CPLX2_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CPLX2_RAT
• UniProt AC: P84087
• Protein Name: Complexin-2
• Gene Name: Cplx2
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 134
• Subcellular Localization: Cytoplasm, cytosol. Cell junction, synapse. Nucleus. Enriched at synaptic-releasing sites in mature neurons. In mast cells, cytosol and nucleus. Becomes enriched near plasma membrane following stimulation.
• Protein Description: Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Also involved in mast cell exocytosis. [PubMed: 15870114]
• Protein Sequence: MDFVMKQALGGATKDMGKMLGGEEEKDPDAQKKEEERQEALRQQEEERKAKHARMEAEREKVRQQIRDKYGLKKKEEKEAEEKAALEQPCEGSLTRPKKAIPAGCGDEEEEEEESILDTVLKYLPGPLQDMFKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Acetylation	QALGGATKDMGKMLG HHCCCCCHHHHHHCC	45.22	22648221
69	Acetylation	VRQQIRDKYGLKKKE HHHHHHHHHCCCHHH	31.22	22902405
90	S-nitrosocysteine	KAALEQPCEGSLTRP HHHHCCCCCCCCCCC	10.39	-
90	S-nitrosylation	KAALEQPCEGSLTRP HHHHCCCCCCCCCCC	10.39	16418269
93	Phosphorylation	LEQPCEGSLTRPKKA HCCCCCCCCCCCCCC	12.32	30411139
95	Phosphorylation	QPCEGSLTRPKKAIP CCCCCCCCCCCCCCC	46.77	28432305
115	Phosphorylation	EEEEEEESILDTVLK HHHHHHHHHHHHHHH	31.56	17266930

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
115	S	Phosphorylation	Kinase	CK2-FAMILY	-	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
93	S	Phosphorylation	Ser-93 is dephosphorylated by PP2A.	16499873

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CPLX2_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of CPLX2_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Identification of okadaic acid-induced phosphorylation events by amass spectrometry approach.";
Hill J.J., Callaghan D.A., Ding W., Kelly J.F., Chakravarthy B.R.;
Biochem. Biophys. Res. Commun. 342:791-799(2006).
Cited for: PROTEIN SEQUENCE OF 84-122, PHOSPHORYLATION AT SER-93, AND MASSSPECTROMETRY.
PubMed: 16499873