CNN3_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CNN3_RAT
• UniProt AC: P37397
• Protein Name: Calponin-3
• Gene Name: Cnn3
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 330
• Protein Description: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity..
• Protein Sequence: MTHFNKGPSYGLSAEVKNKIASKYDQQAEEDLRNWIEEVTGMGIGTNFQLGLKDGIILCELINKLQPGSVKKVNESSLNWPQLENIGNFIKAIQAYGMKPHDIFEANDLFENGNMTQVQTTLVALAGLAKTKGFHTTIDIGVKYAEKQTRRFDEGKLKAGQSVIGLQMGTNKCASQAGMTAYGTRRHLYDPKMQTDKPFDQTTISLQMGTNKGASQAGMSAPGTRRDIYDQKLTLQPVDNSTISLQMGTNKVASQKGMSVYGLGRQVYDPKYCAAPTEPVIHNGSQGTGTNGSEISDSDYQAEYPDEYHGEYPDEYPREYQYGDDQGIDY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Acetylation	--MTHFNKGPSYGLS --CCCCCCCCCCCCC	71.85	22902405
23	Acetylation	VKNKIASKYDQQAEE HHHHHHHHHHHHHHH	43.77	-
156	Acetylation	TRRFDEGKLKAGQSV CCCCCCCCCCCCCEE	44.78	22902405
158	Methylation	RFDEGKLKAGQSVIG CCCCCCCCCCCEEEE	54.69	-
162	Phosphorylation	GKLKAGQSVIGLQMG CCCCCCCEEEEEECC	18.13	23984901
175	Phosphorylation	MGTNKCASQAGMTAY CCCCHHHHHHCCCCC	29.99	22817900
180	Phosphorylation	CASQAGMTAYGTRRH HHHHHCCCCCCCCCC	18.79	27097102
182	Phosphorylation	SQAGMTAYGTRRHLY HHHCCCCCCCCCCCC	15.18	27097102
184	Phosphorylation	AGMTAYGTRRHLYDP HCCCCCCCCCCCCCC	16.32	27097102
197	Acetylation	DPKMQTDKPFDQTTI CCCCCCCCCCCCCEE	51.47	22902405
254	Phosphorylation	MGTNKVASQKGMSVY ECCCHHHCCCCCCEE	35.10	25575281
259	Phosphorylation	VASQKGMSVYGLGRQ HHCCCCCCEECCCCC	22.36	23984901
261	Phosphorylation	SQKGMSVYGLGRQVY CCCCCCEECCCCCCC	10.18	27097102
272	Phosphorylation	RQVYDPKYCAAPTEP CCCCCCCCCCCCCCC	7.84	22673903
277	Phosphorylation	PKYCAAPTEPVIHNG CCCCCCCCCCEEECC	48.47	22668510
285	Phosphorylation	EPVIHNGSQGTGTNG CCEEECCCCCCCCCC	30.65	22668510
288	Phosphorylation	IHNGSQGTGTNGSEI EECCCCCCCCCCCCC	32.94	22668510
290	Phosphorylation	NGSQGTGTNGSEISD CCCCCCCCCCCCCCC	35.92	22668510
293	Phosphorylation	QGTGTNGSEISDSDY CCCCCCCCCCCCCCC	33.55	21630457
296	Phosphorylation	GTNGSEISDSDYQAE CCCCCCCCCCCCCCC	27.32	21630457
298	Phosphorylation	NGSEISDSDYQAEYP CCCCCCCCCCCCCCC	31.28	22668510
300	Phosphorylation	SEISDSDYQAEYPDE CCCCCCCCCCCCCCC	17.36	22673903
304	Phosphorylation	DSDYQAEYPDEYHGE CCCCCCCCCCCCCCC	20.99	22673903
308	Phosphorylation	QAEYPDEYHGEYPDE CCCCCCCCCCCCCCC	23.62	22673903
312	Phosphorylation	PDEYHGEYPDEYPRE CCCCCCCCCCCCCCH	22.15	22673903
316	Phosphorylation	HGEYPDEYPREYQYG CCCCCCCCCCHHCCC	18.25	22673903

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
261	Y	Phosphorylation	Kinase	FYN	P06241	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CNN3_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CNN3_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MK03_RAT	Mapk3	physical	20181831
MK01_RAT	Mapk1	physical	20181831

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.