CO1A2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CO1A2_MOUSE
• UniProt AC: Q01149
• Protein Name: Collagen alpha-2(I) chain
• Gene Name: Col1a2
• Organism: Mus musculus (Mouse).
• Sequence Length: 1372
• Subcellular Localization: Secreted, extracellular space, extracellular matrix .
• Protein Description: Type I collagen is a member of group I collagen (fibrillar forming collagen)..
• Protein Sequence: MLSFVDTRTLLLLAVTSCLATCQYLQSGSVRKGPTGDRGPRGQRGPAGPRGRDGVDGPMGPPGPPGSPGPPGSPAPPGLTGNFAAQYSDKGVSSGPGPMGLMGPRGPPGAVGAPGPQGFQGPAGEPGEPGQTGPAGPRGPAGSPGKAGEDGHPGKPGRPGERGVVGPQGARGFPGTPGLPGFKGVKGHSGMDGLKGQPGAQGVKGEPGAPGENGTPGQAGARGLPGERGRVGAPGPAGARGSDGSVGPVGPAGPIGSAGPPGFPGAPGPKGELGPVGNPGPAGPAGPRGEVGLPGLSGPVGPPGNPGTNGLTGAKGATGLPGVAGAPGLPGPRGIPGPAGAAGATGARGLVGEPGPAGSKGESGNKGEPGSVGAQGPPGPSGEEGKRGSPGEAGSAGPAGPPGLRGSPGSRGLPGADGRAGVMGPPGNRGSTGPAGIRGPNGDAGRPGEPGLMGPRGLPGSPGNVGPSGKEGPVGLPGIDGRPGPIGPAGPRGEAGNIGFPGPKGPSGDPGKPGERGHPGLAGARGAPGPDGNNGAQGPPGPQGVQGGKGEQGPAGPPGFQGLPGPSGTTGEVGKPGERGLPGEFGLPGPAGPRGERGTPGESGAAGPSGPIGSRGPSGAPGPDGNKGEAGAVGAPGSAGASGPGGLPGERGAAGIPGGKGEKGETGLRGDTGNTGRDGARGIPGAVGAPGPAGASGDRGEAGAAGPSGPAGPRGSPGERGEVGPAGPNGFAGPAGAAGQPGAKGEKGTKGPKGENGIVGPTGSVGAAGPSGPNGPPGPVGSRGDGGPPGMTGFPGAAGRTGPPGPSGIAGPPGPPGAAGKEGIRGPRGDQGPVGRTGETGASGPPGFVGEKGPSGEPGTAGAPGTAGPQGLLGAPGILGLPGSRGERGLPGIAGALGEPGPLGISGPPGARGPPGAVGSPGVNGAPGEAGRDGNPGSDGPPGRDGQPGHKGERGYPGSIGPTGAAGAPGPHGSVGPAGKHGNRGEPGPAGSVGPVGAVGPRGPSGPQGIRGDKGEPGDKGHRGLPGLKGYSGLQGLPGLAGLHGDQGAPGPVGPAGPRGPAGPSGPVGKDGRSGQPGPVGPAGVRGSQGSQGPAGPPGPPGPPGPPGVSGGGYDFGFEGDFYRADQPRSQPSLRPKDYEVDATLKSLNNQIETLLTPEGSRKNPARTCRDLRLSHPEWNSDYYWIDPNQGCTMDAIKVYCDFSTGETCIQAQPVNTPAKNSYSRAQANKHVWLGETINGGSQFEYNVEGVSSKEMATQLAFMRLLANRASQNITYHCKNSIAYLDEETGSLNKAVLLQGSNDVELVAEGNSRFTYSVLVDGCSKKTNEWGKTIIEYKTNKPSRLPFLDIAPLDIGGADQEFRVEVGPVCFK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23	Pyrrolidone_carboxylic_acid	TSCLATCQYLQSGSV HHHHHHHHHHHCCCC	37.30	-
67	Phosphorylation	GPPGPPGSPGPPGSP CCCCCCCCCCCCCCC	32.24	25777480
73	Phosphorylation	GSPGPPGSPAPPGLT CCCCCCCCCCCCCCC	24.54	25777480
80	Phosphorylation	SPAPPGLTGNFAAQY CCCCCCCCCCCEEEC	35.67	25777480
86	Pyrrolidone_carboxylic_acid	LTGNFAAQYSDKGVS CCCCCEEECCCCCCC	34.53	-
