CORA1_HUMAN - dbPTM
CORA1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CORA1_HUMAN
UniProt AC Q8IZC6
Protein Name Collagen alpha-1(XXVII) chain
Gene Name COL27A1
Organism Homo sapiens (Human).
Sequence Length 1860
Subcellular Localization Secreted, extracellular space, extracellular matrix. Found on some small banded collagen fibrils and meshworks..
Protein Description Plays a role during the calcification of cartilage and the transition of cartilage to bone..
Protein Sequence MGAGSARGARGTAAAAAARGGGFLFSWILVSFACHLASTQGAPEDVDILQRLGLSWTKAGSPAPPGVIPFQSGFIFTQRARLQAPTGTVIPAALGTELALVLSLCSHRVNHAFLFAVRSQKRKLQLGLQFLPGKTVVHLGSRRSVAFDLDMHDGRWHHLALELRGRTVTLVTACGQRRVPVLLPFHRDPALDPGGSFLFGKMNPHAVQFEGALCQFSIYPVTQVAHNYCTHLRKQCGQADTYQSPLGPLFSQDSGRPFTFQSDLALLGLENLTTATPALGSLPAGRGPRGTVAPATPTKPQRTSPTNPHQHMAVGGPAQTPLLPAKLSASNALDPMLPASVGGSTRTPRPAAAQPSQKITATKIPKSLPTKPSAPSTSIVPIKSPHPTQKTAPSSFTKSALPTQKQVPPTSRPVPARVSRPAEKPIQRNPGMPRPPPPSTRPLPPTTSSSKKPIPTLARTEAKITSHASKPASARTSTHKPPPFTALSSSPAPTPGSTRSTRPPATMVPPTSGTSTPRTAPAVPTPGSAPTGSKKPIGSEASKKAGPKSSPRKPVPLRPGKAARDVPLSDLTTRPSPRQPQPSQQTTPALVLAPAQFLSSSPRPTSSGYSIFHLAGSTPFPLLMGPPGPKGDCGLPGPPGLPGLPGIPGARGPRGPPGPYGNPGLPGPPGAKGQKGDPGLSPGKAHDGAKGDMGLPGLSGNPGPPGRKGHKGYPGPAGHPGEQGQPGPEGSPGAKGYPGRQGLPGPVGDPGPKGSRGYIGLPGLFGLPGSDGERGLPGVPGKRGKMGMPGFPGVFGERGPPGLDGNPGELGLPGPPGVPGLIGDLGVLGPIGYPGPKGMKGLMGSVGEPGLKGDKGEQGVPGVSGDPGFQGDKGSQGLPGFPGARGKPGPLGKVGDKGSIGFPGPPGPEGFPGDIGPPGDNGPEGMKGKPGARGLPGPRGQLGPEGDEGPMGPPGAPGLEGQPGRKGFPGRPGLDGVKGEPGDPGRPGPVGEQGFMGFIGLVGEPGIVGEKGDRGMMGPPGVPGPKGSMGHPGMPGGMGTPGEPGPQGPPGSRGPPGMRGAKGRRGPRGPDGPAGEQGSRGLKGPPGPQGRPGRPGQQGVAGERGHLGSRGFPGIPGPSGPPGTKGLPGEPGPQGPQGPIGPPGEMGPKGPPGAVGEPGLPGEAGMKGDLGPLGTPGEQGLIGQRGEPGLEGDSGPMGPDGLKGDRGDPGPDGEHGEKGQEGLMGEDGPPGPPGVTGVRGPEGKSGKQGEKGRTGAKGAKGYQGQLGEMGVPGDPGPPGTPGPKGSRGSLGPTGAPGRMGAQGEPGLAGYDGHKGIVGPLGPPGPKGEKGEQGEDGKAEGPPGPPGDRGPVGDRGDRGEPGDPGYPGQEGVQGLRGKPGQQGQPGHPGPRGWPGPKGSKGAEGPKGKQGKAGAPGRRGVQGLQGLPGPRGVVGRQGLEGIAGPDGLPGRDGQAGQQGEQGDDGDPGPMGPAGKRGNPGVAGLPGAQGPPGFKGESGLPGQLGPPGKRGTEGRTGLPGNQGEPGSKGQPGDSGEMGFPGMAGLFGPKGPPGDIGFKGIQGPRGPPGLMGKEGIVGPLGILGPSGLPGPKGDKGSRGDWGLQGPRGPPGPRGRPGPPGPPGGPIQLQQDDLGAAFQTWMDTSGALRPESYSYPDRLVLDQGGEIFKTLHYLSNLIQSIKTPLGTKENPARVCRDLMDCEQKMVDGTYWVDPNLGCSSDTIEVSCNFTHGGQTCLKPITASKVEFAISRVQMNFLHLLSSEVTQHITIHCLNMTVWQEGTGQTPAKQAVRFRAWNGQIFEAGGQFRPEVSMDGCKVQDGRWHQTLFTFRTQDPQQLPIISVDNLPPASSGKQYRLEVGPACFL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
167PhosphorylationALELRGRTVTLVTAC
EEEECCCEEEEEEEC		22.2230242111
169PhosphorylationELRGRTVTLVTACGQ
EECCCEEEEEEECCC		18.2030242111
172PhosphorylationGRTVTLVTACGQRRV
CCEEEEEEECCCCCC		21.2430242111
182PhosphorylationGQRRVPVLLPFHRDP
CCCCCCEEEECCCCC		4.0417081983
271N-linked_GlycosylationLALLGLENLTTATPA
HHHHCCCCCCCCCCC		47.97UniProtKB CARBOHYD
