COBA1_HUMAN - dbPTM
COBA1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID COBA1_HUMAN
UniProt AC P12107
Protein Name Collagen alpha-1(XI) chain
Gene Name COL11A1
Organism Homo sapiens (Human).
Sequence Length 1806
Subcellular Localization Secreted, extracellular space, extracellular matrix .
Protein Description May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils..
Protein Sequence MEPWSSRWKTKRWLWDFTVTTLALTFLFQAREVRGAAPVDVLKALDFHNSPEGISKTTGFCTNRKNSKGSDTAYRVSKQAQLSAPTKQLFPGGTFPEDFSILFTVKPKKGIQSFLLSIYNEHGIQQIGVEVGRSPVFLFEDHTGKPAPEDYPLFRTVNIADGKWHRVAISVEKKTVTMIVDCKKKTTKPLDRSERAIVDTNGITVFGTRILDEEVFEGDIQQFLITGDPKAAYDYCEHYSPDCDSSAPKAAQAQEPQIDEYAPEDIIEYDYEYGEAEYKEAESVTEGPTVTEETIAQTEANIVDDFQEYNYGTMESYQTEAPRHVSGTNEPNPVEEIFTEEYLTGEDYDSQRKNSEDTLYENKEIDGRDSDLLVDGDLGEYDFYEYKEYEDKPTSPPNEEFGPGVPAETDITETSINGHGAYGEKGQKGEPAVVEPGMLVEGPPGPAGPAGIMGPPGLQGPTGPPGDPGDRGPPGRPGLPGADGLPGPPGTMLMLPFRYGGDGSKGPTISAQEAQAQAILQQARIALRGPPGPMGLTGRPGPVGGPGSSGAKGESGDPGPQGPRGVQGPPGPTGKPGKRGRPGADGGRGMPGEPGAKGDRGFDGLPGLPGDKGHRGERGPQGPPGPPGDDGMRGEDGEIGPRGLPGEAGPRGLLGPRGTPGAPGQPGMAGVDGPPGPKGNMGPQGEPGPPGQQGNPGPQGLPGPQGPIGPPGEKGPQGKPGLAGLPGADGPPGHPGKEGQSGEKGALGPPGPQGPIGYPGPRGVKGADGVRGLKGSKGEKGEDGFPGFKGDMGLKGDRGEVGQIGPRGEDGPEGPKGRAGPTGDPGPSGQAGEKGKLGVPGLPGYPGRQGPKGSTGFPGFPGANGEKGARGVAGKPGPRGQRGPTGPRGSRGARGPTGKPGPKGTSGGDGPPGPPGERGPQGPQGPVGFPGPKGPPGPPGKDGLPGHPGQRGETGFQGKTGPPGPGGVVGPQGPTGETGPIGERGHPGPPGPPGEQGLPGAAGKEGAKGDPGPQGISGKDGPAGLRGFPGERGLPGAQGAPGLKGGEGPQGPPGPVGSPGERGSAGTAGPIGLPGRPGPQGPPGPAGEKGAPGEKGPQGPAGRDGVQGPVGLPGPAGPAGSPGEDGDKGEIGEPGQKGSKGDKGENGPPGPPGLQGPVGAPGIAGGDGEPGPRGQQGMFGQKGDEGARGFPGPPGPIGLQGLPGPPGEKGENGDVGPMGPPGPPGPRGPQGPNGADGPQGPPGSVGSVGGVGEKGEPGEAGNPGPPGEAGVGGPKGERGEKGEAGPPGAAGPPGAKGPPGDDGPKGNPGPVGFPGDPGPPGEPGPAGQDGVGGDKGEDGDPGQPGPPGPSGEAGPPGPPGKRGPPGAAGAEGRQGEKGAKGEAGAEGPPGKTGPVGPQGPAGKPGPEGLRGIPGPVGEQGLPGAAGQDGPPGPMGPPGLPGLKGDPGSKGEKGHPGLIGLIGPPGEQGEKGDRGLPGTQGSPGAKGDGGIPGPAGPLGPPGPPGLPGPQGPKGNKGSTGPAGQKGDSGLPGPPGSPGPPGEVIQPLPILSSKKTRRHTEGMQADADDNILDYSDGMEEIFGSLNSLKQDIEHMKFPMGTQTNPARTCKDLQLSHPDFPDGEYWIDPNQGCSGDSFKVYCNFTSGGETCIYPDKKSEGVRISSWPKEKPGSWFSEFKRGKLLSYLDVEGNSINMVQMTFLKLLTASARQNFTYHCHQSAAWYDVSSGSYDKALRFLGSNDEEMSYDNNPFIKTLYDGCASRKGYEKTVIEINTPKIDQVPIVDVMINDFGDQNQKFGFEVGPVCFLG
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
5Phosphorylation---MEPWSSRWKTKR
---CCCCHHHCCCCH		22.2729759185
6Phosphorylation--MEPWSSRWKTKRW
--CCCCHHHCCCCHH		37.9929759185
10PhosphorylationPWSSRWKTKRWLWDF
CCHHHCCCCHHHHHH		20.9129759185
57PhosphorylationSPEGISKTTGFCTNR
CCCCHHCCCCCCCCC		25.92-
58PhosphorylationPEGISKTTGFCTNRK
CCCHHCCCCCCCCCC		31.81-
62PhosphorylationSKTTGFCTNRKNSKG
HCCCCCCCCCCCCCC		35.48-
67PhosphorylationFCTNRKNSKGSDTAY
CCCCCCCCCCCCCHH		41.24-
70PhosphorylationNRKNSKGSDTAYRVS
CCCCCCCCCCHHHHC		35.21-
72PhosphorylationKNSKGSDTAYRVSKQ
CCCCCCCCHHHHCHH		27.56-
72O-linked_GlycosylationKNSKGSDTAYRVSKQ
