CP100_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CP100_HUMAN
• UniProt AC: Q494V2
• Protein Name: Cilia- and flagella-associated protein 100 {ECO:0000305}
• Gene Name: CFAP100 {ECO:0000312|HGNC:HGNC:26842}
• Organism: Homo sapiens (Human).
• Sequence Length: 611
• Subcellular Localization: Cytoplasm, cytoskeleton, cilium axoneme .
• Protein Description: May play a role in ciliary/flagellar motility by regulating the assembly and the activity of axonemal inner dynein arm..
• Protein Sequence: MSEIPSTIVSKNMTNDKNSLESMNISSSSSTEENPKKQARKNEEHGPDPSANPFHLSGDVDFFLLRDQERNKALSERQQQKTMRVHQKMTYSSKVSAKHTSLRRQLQLEDKQEDLEARAEAEHQRAFRDYTTWKLTLTKEKNVEPENMSGYIKQKRQMFLLQYALDVKRREIQRLETLATKEEARLERAEKSLEKDAALFDEFVRENDCSSVQAMRAAEKETKAKIEKILEIRDLTTQIVNIKSEISRFEDTLKHYKVYKDFLYKLSPKEWLEEQEKKHSFLKKAKEVSEASKESSVNSTPGDKGPGIKGKASSMWAKEGQGTKKPWRFLQTMRLGRSPSYLSSPQQGSQPSESSGGDSRGSNSPIPPTQEDTDSDGEEPQLYFTEPQQLLDVFRELEEQNLSLIQNSQETEKTLEELSHTLKHTQIRMDREVNQLKQWVTTMMMSITKEEDTAAELELKARVFHFGEYKGDQQDKLLESLNCKVLDVYRHCTGTQQEANLGTVQMLTIIEHQLDELLENLEHVPQVKIEQAERAKEKERRIRLREEKLQMQKILQEEHLQRARARAQAEIKKKRGRTLVCRSRPPAHRIKQQSEHTLMDKEEEELLFFFT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSEIPSTIV ------CCCCCCCEE		-
6	Phosphorylation	--MSEIPSTIVSKNM --CCCCCCCEECCCC		-
7	Phosphorylation	-MSEIPSTIVSKNMT -CCCCCCCEECCCCC		-
10	Phosphorylation	EIPSTIVSKNMTNDK CCCCCEECCCCCCCC		-
11	Acetylation	IPSTIVSKNMTNDKN CCCCEECCCCCCCCC		12653579
17	Acetylation	SKNMTNDKNSLESMN CCCCCCCCCCHHHCC		12653587
22	Phosphorylation	NDKNSLESMNISSSS CCCCCHHHCCCCCCC		-
30	Phosphorylation	MNISSSSSTEENPKK CCCCCCCCCCCCHHH		-
31	Phosphorylation	NISSSSSTEENPKKQ CCCCCCCCCCCHHHH		-
90	Phosphorylation	MRVHQKMTYSSKVSA HHHHHHHHHHCHHHH		18187866
91	Phosphorylation	RVHQKMTYSSKVSAK HHHHHHHHHCHHHHH		18187866
92	Phosphorylation	VHQKMTYSSKVSAKH HHHHHHHHCHHHHHH		21888424
94	Acetylation	QKMTYSSKVSAKHTS HHHHHHCHHHHHHHH		30587535
130	Phosphorylation	HQRAFRDYTTWKLTL HHHHHHHHCEEEEEE		20068231
131	Phosphorylation	QRAFRDYTTWKLTLT HHHHHHHCEEEEEEE		20068231
132	Phosphorylation	RAFRDYTTWKLTLTK HHHHHHCEEEEEEEC		20068231
136	Phosphorylation	DYTTWKLTLTKEKNV HHCEEEEEEECCCCC		20068231
138	Phosphorylation	TTWKLTLTKEKNVEP CEEEEEEECCCCCCC		20068231
139	Ubiquitination	TWKLTLTKEKNVEPE EEEEEEECCCCCCCC		29967540
236	Phosphorylation	ILEIRDLTTQIVNIK HHHHHHHHHHHHHHH		-
237	Phosphorylation	LEIRDLTTQIVNIKS HHHHHHHHHHHHHHH		-
252	O-linked_Glycosylation	EISRFEDTLKHYKVY HHHCHHHHHHHHHHH		30379171
280	Phosphorylation	EEQEKKHSFLKKAKE HHHHHHHHHHHHHHH		24719451
292	Phosphorylation	AKEVSEASKESSVNS HHHHHHHHHHHCCCC		-
299	Phosphorylation	SKESSVNSTPGDKGP HHHHCCCCCCCCCCC		-
313	Phosphorylation	PGIKGKASSMWAKEG CCCCCCHHHCCCCCC		27134283
314	Phosphorylation	GIKGKASSMWAKEGQ CCCCCHHHCCCCCCC		27134283
325	Acetylation	KEGQGTKKPWRFLQT CCCCCCCCCHHHHHH		7482729
332	Phosphorylation	KPWRFLQTMRLGRSP CCHHHHHHHCCCCCH		24719451
338	Phosphorylation	QTMRLGRSPSYLSSP HHHCCCCCHHHHCCC		24275569
375	Phosphorylation	PTQEDTDSDGEEPQL CCCCCCCCCCCCCEE		24275569
441	Phosphorylation	NQLKQWVTTMMMSIT HHHHHHHHHHHHHCC		21406692
442	Phosphorylation	QLKQWVTTMMMSITK HHHHHHHHHHHHCCC		21406692
446	Phosphorylation	WVTTMMMSITKEEDT HHHHHHHHCCCCCCC		21406692
448	Phosphorylation	TTMMMSITKEEDTAA HHHHHHCCCCCCCHH		21406692
453	Phosphorylation	SITKEEDTAAELELK HCCCCCCCHHHHHHH		20068231
594	Phosphorylation	AHRIKQQSEHTLMDK HHHHCCCCCCCCCCH		30622161
597	Phosphorylation	IKQQSEHTLMDKEEE HCCCCCCCCCCHHHH		30622161

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CP100_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CP100_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CP100_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KDM1A_HUMAN	KDM1A	physical	23455924
SUV91_HUMAN	SUV39H1	physical	23455924
SUV92_HUMAN	SUV39H2	physical	23455924

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.