87	Phosphorylation	TGNFAAQYSDKGVSS CCCCEEECCCCCCCC	17.70	25777480
88	Phosphorylation	GNFAAQYSDKGVSSG CCCEEECCCCCCCCC	22.29	25777480
90	Allysine	FAAQYSDKGVSSGPG CEEECCCCCCCCCCC	56.10	-
90	Deamination	FAAQYSDKGVSSGPG CEEECCCCCCCCCCC	56.10	-
143	Phosphorylation	GPRGPAGSPGKAGED CCCCCCCCCCCCCCC	32.36	25338131
176	Phosphorylation	GARGFPGTPGLPGFK CCCCCCCCCCCCCCC	17.89	21454597
183	Hydroxylation	TPGLPGFKGVKGHSG CCCCCCCCCCCCCCC	69.57	-
183	O-linked_Glycosylation	TPGLPGFKGVKGHSG CCCCCCCCCCCCCCC	69.57	-
297	Phosphorylation	EVGLPGLSGPVGPPG CCCCCCCCCCCCCCC	47.14	22817900
312	Phosphorylation	NPGTNGLTGAKGATG CCCCCCCCCCCCCCC	36.17	22817900
359	Phosphorylation	GEPGPAGSKGESGNK CCCCCCCCCCCCCCC	39.32	27717184
363	Phosphorylation	PAGSKGESGNKGEPG CCCCCCCCCCCCCCC	57.23	27717184
371	Phosphorylation	GNKGEPGSVGAQGPP CCCCCCCCCCCCCCC	28.26	27717184
381	Phosphorylation	AQGPPGPSGEEGKRG CCCCCCCCCCCCCCC	65.83	26824392
407	Phosphorylation	GPPGLRGSPGSRGLP CCCCCCCCCCCCCCC	21.47	25338131
461	Phosphorylation	GPRGLPGSPGNVGPS CCCCCCCCCCCCCCC	27.91	29514104
599	Phosphorylation	GPRGERGTPGESGAA CCCCCCCCCCCCCCC	34.05	25367039
603	Phosphorylation	ERGTPGESGAAGPSG CCCCCCCCCCCCCCC	39.38	25367039
609	Phosphorylation	ESGAAGPSGPIGSRG CCCCCCCCCCCCCCC	57.17	25367039
614	Phosphorylation	GPSGPIGSRGPSGAP CCCCCCCCCCCCCCC	34.48	25367039
677	Methylation	GDTGNTGRDGARGIP CCCCCCCCCCCCCCC	36.83	-
1070	Acetylation	GPSGPVGKDGRSGQP CCCCCCCCCCCCCCC	58.19	23806337
1070	Succinylation	GPSGPVGKDGRSGQP CCCCCCCCCCCCCCC	58.19	23806337
1088	Phosphorylation	GPAGVRGSQGSQGPA CCCCCCCCCCCCCCC	22.32	25777480
1091	Phosphorylation	GVRGSQGSQGPAGPP CCCCCCCCCCCCCCC	25.07	25777480
1110	Phosphorylation	PPGPPGVSGGGYDFG CCCCCCCCCCCCCCC	37.32	25777480
1114	Phosphorylation	PGVSGGGYDFGFEGD CCCCCCCCCCCCCCC	16.04	25777480
1123	Phosphorylation	FGFEGDFYRADQPRS CCCCCCEEECCCCCC	15.05	25777480
1273	N-linked_Glycosylation	LANRASQNITYHCKN HHHHHHCCEEEECCC	26.52	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CO1A2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CO1A2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CO1A2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of CO1A2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.