGDHYLDCGDLSNALKCYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLSYVSKAESTPEIAEQRGERDSQTQAILTKLKCAAGLAELAARKYKQAAKCFLLASFDHCDFPELLSPSNVAVYGGLCALATFDRQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKYASCLKMLDEMKDNLLLDMYLAPHVRTLYTQIRNRALIQYFSPYVSADMHKMAAAFNTTVAALEDELTQVILEGLINARIDSHSKILYARDVDQRSTTFEKSLLMGKEFQRRAKAMILRAAVLRNQIHVKSPPREGSQGELTPANSQSRMSTNM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
121	Acetylation	TRKKALLKLEKLDTD HHHHHHHHHHHHCCC	56.29	22902405
124	Acetylation	KALLKLEKLDTDLKN HHHHHHHHHCCCHHC	63.20	22902405
220	Phosphorylation	EQRGERDSQTQAILT HHHCCCHHHHHHHHH	41.15	27097102
222	Phosphorylation	RGERDSQTQAILTKL HCCCHHHHHHHHHHH	24.74	27097102
227	Phosphorylation	SQTQAILTKLKCAAG HHHHHHHHHHHHHHH	28.37	25575281
448	Phosphorylation	RNQIHVKSPPREGSQ HCCCCCCCCCCCCCC	38.76	27097102
454	Phosphorylation	KSPPREGSQGELTPA CCCCCCCCCCCCCCC	30.20	28689409
459	Phosphorylation	EGSQGELTPANSQSR CCCCCCCCCCCCCCC	18.96	29779826
463	Phosphorylation	GELTPANSQSRMSTN CCCCCCCCCCCCCCC	31.47	29779826
465	Phosphorylation	LTPANSQSRMSTNM- CCCCCCCCCCCCCC-	29.76	27097102

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CSN1_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CSN1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CSN1_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of CSN1_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.