CCCCCCCCHHHHCHH		27.5630620550
74PhosphorylationSKGSDTAYRVSKQAQ
CCCCCCHHHHCHHHC		17.40-
83PhosphorylationVSKQAQLSAPTKQLF
HCHHHCCCCCCCCCC		21.8128258704
100PhosphorylationGTFPEDFSILFTVKP
CCCCCCCEEEEEECC		30.6128258704
113PhosphorylationKPKKGIQSFLLSIYN
CCCCCHHHHHHHHHH		18.8822210691
117PhosphorylationGIQSFLLSIYNEHGI
CHHHHHHHHHHHCCC		25.7722210691
143PhosphorylationVFLFEDHTGKPAPED
EEEEECCCCCCCCCC		60.2622210691
193PhosphorylationTTKPLDRSERAIVDT
CCCCCCHHHCEEECC		30.97-
300 (in isoform 2)Phosphorylation-17.9022468782
303 (in isoform 2)Phosphorylation-6.0722468782
355PhosphorylationYDSQRKNSEDTLYEN
HHHCCCCCCCCCCCC		39.6327251275
358PhosphorylationQRKNSEDTLYENKEI
CCCCCCCCCCCCCCC		27.4727251275
386PhosphorylationGEYDFYEYKEYEDKP
CCCCEEECCCCCCCC		9.57-
508O-linked_GlycosylationGDGSKGPTISAQEAQ
CCCCCCCCCCHHHHH		35.91OGP
573PhosphorylationVQGPPGPTGKPGKRG
CCCCCCCCCCCCCCC		64.8527251275
612AllysineLPGLPGDKGHRGERG
CCCCCCCCCCCCCCC		63.63-
612DeaminationLPGLPGDKGHRGERG
CCCCCCCCCCCCCCC		63.633182841
776PhosphorylationGVRGLKGSKGEKGED
CCCCCCCCCCCCCCC		35.5830576142
875AcetylationGARGVAGKPGPRGQR
CCCCCCCCCCCCCCC		36.747669751
897PhosphorylationSRGARGPTGKPGPKG
CCCCCCCCCCCCCCC		61.7423532336
1121PhosphorylationGPAGPAGSPGEDGDK
CCCCCCCCCCCCCCC		31.6630576742
1380UbiquitinationRQGEKGAKGEAGAEG
CCCCCCCCCCCCCCC		66.99-
1452AllysineDPGSKGEKGHPGLIG
CCCCCCCCCCCCEEE		71.79-
1452DeaminationDPGSKGEKGHPGLIG
CCCCCCCCCCCCEEE		71.793182841
1640N-linked_GlycosylationDSFKVYCNFTSGGET
CCEEEEEEECCCCCE		26.08UniProtKB CARBOHYD
1682PhosphorylationFKRGKLLSYLDVEGN
HHCCCEEEEEECCCC		33.8020873877
1683PhosphorylationKRGKLLSYLDVEGNS
HCCCEEEEEECCCCC		13.5920873877
1690PhosphorylationYLDVEGNSINMVQMT
EEECCCCCEEHHHHH		26.6220873877
1697PhosphorylationSINMVQMTFLKLLTA
CEEHHHHHHHHHHHH		14.5520873877
1721PhosphorylationCHQSAAWYDVSSGSY
ECCCCCEEECCCCCH		11.18-
1752PhosphorylationDNNPFIKTLYDGCAS
CCCHHHHHHHHHHHH		26.2422210691
1754PhosphorylationNPFIKTLYDGCASRK
CHHHHHHHHHHHHCC		18.6022210691
1759PhosphorylationTLYDGCASRKGYEKT
HHHHHHHHCCCCEEE		38.3022210691
1766PhosphorylationSRKGYEKTVIEINTP
HCCCCEEEEEECCCC		18.12-
1772PhosphorylationKTVIEINTPKIDQVP
EEEEECCCCCCCCCC		31.46-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of COBA1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of COBA1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of COBA1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
FXL19_HUMANFBXL19physical
22660580
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
604841Stickler syndrome 2 (STL2)
154780Marshall syndrome (MRSHS)
228520Fibrochondrogenesis 1 (FBCG1)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of COBA1_HUMAN

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Related Literatures of Post-Translational Modification

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