COX5A_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: COX5A_MOUSE
• UniProt AC: P12787
• Protein Name: Cytochrome c oxidase subunit 5A, mitochondrial
• Gene Name: Cox5a
• Organism: Mus musculus (Mouse).
• Sequence Length: 146
• Subcellular Localization: Mitochondrion inner membrane.
• Protein Description: This is the heme A-containing chain of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport..
• Protein Sequence: MLAAALRRCTAAAAARGLLHPASAPSPAAAVCSIRCYSHGSHETDEEFDARWVTYFNKPDIDAWELRKGMNTLVGYDLVPEPKIIDAALRACRRLNDFASAVRILEVVKDKAGPHKEIYPYVIQELRPTLNELGISTPEELGLDKV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
38	Phosphorylation	VCSIRCYSHGSHETD HHEEEEECCCCCCCC	25.62	21082442
41	Phosphorylation	IRCYSHGSHETDEEF EEEECCCCCCCCHHC	16.84	21082442
44	Phosphorylation	YSHGSHETDEEFDAR ECCCCCCCCHHCCHH	43.20	23608596
58	Acetylation	RWVTYFNKPDIDAWE HHHHHCCCCCCCHHH	33.88	23864654
58	Succinylation	RWVTYFNKPDIDAWE HHHHHCCCCCCCHHH	33.88	26388266
68	Ubiquitination	IDAWELRKGMNTLVG CCHHHHHCCCCCCCC	75.12	22790023
68	Acetylation	IDAWELRKGMNTLVG CCHHHHHCCCCCCCC	75.12	24062335
76	Phosphorylation	GMNTLVGYDLVPEPK CCCCCCCCCCCCCHH	9.91	25195567
83	Ubiquitination	YDLVPEPKIIDAALR CCCCCCHHHHHHHHH	51.11	-
83	Acetylation	YDLVPEPKIIDAALR CCCCCCHHHHHHHHH	51.11	23576753
83	Succinylation	YDLVPEPKIIDAALR CCCCCCHHHHHHHHH	51.11	24315375
100	O-linked_Glycosylation	RRLNDFASAVRILEV HHHHHHHHHHHHHHH	27.56	55411627
109	Acetylation	VRILEVVKDKAGPHK HHHHHHHHCCCCCCC	59.70	23576753
109	Ubiquitination	VRILEVVKDKAGPHK HHHHHHHHCCCCCCC	59.70	27667366
109	Succinylation	VRILEVVKDKAGPHK HHHHHHHHCCCCCCC	59.70	26388266
137	Phosphorylation	LNELGISTPEELGLD HHHHCCCCHHHHCCC	32.57	-
145	Acetylation	PEELGLDKV------ HHHHCCCCC------	55.69	23954790
145	Succinylation	PEELGLDKV------ HHHHCCCCC------	55.69	23806337

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of COX5A_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of COX5A_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of COX5A_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of COX5A_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.