395PhosphorylationTQKTAPSSFTKSALP
CCCCCCCCCCCCCCC		35.5624719451
419PhosphorylationRPVPARVSRPAEKPI
CCCCCCCCCCCCCCC		27.3025907765
456PhosphorylationSSKKPIPTLARTEAK
CCCCCCCCCCCCCEE		33.50-
460PhosphorylationPIPTLARTEAKITSH
CCCCCCCCCEEHHCC		34.39-
511PhosphorylationPATMVPPTSGTSTPR
CCEECCCCCCCCCCC		33.4522210691
528PhosphorylationPAVPTPGSAPTGSKK
CCCCCCCCCCCCCCC		32.0722210691
539PhosphorylationGSKKPIGSEASKKAG
CCCCCCCCHHHHHCC		30.61-
542PhosphorylationKPIGSEASKKAGPKS
CCCCCHHHHHCCCCC		30.55-
543MethylationPIGSEASKKAGPKSS
CCCCHHHHHCCCCCC		54.40-
544MethylationIGSEASKKAGPKSSP
CCCHHHHHCCCCCCC		56.96-
549PhosphorylationSKKAGPKSSPRKPVP
HHHCCCCCCCCCCCC		49.0223312004
550PhosphorylationKKAGPKSSPRKPVPL
HHCCCCCCCCCCCCC		34.5523312004
572O-linked_GlycosylationDVPLSDLTTRPSPRQ
CCCHHHCCCCCCCCC		26.25OGP
573O-linked_GlycosylationVPLSDLTTRPSPRQP
CCHHHCCCCCCCCCC		48.13OGP
576PhosphorylationSDLTTRPSPRQPQPS
HHCCCCCCCCCCCCC		29.4417081983
576O-linked_GlycosylationSDLTTRPSPRQPQPS
HHCCCCCCCCCCCCC		29.44OGP
586O-linked_GlycosylationQPQPSQQTTPALVLA
CCCCCCCCCCEEEEE		27.40OGP
681PhosphorylationQKGDPGLSPGKAHDG
CCCCCCCCCCCCCCC		37.2124719451
845PhosphorylationGMKGLMGSVGEPGLK
CCCCCCCCCCCCCCC		17.0022210691
8872-HydroxyisobutyrylationGFPGARGKPGPLGKV
CCCCCCCCCCCCCCC		41.05-
1028PhosphorylationGVPGPKGSMGHPGMP
CCCCCCCCCCCCCCC		27.9325954137
1040PhosphorylationGMPGGMGTPGEPGPQ
CCCCCCCCCCCCCCC		21.16-
1052PhosphorylationGPQGPPGSRGPPGMR
CCCCCCCCCCCCCCC		39.5825954137
1064MethylationGMRGAKGRRGPRGPD
CCCCCCCCCCCCCCC		39.41-
1286PhosphorylationGTPGPKGSRGSLGPT
CCCCCCCCCCCCCCC		39.3322210691
1289PhosphorylationGPKGSRGSLGPTGAP
CCCCCCCCCCCCCCC		29.1022210691
1474MethylationPMGPAGKRGNPGVAG
CCCCCCCCCCCCCCC		49.56-
1582PhosphorylationPLGILGPSGLPGPKG
CCEECCCCCCCCCCC		51.68-
1591AcetylationLPGPKGDKGSRGDWG
CCCCCCCCCCCCCCC		68.417661881
1678PhosphorylationNLIQSIKTPLGTKEN
HHHHHCCCCCCCCCC		23.2924719451
1705PhosphorylationQKMVDGTYWVDPNLG
HHCCCCCEEECCCCC		14.6824248375
1714PhosphorylationVDPNLGCSSDTIEVS
ECCCCCCCCCEEEEE		29.4724248375
1715PhosphorylationDPNLGCSSDTIEVSC
CCCCCCCCCEEEEEC		42.7324248375
1717PhosphorylationNLGCSSDTIEVSCNF
CCCCCCCEEEEECCC		22.4524248375
1769N-linked_GlycosylationHITIHCLNMTVWQEG
HEEEEEECEEEECCC		29.49UniProtKB CARBOHYD
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CORA1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CORA1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CORA1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of CORA1_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
615155Steel syndrome (STLS)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CORA1_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-419, AND MASSSPECTROMETRY.

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