CSC1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CSC1_HUMAN
• UniProt AC: Q9P1W3
• Protein Name: Calcium permeable stress-gated cation channel 1
• Gene Name: TMEM63C
• Organism: Homo sapiens (Human).
• Sequence Length: 806
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Description: Acts as an osmosensitive calcium-permeable cation channel..
• Protein Sequence: MSASPDDLSTGGRLQNMTVDECFQSRNTVLQGQPFGGVPTVLCLNIALWVLVLVVYSFLRKAAWDYGRLALLIHNDSLTSLIYGEQSEKTSPSETSLEMERRDKGFCSWFFNSITMKDEDLINKCGDDARIYIVFQYHLIIFVLIICIPSLGIILPINYTGSVLDWSSHFARTTIVNVSTESKLLWLHSLLSFFYFITNFMFMAHHCLGFAPRNSQKVTRTLMITYVPKDIEDPELIIKHFHEAYPGSVVTRVHFCYDVRNLIDLDDQRRHAMRGRLFYTAKAKKTGKVMIRIHPCARLCFCKCWTCFKEVDAEQYYSELEEQLTDEFNAELNRVPLKRLDLIFVTFQDSRMAKRVRKDYKYVQCGVQPQQSSVTTIVKSYYWRVTMAPHPKDIIWKHLSVRRFFWWARFIAINTFLFFLFFFLTTPAIIMNTIDMYNVTRPIEKLQNPIVTQFFPSVMLWGFTVILPLIVYFSAFLEAHWTRSSQNLVMVHKCYIFLVFMVVILPSMGLTSLDVFLRWLFDIYYLEQASIRFQCVFLPDNGAFFVNYVITAALLGTGMELLRLGSLFCYSTRLFFSRSEPERVNIRKNQAIDFQFGREYAWMMNVFSVVMAYSITCPIIVPFGLLYLCMKHLTDRYNMYYSFAPTKLNEQIHMAAVSQAIFAPLLGLFWMLFFSILRLGSLHAITIFSLSTLLIAMVIAFVGIFLGKLRMVADYEPEEEEIQTVFDMEPSSTSSTPTSLLYVATVLQEPELNLTPASSPARHTYGTMNNQPEEGEEESGLRGFARELDSAQFQEGLELEGQNQYH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
77	Phosphorylation	ALLIHNDSLTSLIYG EEEEECCCHHHHHHC		26657352
79	Phosphorylation	LIHNDSLTSLIYGEQ EEECCCHHHHHHCCC		29691806
80	Phosphorylation	IHNDSLTSLIYGEQS EECCCHHHHHHCCCC		26657352
83	Phosphorylation	DSLTSLIYGEQSEKT CCHHHHHHCCCCCCC		27732954
90	Phosphorylation	YGEQSEKTSPSETSL HCCCCCCCCCCCCCH		27732954
91	Phosphorylation	GEQSEKTSPSETSLE CCCCCCCCCCCCCHH		27732954
93	Phosphorylation	QSEKTSPSETSLEME CCCCCCCCCCCHHHH		27732954
95	Phosphorylation	EKTSPSETSLEMERR CCCCCCCCCHHHHHC		27732954
96	Phosphorylation	KTSPSETSLEMERRD CCCCCCCCHHHHHCC		27732954
173	Phosphorylation	WSSHFARTTIVNVST HHHCCCCEEEEECCC		22210691
174	Phosphorylation	SSHFARTTIVNVSTE HHCCCCEEEEECCCH		22210691
180	Phosphorylation	TTIVNVSTESKLLWL EEEEECCCHHHHHHH		-
219	Phosphorylation	PRNSQKVTRTLMITY CCCCCCEEEEEEEEE		25072903
221	Phosphorylation	NSQKVTRTLMITYVP CCCCEEEEEEEEEEC		25072903
225	Phosphorylation	VTRTLMITYVPKDIE EEEEEEEEEECCCCC		25072903
226	Phosphorylation	TRTLMITYVPKDIED EEEEEEEEECCCCCC		25072903
317	Phosphorylation	EVDAEQYYSELEEQL CCCHHHHHHHHHHHH		-
325	Phosphorylation	SELEEQLTDEFNAEL HHHHHHHHHHHHHHH		-
362	Phosphorylation	RVRKDYKYVQCGVQP HHHHCCCEECCCCCC		-
641	Phosphorylation	TDRYNMYYSFAPTKL HHHCCCCCCCCCCHH		-
646	Phosphorylation	MYYSFAPTKLNEQIH CCCCCCCCHHCHHHH		-
790	Phosphorylation	GFARELDSAQFQEGL HHHHHHCHHHHHHHC		30266825
805	Phosphorylation	ELEGQNQYH------ CCCCCCCCC------		27642862

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CSC1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CSC1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CSC1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of CSC1_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.