CSK23_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CSK23_HUMAN
• UniProt AC: Q8NEV1
• Protein Name: Casein kinase II subunit alpha 3
• Gene Name: CSNK2A3
• Organism: Homo sapiens (Human).
• Sequence Length: 391
• Protein Description: Probable catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Amplification-dependent oncogene; promotes cell proliferation and tumorigenesis by down-regulating expression of the tumor suppressor protein, PML. May play a role in the pathogenesis of the lung cancer development and progression..
• Protein Sequence: MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWRLGCMLASMIFRKEPFFHGRDNYDQLVRIAKFLGTEDLYGYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANVMSGISSVPTPSPLGPLAGSPVIAAANPLGMPVPAATGAQQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSGPVPSRA ------CCCCCCCCC		17192257
7	Phosphorylation	-MSGPVPSRARVYTD -CCCCCCCCCEEEEE		19369195
12	Phosphorylation	VPSRARVYTDVNTHR CCCCCEEEEECCCCC		28152594
13	Phosphorylation	PSRARVYTDVNTHRP CCCCEEEEECCCCCC		28152594
17	Phosphorylation	RVYTDVNTHRPREYW EEEEECCCCCCHHHC		28152594
44	Ubiquitination	DDYQLVRKLGRGKYS HHHHHHHHHCCCCHH		22817900
49	Acetylation	VRKLGRGKYSEVFEA HHHHCCCCHHHHHHE		-
49	Ubiquitination	VRKLGRGKYSEVFEA HHHHCCCCHHHHHHE		21906983
50	Phosphorylation	RKLGRGKYSEVFEAI HHHCCCCHHHHHHEE		28152594
51	Phosphorylation	KLGRGKYSEVFEAIN HHCCCCHHHHHHEEE		28152594
60	Phosphorylation	VFEAINITNNEKVVV HHHEEECCCCCEEEE		20071362
64	Ubiquitination	INITNNEKVVVKILK EECCCCCEEEEEEEH		33845483
68	Ubiquitination	NNEKVVVKILKPVKK CCCEEEEEEEHHHCH		29967540
71	Ubiquitination	KVVVKILKPVKKKKI EEEEEEEHHHCHHHH		-
83	Ubiquitination	KKIKREIKILENLRG HHHHHHHHHHHHCCC		24816145
89	Methylation	IKILENLRGGPNIIT HHHHHHCCCCCCEEE		-
102	Acetylation	ITLADIVKDPVSRTP EEHHHHHCCCCCCCC		-
102	Ubiquitination	ITLADIVKDPVSRTP EEHHHHHCCCCCCCC		23000965
122	Ubiquitination	HVNNTDFKQLYQTLT ECCCCCHHHHHHHHC		21963094
125	Phosphorylation	NTDFKQLYQTLTDYD CCCHHHHHHHHCHHH		28152594
127	Phosphorylation	DFKQLYQTLTDYDIR CHHHHHHHHCHHHHH		28152594
129	Phosphorylation	KQLYQTLTDYDIRFY HHHHHHHCHHHHHHH		28152594
131	Phosphorylation	LYQTLTDYDIRFYMY HHHHHCHHHHHHHHH		24043423
158	Ubiquitination	GIMHRDVKPHNVMID CCCCCCCCCCCEEEE		24816145
182	Phosphorylation	DWGLAEFYHPGQEYN HHHHHCCCCCCCCEE		11439109
188	Phosphorylation	FYHPGQEYNVRVASR CCCCCCCEEEEEECH		29496907
194	Phosphorylation	EYNVRVASRYFKGPE CEEEEEECHHCCCCE		28355574
196	Phosphorylation	NVRVASRYFKGPELL EEEEECHHCCCCEEE		23186163
209	Phosphorylation	LLVDYQMYDYSLDMW EEEEEECCCCHHHHH		-
229	Ubiquitination	LASMIFRKEPFFHGR HHHHHHHCCCCCCCC		22817900
255	Phosphorylation	FLGTEDLYGYIDKYN HHCCHHHHHHHHHHC		19369195
277	Phosphorylation	NDILGRHSRKRWERF HHHCCHHHHHHHHHH		19369195
287	Phosphorylation	RWERFVHSENQHLVS HHHHHCCCCCCCCCC		30266825
303	Ubiquitination	EALDFLDKLLRYDHQ HHHHHHHHHHCCCHH		-
323	Phosphorylation	REAMEHPYFYTVVKD HHHHHCCCEEEEEEC		29496907
326	Phosphorylation	MEHPYFYTVVKDQAR HHCCCEEEEEECCCC		29496907
329	Acetylation	PYFYTVVKDQARMGS CCEEEEEECCCCCCC		80471083
329	Ubiquitination	PYFYTVVKDQARMGS CCEEEEEECCCCCCC		21906983
343	Phosphorylation	SSSMPGGSTPVSSAN CCCCCCCCCCCCCCC		20068231
344	Phosphorylation	SSMPGGSTPVSSANV CCCCCCCCCCCCCCC		-
360	Phosphorylation	SGISSVPTPSPLGPL CCCCCCCCCCCCCCC		7592773
362	Phosphorylation	ISSVPTPSPLGPLAG CCCCCCCCCCCCCCC		7592773
370	Phosphorylation	PLGPLAGSPVIAAAN CCCCCCCCCEEEEEC		7592773

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CSK23_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CSK23_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CSK23_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PML_HUMAN	PML	physical	14522971
PML_HUMAN	PML	physical	20625391

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.