COPB2_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: COPB2_RAT
• UniProt AC: O35142
• Protein Name: Coatomer subunit beta'
• Gene Name: Copb2
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 905
• Subcellular Localization: Cytoplasm, cytosol. Golgi apparatus membrane ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. The coatomer is cytoplasmic or polymerized on the cytopl
• Protein Description: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).; This coatomer complex protein, essential for Golgi budding and vesicular trafficking, is a selective binding protein (RACK) for protein kinase C, epsilon type. It binds to Golgi membranes in a GTP-dependent manner..
• Protein Sequence: MPLRLDIKRKLTAMSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFVARKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTPEGHAQNVSCATFHPELPIIITGSEDGTVRIWHSSTYRLESTLNYGMERVWCVASLRGSNNVALGYDEGSIIVKLGREEPAMSMDANGKIIWAKHSEVQQANLKAMGDTEIKDGERLPLAVKDMGSCEIYPQTIQHNPNGRFVVVCGDGEYIIYTAMALRNKSFGSAQEFAWAHDSSEYAIRESNSVVKIFKNFKEKKSFKPDFGAESIYGGFLLGVRSVNGLAFYDWENTELIRRIEIQPKHIFWSDSGELVCIATEESFFILKYLSEKVLAAQETHEGVTEDGIEDAFEVLGEIQEIVKTGLWVGDCFIYTSSVNRLNYYVGGEIVTIAHLDRTMYLLGYIPKDNRLYLGDKELNIVSYSLLVSVLEYQTAVMRRDFSMADKVLPTIPKEQRTRVAHFLEKQGFKQQALTVSTDPEHRFELALQLGELKIAYQLAVEAESEQKWKQLAELAISKCQFSLAQECLHHAQDYGGLLLLATASGNASMVNKLAEGAERDGKNNVAFMSYFLQGKLDACLELLIRTGRLPEAAFLARTYLPSQVSRVVKLWRENLSKVNQKAAESLADPTEYENLFPGLKEAFVVEEWVKETHADLWPAKQYPLVTPNEERNVMEEAKRFQPSRATAQQEPDGKPASSPVIMASQTTHKEEKSFQELEDDLDTMELEDIDTTDINLDEDILDD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Acetylation	MPLRLDIKRKLTAMS CCCCCHHHHHHHHCH	43.05	22902405
350	Phosphorylation	LAVKDMGSCEIYPQT EEEEECCCCEEECCE	11.26	27097102
354	Phosphorylation	DMGSCEIYPQTIQHN ECCCCEEECCEEEEC	2.72	27097102
408	Phosphorylation	SEYAIRESNSVVKIF CHHHHHHCCHHHHHC	25.26	22276854
413	Acetylation	RESNSVVKIFKNFKE HHCCHHHHHCCCCCC	40.02	22902405
416	Acetylation	NSVVKIFKNFKEKKS CHHHHHCCCCCCCCC	66.02	22902405
419	Acetylation	VKIFKNFKEKKSFKP HHHCCCCCCCCCCCC	77.38	22902405
608	Ubiquitination	RDFSMADKVLPTIPK CCCCCHHHCCCCCCH	35.81	-
627	Acetylation	RVAHFLEKQGFKQQA HHHHHHHHCCCCEEE	58.84	22902405
828	Phosphorylation	AKQYPLVTPNEERNV HHHCCCCCCCHHHHH	28.25	22108457
848	Phosphorylation	RFQPSRATAQQEPDG HHCCCCCCCCCCCCC	24.72	27097102
859	Phosphorylation	EPDGKPASSPVIMAS CCCCCCCCCCEEEEE	43.64	23712012
860	Phosphorylation	PDGKPASSPVIMASQ CCCCCCCCCEEEEEC	25.87	27097102
866	Phosphorylation	SSPVIMASQTTHKEE CCCEEEEECCCCCCH	15.64	27097102
868	Phosphorylation	PVIMASQTTHKEEKS CEEEEECCCCCCHHH	28.51	27097102
869	Phosphorylation	VIMASQTTHKEEKSF EEEEECCCCCCHHHH	24.26	27097102

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of COPB2_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of COPB2_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of COPB2_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of COPB2_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.