COX41_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: COX41_RAT
• UniProt AC: P10888
• Protein Name: Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
• Gene Name: Cox4i1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 169
• Subcellular Localization: Mitochondrion inner membrane.
• Protein Description: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport..
• Protein Sequence: MLATRALSLIGKRAISTSVCLRAHGSVVKSEDYALPSYVDRRDYPLPDVAHVKLLSASQKALKEKEKADWSSLSRDEKVQLYRIQFNESFAEMNKGTNEWKTVVGLAMFFIGFTALVLIWEKSYVYGPIPHTFDRDWVAMQTKRMLDMKVNPIQGFSAKWDYNKNEWKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
26	Phosphorylation	VCLRAHGSVVKSEDY HHHHHCCCEECCCCC	17.55	23984901
29	Succinylation	RAHGSVVKSEDYALP HHCCCEECCCCCCCC	46.07	-
29	Acetylation	RAHGSVVKSEDYALP HHCCCEECCCCCCCC	46.07	22902405
29	Succinylation	RAHGSVVKSEDYALP HHCCCEECCCCCCCC	46.07	-
30	Phosphorylation	AHGSVVKSEDYALPS HCCCEECCCCCCCCC	24.88	23991683
33	Phosphorylation	SVVKSEDYALPSYVD CEECCCCCCCCCCCC	13.14	22673903
37	Phosphorylation	SEDYALPSYVDRRDY CCCCCCCCCCCCCCC	38.34	22673903
38	Phosphorylation	EDYALPSYVDRRDYP CCCCCCCCCCCCCCC	12.39	22673903
44	Phosphorylation	SYVDRRDYPLPDVAH CCCCCCCCCCCCHHH	12.59	30181290
53	Acetylation	LPDVAHVKLLSASQK CCCHHHHHHHHHHHH	33.57	22902405
56	Phosphorylation	VAHVKLLSASQKALK HHHHHHHHHHHHHHH	35.99	23991683
58	Phosphorylation	HVKLLSASQKALKEK HHHHHHHHHHHHHHH	28.92	22108457
60	Acetylation	KLLSASQKALKEKEK HHHHHHHHHHHHHHH	53.87	22902405
60	Succinylation	KLLSASQKALKEKEK HHHHHHHHHHHHHHH	53.87	-
60	Succinylation	KLLSASQKALKEKEK HHHHHHHHHHHHHHH	53.87	26843850
63	Acetylation	SASQKALKEKEKADW HHHHHHHHHHHHCCH	72.15	26302492
65	Acetylation	SQKALKEKEKADWSS HHHHHHHHHHCCHHH	64.03	22902405
67	Acetylation	KALKEKEKADWSSLS HHHHHHHHCCHHHCC	63.81	22902405
71	Phosphorylation	EKEKADWSSLSRDEK HHHHCCHHHCCHHHC	23.19	27097102
72	Phosphorylation	KEKADWSSLSRDEKV HHHCCHHHCCHHHCE	26.55	27097102
74	Phosphorylation	KADWSSLSRDEKVQL HCCHHHCCHHHCEEE	39.37	27097102
78	Acetylation	SSLSRDEKVQLYRIQ HHCCHHHCEEEEEEE	39.30	22902405
89	Phosphorylation	YRIQFNESFAEMNKG EEEEECHHHHHHCCC	30.75	27097102
95	Acetylation	ESFAEMNKGTNEWKT HHHHHHCCCCCHHHH	66.84	22902405
149	Acetylation	TKRMLDMKVNPIQGF HHHHHCCCCCCCCCC	38.23	22902405
157	Phosphorylation	VNPIQGFSAKWDYNK CCCCCCCCCCCCCCC	35.45	22673903
157	O-linked_Glycosylation	VNPIQGFSAKWDYNK CCCCCCCCCCCCCCC	35.45	27213235
159	Acetylation	PIQGFSAKWDYNKNE CCCCCCCCCCCCCCC	39.12	22902405
164	Acetylation	SAKWDYNKNEWKK-- CCCCCCCCCCCCC--	50.44	22902405
168	Acetylation	DYNKNEWKK------ CCCCCCCCC------	42.29	22902405

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of COX41_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of COX41_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of COX41_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of COX41_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.