CP26B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CP26B_HUMAN
• UniProt AC: Q9NR63
• Protein Name: Cytochrome P450 26B1
• Gene Name: CYP26B1
• Organism: Homo sapiens (Human).
• Sequence Length: 512
• Subcellular Localization: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
• Protein Description: Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Involved in the specific inactivation of all-trans-retinoic acid (all-trans-RA), with a preference for the following substrates: all-trans-RA > 9-cis-RA > 13-cis-RA. Generates several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH-RA. Essential for postnatal survival. Plays a central role in germ cell development: acts by degrading RA in the developing testis, preventing STRA8 expression, thereby leading to delay of meiosis. Required for the maintenance of the undifferentiated state of male germ cells during embryonic development in Sertoli cells, inducing arrest in G0 phase of the cell cycle and preventing meiotic entry. Plays a role in skeletal development, both at the level of patterning and in the ossification of bone and the establishment of some synovial joints.; Has also a significant activity in oxidation of tazarotenic acid and may therefore metabolize that xenobiotic in vivo..
• Protein Sequence: MLFEGLDLVSALATLAACLVSVTLLLAVSQQLWQLRWAATRDKSCKLPIPKGSMGFPLIGETGHWLLQGSGFQSSRREKYGNVFKTHLLGRPLIRVTGAENVRKILMGEHHLVSTEWPRSTRMLLGPNTVSNSIGDIHRNKRKVFSKIFSHEALESYLPKIQLVIQDTLRAWSSHPEAINVYQEAQKLTFRMAIRVLLGFSIPEEDLGHLFEVYQQFVDNVFSLPVDLPFSGYRRGIQARQILQKGLEKAIREKLQCTQGKDYLDALDLLIESSKEHGKEMTMQELKDGTLELIFAAYATTASASTSLIMQLLKHPTVLEKLRDELRAHGILHSGGCPCEGTLRLDTLSGLRYLDCVIKEVMRLFTPISGGYRTVLQTFELDGFQIPKGWSVMYSIRDTHDTAPVFKDVNVFDPDRFSQARSEDKDGRFHYLPFGGGVRTCLGKHLAKLFLKVLAVELASTSRFELATRTFPRITLVPVLHPVDGLSVKFFGLDSNQNEILPETEAMLSATV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
129	Phosphorylation	RMLLGPNTVSNSIGD CCCCCCCCCCCCHHH	28.57	22468782
131	Phosphorylation	LLGPNTVSNSIGDIH CCCCCCCCCCHHHHH	23.87	22468782
275	Ubiquitination	DLLIESSKEHGKEMT HHHHHHHHHHHCCCC	64.11	-
290	Phosphorylation	MQELKDGTLELIFAA HHHHHHCHHHHHHHH	27.48	-
298	Phosphorylation	LELIFAAYATTASAS HHHHHHHHHHCCCCC	10.89	-
317	Phosphorylation	MQLLKHPTVLEKLRD HHHHCCHHHHHHHHH	37.13	-
321	Ubiquitination	KHPTVLEKLRDELRA CCHHHHHHHHHHHHH	44.66	-
349	Phosphorylation	TLRLDTLSGLRYLDC EEEEECCCHHHHHHH	37.56	24719451
395	Phosphorylation	KGWSVMYSIRDTHDT CCEEEEEEEECCCCC	7.95	24719451
422	Phosphorylation	DRFSQARSEDKDGRF HHHHHCCCCCCCCCE	53.84	22210691
462	Phosphorylation	AVELASTSRFELATR HHHHHCCCCHHHHCC	32.26	21712546
470	Phosphorylation	RFELATRTFPRITLV CHHHHCCCCCCEEEE	33.37	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CP26B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CP26B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CP26B_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of CP26B_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.