CPL3_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CPL3_ARATH
• UniProt AC: Q8LL04
• Protein Name: RNA polymerase II C-terminal domain phosphatase-like 3
• Gene Name: CPL3
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 1241
• Subcellular Localization: Nucleus .
• Protein Description: Processively dephosphorylates 'Ser-2' and/or 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (RPB1). This promotes the activity of RNA polymerase II (By similarity). Negative regulator of stress gene transcription involved in abscisic acid (ABA) mediated signaling pathway and cold resistance..
• Protein Sequence: MLVARSGCSRTLIRMGNDENLMVMVDVEEGEIPDSVNTEIEVKHKSTTTTADVGGDVDVGVVAGGRGGGGGGSNGNSRVWTMEELISQYPAYRPYANSGLSNLAWARAVQNKPFNEGLVMDYEPRESDKIVIEDSDDEKEEGELEEGEIDLVDNASDDNLVEKDTESVVLISADKVEDDRILKERDLEKKVKLIRGVLESTSLVEAQTGFEGVCSRILGALESLRELVSDNDDFPKRDTLVQLSFASLQTINYVFCSMNNISKERNKETMSRLLTLVNDHFSQFLSFNQKNEIETMNQDLSRSAIAVFAGTSSEENVNQMTQPSNGDSFLAKKLTSESTHRGAAYLRSRLPMLPLLDLHKDHDADSLPSPTRETTPSLPVNGRHTMVRPGFPVGRESQTTEGAKVYSYESDARKAVSTYQQKFGLNSVFKTDDLPSPTPSGEPNDGNGDVGGEVSSSVVKSSNPGSHLIYGQDVPLPSNFNSRSMPVANSVSSTVPPHHLSIHAISAPTASDQTVKPSAKSRDPRLRLAKPDAANVTIYSYSSGDARNLSKVELSADLVNPRKQKAADEFLIDGPAWKRQKSDTDAPKAAGTGGWLEDTESSGLLKLESKPRLIENGVTSMTSSVMPTSAVSVSQKVRTASTDTASLQSLLKDIAVNPTMLLNLLKMGERQKVPEKAIQKPMDPRRAAQLPGSSVQPGVSTPLSIPASNALAANSLNSGVLQDSSQNAPAAESGSIRMKPRDPRRILHGSTLQRTDSSMEKQTKVNDPSTLGTLTMKGKAEDLETPPQLDPRQNISQNGTSKMKISGELLSGKTPDFSTQFTKNLKSIADMVVVSQQLGNPPASMHSVQLKTERDVKHNPSNPNAQDEDVSVSAASVTAAAGPTRSMNSWGDVEHLFEGYDDIQRVAIQRERVRRLEEQNKMFASQKLSLVLDIDHTLLNSAKFNEVESRHEEILRKKEEQDREKPYRHLFRFLHMGMWTKLRPGIWNFLEKASKLYELHLYTMGNKLYATEMAKLLDPKGVLFNGRVISKGDDGDPLDGDERVPKSKDLEGVMGMESSVVIIDDSVRVWPQHKMNLIAVERYLYFPCSRRQFGLLGPSLLELDRDEVPEEGTLASSLAVIEKIHQNFFSHTSLDEVDVRNILASEQRKILAGCRIVFSRIIPVGEAKPHLHPLWQTAEQFGAVCTTQVDEHVTHVVTNSLGTDKVNWALTRGRFVVHPGWVEASAFLYQRANENLYAINP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
135	Phosphorylation	DKIVIEDSDDEKEEG CCEEEECCCCCCCCC	33.88	23776212
366	Phosphorylation	HKDHDADSLPSPTRE CCCCCCCCCCCCCCC	43.85	19376835
369	Phosphorylation	HDADSLPSPTRETTP CCCCCCCCCCCCCCC	44.17	30291188
371	Phosphorylation	ADSLPSPTRETTPSL CCCCCCCCCCCCCCC	45.54	19376835
431	Phosphorylation	GLNSVFKTDDLPSPT CCCCCEECCCCCCCC	24.23	30407730
436	Phosphorylation	FKTDDLPSPTPSGEP EECCCCCCCCCCCCC	49.02	30407730
438	Phosphorylation	TDDLPSPTPSGEPND CCCCCCCCCCCCCCC	34.13	30407730
440	Phosphorylation	DLPSPTPSGEPNDGN CCCCCCCCCCCCCCC	59.26	30407730
490	Phosphorylation	RSMPVANSVSSTVPP CCCCCCCCCCCCCCC	17.40	25368622
492	Phosphorylation	MPVANSVSSTVPPHH CCCCCCCCCCCCCCC	21.80	25368622
493	Phosphorylation	PVANSVSSTVPPHHL CCCCCCCCCCCCCCC	31.13	25368622
494	Phosphorylation	VANSVSSTVPPHHLS CCCCCCCCCCCCCCE	29.53	25368622
501	Phosphorylation	TVPPHHLSIHAISAP CCCCCCCEEEEEECC	14.15	25368622

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CPL3_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CPL3_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CPL3_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NRPB1_ARATH	NRPB1	physical	25464831

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.