CO040_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CO040_HUMAN
• UniProt AC: Q8WUR7
• Protein Name: UPF0235 protein C15orf40
• Gene Name: C15orf40
• Organism: Homo sapiens (Human).
• Sequence Length: 153
• Protein Sequence: MLRLRSGLRHLRATPNTRGSARLLCAEMPKKAGATTKGKSQSKEPERPLPPLGPVAVDPKGCVTIAIHAKPGSKQNAVTDLTAEAVNVAIAAPPSEGEANAELCRYLSKVLELRKSDVVLDKGGKSREKVVKLLASTTPEEILEKLKKEAKKT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	O-linked_Glycosylation	--MLRLRSGLRHLRA --CCCCCCCCCHHCC	32.13	30379171
14	O-linked_Glycosylation	GLRHLRATPNTRGSA CCCHHCCCCCCCHHH	63.11	30379171
14	Phosphorylation	GLRHLRATPNTRGSA CCCHHCCCCCCCHHH	63.11	25954137
17	O-linked_Glycosylation	HLRATPNTRGSARLL HHCCCCCCCHHHHHE	58.61	30379171
30	Acetylation	LLCAEMPKKAGATTK HEEECCCHHCCCCCC	15.31	25953088
35	Phosphorylation	MPKKAGATTKGKSQS CCHHCCCCCCCCCCC	2.81	20068231
36	Phosphorylation	PKKAGATTKGKSQSK CHHCCCCCCCCCCCC	6.22	20068231
40	Phosphorylation	GATTKGKSQSKEPER CCCCCCCCCCCCCCC	2.61	24719451
89	Phosphorylation	TAEAVNVAIAAPPSE HHHHHHEEEECCCCC	29.24	18669648
106	Phosphorylation	ANAELCRYLSKVLEL HHHHHHHHHHHHHHH	3.06	20068231
108	Phosphorylation	AELCRYLSKVLELRK HHHHHHHHHHHHHHH	18.44	20068231
109	Ubiquitination	ELCRYLSKVLELRKS HHHHHHHHHHHHHHH	32.55	21890473
116	Phosphorylation	KVLELRKSDVVLDKG HHHHHHHHCEEEECC	5.55	25159151
122	Ubiquitination	KSDVVLDKGGKSREK HHCEEEECCCCCHHH	65.22	24816145
132	Ubiquitination	KSREKVVKLLASTTP CCHHHHHHHHHCCCH		29967540
145	Ubiquitination	TPEEILEKLKKEAKK CHHHHHHHHHHHHHC		29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CO040_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CO040_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CO040_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of CO040_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-89, AND MASSSPECTROMETRY.
PubMed: 18669648