| UniProt ID | COE2_HUMAN | |
|---|---|---|
| UniProt AC | Q9HAK2 | |
| Protein Name | Transcription factor COE2 | |
| Gene Name | EBF2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 575 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Transcription factor that, in osteoblasts, activates the decoy receptor for RANKL, TNFRSF11B, which in turn regulates osteoclast differentiation. Acts in synergy with the Wnt-responsive LEF1/CTNNB1 pathway. Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3' (By similarity).. | |
| Protein Sequence | MFGIQDTLGRGPTLKEKSLGAEMDSVRSWVRNVGVVDANVAAQSGVALSRAHFEKQPPSNLRKSNFFHFVLALYDRQGQPVEIERTAFVDFVENDKEQGNEKTNNGTHYKLQLLYSNGVRTEQDLYVRLIDSVTKQPIAYEGQNKNPEMCRVLLTHEVMCSRCCEKKSCGNRNETPSDPVIIDRFFLKFFLKCNQNCLKTAGNPRDMRRFQVVLSTTVNVDGHVLAVSDNMFVHNNSKHGRRARRLDPSEATPCIKAISPSEGWTTGGAMVIIIGDNFFDGLQVVFGTMLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGAPGRFIYTALNEPTIDYGFQRLQKVIPRHPGDPERLAKEMLLKRAADLVEALYGTPHNNQDIILKRAADIAEALYSVPRNPSQLPALSSSPAHSGMMGINSYGSQLGVSISESTQGNNQGYIRNTSSISPRGYSSSSTPQQSNYSTSSNSMNGYSNVPMANLGVPGSPGFLNGSPTGSPYGIMSSSPTVGSSSTSSILPFSSSVFPAVKQKSAFAPVIRPQGSPSPACSSGNGNGFRAMTGLVVPPM | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 55 | Ubiquitination | LSRAHFEKQPPSNLR HHHHHHHCCCCCCCC | 68.13 | - | |
| 64 | Phosphorylation | PPSNLRKSNFFHFVL CCCCCCCCCHHHHHH | 32.22 | - | |
| 155 | Phosphorylation | EMCRVLLTHEVMCSR HHHHHHHCHHHHHHH | 16.30 | 30108239 | |
| 160 | S-palmitoylation | LLTHEVMCSRCCEKK HHCHHHHHHHHCCCC | 2.54 | 29575903 | |
| 161 | Phosphorylation | LTHEVMCSRCCEKKS HCHHHHHHHHCCCCC | 15.40 | 30108239 | |
| 321 | Ubiquitination | VEVTLSYKSKQFCKG EEEEEEECCHHHCCC | 48.04 | - | |
| 345 | Phosphorylation | LNEPTIDYGFQRLQK CCCCCCCHHHHHHHH | 18.91 | - | |
| 352 | Ubiquitination | YGFQRLQKVIPRHPG HHHHHHHHHCCCCCC | 46.88 | - | |
| 403 | Phosphorylation | ADIAEALYSVPRNPS HHHHHHHHCCCCCHH | 18.05 | 25884760 | |
| 404 | Phosphorylation | DIAEALYSVPRNPSQ HHHHHHHCCCCCHHH | 26.88 | 29978859 | |
| 457 | Phosphorylation | IRNTSSISPRGYSSS EECCCCCCCCCCCCC | 15.53 | 24961811 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of COE2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of COE2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of COE2_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of COE2_HUMAN !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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