CP19A_HUMAN - dbPTM
CP19A_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CP19A_HUMAN
UniProt AC P11511
Protein Name Aromatase
Gene Name CYP19A1
Organism Homo sapiens (Human).
Sequence Length 503
Subcellular Localization Membrane
Peripheral membrane protein.
Protein Description Catalyzes the formation of aromatic C18 estrogens from C19 androgens..
Protein Sequence MVLEMLNPIHYNITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLISHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKLGLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLHPDETKNMLEMIFTPRNSDRCLEH
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
112PhosphorylationHIMKHNHYSSRFGSK
HHHHCCCCHHHHCHH		17.4122817900
118PhosphorylationHYSSRFGSKLGLQCI
CCHHHHCHHHCCEEE		23.23-
162PhosphorylationPGLVRMVTVCAESLK
CCHHHHHHHCHHHHH		10.6716964243
167PhosphorylationMVTVCAESLKTHLDR
HHHHCHHHHHHHHHH		19.35-
170PhosphorylationVCAESLKTHLDRLEE
HCHHHHHHHHHHHHH		32.7224043423
179PhosphorylationLDRLEEVTNESGYVD
HHHHHHHHCCCCHHH		36.2324043423
182PhosphorylationLEEVTNESGYVDVLT
HHHHHCCCCHHHHHH		37.1824043423
184PhosphorylationEVTNESGYVDVLTLL
HHHCCCCHHHHHHHH		11.6224043423
189PhosphorylationSGYVDVLTLLRRVML
CCHHHHHHHHHHHHH		24.4824043423
201PhosphorylationVMLDTSNTLFLRIPL
HHHCCCCCEEEEEEC		20.75-
220PhosphorylationIVVKIQGYFDAWQAL
EEEEEECCHHHHHHH		5.0619413330
241PhosphorylationFFKISWLYKKYEKSV
HHHHHHHHHHHHHHH		10.12-
361PhosphorylationKVMENFIYESMRYQP
HHHHHHHHHHHCCCH		9.6022817900
392PhosphorylationGYPVKKGTNIILNIG
CCCCCCCCEEEEEEC		31.9322817900
441PhosphorylationPRGCAGKYIAMVMMK
CCCCCHHHHHHHHHH		7.9322210691
484PhosphorylationLSLHPDETKNMLEMI
HCCCCHHCCCHHHHH		34.79-
497PhosphorylationMIFTPRNSDRCLEH-
HHCCCCCCCCCCCC-		27.93-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
361YPhosphorylationKinaseSRCP12931
PSP
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CP19A_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CP19A_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CD109_HUMANCD109physical
28514442
H2AX_HUMANH2AFXphysical
28514442
CA2D1_HUMANCACNA2D1physical
28514442
NPL4_HUMANNPLOC4physical
28514442
Drug and Disease Associations
Kegg Disease
H00599 46,XX disorders of sex development (Disorders related to androgen excess), including: Congenital adr
H00794 Aromatase excess syndrome
OMIM Disease
139300Aromatase excess syndrome (AEXS)
613546Aromatase deficiency (AROD)
Kegg Drug
D00153 Testolactone (USP/INN); Teslac (TN)
D00574 Aminoglutethimide (USP/INN); Cytadren (TN)
D00960 Anastrozole (JAN/USAN/INN); Arimidex (TN)
D00963 Exemestane (JAN/USP/INN); Aromasin (TN)
D00964 Letrozole (JAN/USP/INN); Femara (TN)
D02451 Fadrozole hydrochloride (USAN)
D03749 Plomestane (USAN/INN)
D03778 Fadrozole hydrochloride hydrate (JAN); Afema (TN)
D03781 Liarozole fumarate (USAN); Liazal (TN)
D03784 Liarozole hydrochloride (USAN)
D03786 Vorozole (USAN/INN); Rivizor (TN)
D07260 Formestane (INN); Lentaron (TN)
D07940 Fadrozole (INN)
DrugBank
DB00357Aminoglutethimide
DB01217Anastrozole
DB00443Betamethasone
DB04794Bifonazole
DB06719Buserelin
DB00389Carbimazole
DB00856Chlorphenesin
DB00882Clomifene
DB00257Clotrimazole
DB04839Cyproterone acetate
DB01406Danazol
DB01234Dexamethasone
DB00255Diethylstilbestrol
DB00917Dinoprostone
DB00858Drostanolone
DB01127Econazole
DB00974Edetic Acid
DB00292Etomidate
DB00990Exemestane
DB01026Ketoconazole
DB01006Letrozole
DB01227Levomethadyl Acetate
DB00367Levonorgestrel
DB00358Mefloquine
DB01065Melatonin
DB00333Methadone
DB06710Methyltestosterone
DB01110Miconazole
DB08804Nandrolone decanoate
DB00984Nandrolone phenpropionate
DB00184Nicotine
DB01229Paclitaxel
DB00481Raloxifene
DB06147Sulfathiazole
DB00675Tamoxifen
DB00857Terbinafine
DB00894Testolactone
DB00624Testosterone
DB01007Tioconazole
DB00072Trastuzumab
Regulatory Network of CP19A_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization.";
Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.;
Nat. Biotechnol. 24:1285-1292(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-162, AND MASSSPECTROMETRY.

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