COX41_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: COX41_MOUSE
• UniProt AC: P19783
• Protein Name: Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
• Gene Name: Cox4i1
• Organism: Mus musculus (Mouse).
• Sequence Length: 169
• Subcellular Localization: Mitochondrion inner membrane.
• Protein Description: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport..
• Protein Sequence: MLASRALSLIGKRAISTSVCLRAHGSVVKSEDYAFPTYADRRDYPLPDVAHVTMLSASQKALKEKEKADWSSLSRDEKVQLYRIQFNESFAEMNRGTNEWKTVVGMAMFFIGFTALVLIWEKSYVYGPIPHTFDRDWVAMQTKRMLDMKANPIQGFSAKWDYDKNEWKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Acetylation	RALSLIGKRAISTSV HHHHHHHHHHHHHHH	31.49	23576753
26	Phosphorylation	VCLRAHGSVVKSEDY HHHHHCCCEECCCCC	17.55	27742792
29	Acetylation	RAHGSVVKSEDYAFP HHCCCEECCCCCCCC	46.07	23576753
29	Ubiquitination	RAHGSVVKSEDYAFP HHCCCEECCCCCCCC	46.07	-
29	Succinylation	RAHGSVVKSEDYAFP HHCCCEECCCCCCCC	46.07	23806337
29	Malonylation	RAHGSVVKSEDYAFP HHCCCEECCCCCCCC	46.07	26320211
29	Succinylation	RAHGSVVKSEDYAFP HHCCCEECCCCCCCC	46.07	-
30	Phosphorylation	AHGSVVKSEDYAFPT HCCCEECCCCCCCCC	24.88	27742792
33	Phosphorylation	SVVKSEDYAFPTYAD CEECCCCCCCCCCCC	13.19	27742792
38	Phosphorylation	EDYAFPTYADRRDYP CCCCCCCCCCCCCCC	13.52	25195567
44	Nitration	TYADRRDYPLPDVAH CCCCCCCCCCCCHHH	12.59	-
53	Phosphorylation	LPDVAHVTMLSASQK CCCHHHHHHHCHHHH	11.52	26745281
56	Phosphorylation	VAHVTMLSASQKALK HHHHHHHCHHHHHHH	18.30	26745281
58	Phosphorylation	HVTMLSASQKALKEK HHHHHCHHHHHHHHH	28.92	27742792
60	Acetylation	TMLSASQKALKEKEK HHHCHHHHHHHHHHH	53.87	23576753
60	Succinylation	TMLSASQKALKEKEK HHHCHHHHHHHHHHH	53.87	-
60	Succinylation	TMLSASQKALKEKEK HHHCHHHHHHHHHHH	53.87	23806337
60	Ubiquitination	TMLSASQKALKEKEK HHHCHHHHHHHHHHH	53.87	-
60	Malonylation	TMLSASQKALKEKEK HHHCHHHHHHHHHHH	53.87	26320211
65	Acetylation	SQKALKEKEKADWSS HHHHHHHHHHCCHHH	64.03	23201123
65	Succinylation	SQKALKEKEKADWSS HHHHHHHHHHCCHHH	64.03	24315375
67	Malonylation	KALKEKEKADWSSLS HHHHHHHHCCHHHCC	63.81	26320211
67	Acetylation	KALKEKEKADWSSLS HHHHHHHHCCHHHCC	63.81	23576753
67	Succinylation	KALKEKEKADWSSLS HHHHHHHHCCHHHCC	63.81	26388266
71	Phosphorylation	EKEKADWSSLSRDEK HHHHCCHHHCCHHHC	23.19	28066266
72	Phosphorylation	KEKADWSSLSRDEKV HHHCCHHHCCHHHCE	26.55	23737553
74	Phosphorylation	KADWSSLSRDEKVQL HCCHHHCCHHHCEEE	39.37	28066266
78	Acetylation	SSLSRDEKVQLYRIQ HHCCHHHCEEEEEEE	39.30	23864654
89	Phosphorylation	YRIQFNESFAEMNRG EEEECCHHHHHHCCC	30.75	29899451
143	Acetylation	DWVAMQTKRMLDMKA HHHHHHHHHHHHCCC	20.93	15618251
149	Ubiquitination	TKRMLDMKANPIQGF HHHHHHCCCCCCCCC	44.68	-
149	Succinylation	TKRMLDMKANPIQGF HHHHHHCCCCCCCCC	44.68	26388266
157	Phosphorylation	ANPIQGFSAKWDYDK CCCCCCCCCCCCCCC	35.45	28542873
159	Acetylation	PIQGFSAKWDYDKNE CCCCCCCCCCCCCCC	39.12	23864654
159	Succinylation	PIQGFSAKWDYDKNE CCCCCCCCCCCCCCC	39.12	23954790
164	Acetylation	SAKWDYDKNEWKK-- CCCCCCCCCCCCC--	51.00	23864654
164	Succinylation	SAKWDYDKNEWKK-- CCCCCCCCCCCCC--	51.00	23954790
164	Malonylation	SAKWDYDKNEWKK-- CCCCCCCCCCCCC--	51.00	26320211
168	Acetylation	DYDKNEWKK------ CCCCCCCCC------	42.29	23201123
169	Acetylation	YDKNEWKK------- CCCCCCCC-------	67.65	7631989

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
58	S	Phosphorylation	Kinase	PKACA	P05132	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of COX41_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of COX41_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of COX41_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.