CNKR3_RAT - dbPTM
CNKR3_RAT - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CNKR3_RAT
UniProt AC Q5SGD7
Protein Name Connector enhancer of kinase suppressor of ras 3
Gene Name Cnksr3
Organism Rattus norvegicus (Rat).
Sequence Length 555
Subcellular Localization Cytoplasm . Apical cell membrane
Peripheral membrane protein .
Protein Description Involved in transepithelial sodium transport. Regulates aldosterone-induced and epithelial sodium channel (ENaC)-mediated sodium transport through regulation of ENaC cell surface expression. Acts as a scaffold protein coordinating the assembly of an ENaC-regulatory complex (ERC)..
Protein Sequence MEPVTKWSPKQVVDWTRGLDDCLQPYVHKFEREKIDGEQLLKISHQDLEELGVTRIGHQELVLEAVDLLCALNYGLETDNMKNLVLKLRASSHNLQNYISSRRKSPAYDGNTSRKPPNEFLTSVVELIGAAKALLAWLDRAPFTGITDLSVTKNKIIQLCLDLTTAVQKDCLVAEMEDKVLNVVKVLNGICDKMMHSTTDPVMSQCACLEEVHLPNVRPGEGLGMYIKSTYDGLHVITGTTENSPADRSQKIHAGDEVIQVNRQTVVGWQLKNLVKKLRENPTGVVLLLKKRPTGSFSFTPAPLKNLRWKPPLVQTSPPPTTTQSPESTMDASLKKEKPAILDLYIPPPPAVPYSPRDENVSFSYRGHTKSKQPLPGRKGSESPNSFLDQESQRRRFTITDSDQLPGYSVGTNILPIKMRGKTPSYGKPRPLSMPADGNWMGIVDPFAKPRGHGRKGEDALCRYFSNERITPIIEESASPVYRFSRPLTERHLVRGADYIRGSRCYINSDLHSSATIPFQEEGPKKKSASSSAKASSGEPSLLVSWLTRLKLLTH
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
8PhosphorylationMEPVTKWSPKQVVDW
CCCCCCCCHHHHHHC		24.6325575281
238PhosphorylationYDGLHVITGTTENSP
CCCEEEEEECCCCCC		27.6425403869
240PhosphorylationGLHVITGTTENSPAD
CEEEEEECCCCCCCC		23.4525403869
241PhosphorylationLHVITGTTENSPADR
EEEEEECCCCCCCCH		34.2225403869
244PhosphorylationITGTTENSPADRSQK
EEECCCCCCCCHHHC		18.4225403869
316PhosphorylationWKPPLVQTSPPPTTT
CCCCCEECCCCCCCC		35.4027097102
317PhosphorylationKPPLVQTSPPPTTTQ
CCCCEECCCCCCCCC		20.5127097102
321PhosphorylationVQTSPPPTTTQSPES
EECCCCCCCCCCCCH		48.5327097102
322PhosphorylationQTSPPPTTTQSPEST
ECCCCCCCCCCCCHH		28.7227097102
323PhosphorylationTSPPPTTTQSPESTM
CCCCCCCCCCCCHHH		29.5427097102
325PhosphorylationPPPTTTQSPESTMDA
CCCCCCCCCCHHHCH		28.6627097102
328PhosphorylationTTTQSPESTMDASLK
CCCCCCCHHHCHHHC		32.2027097102
329PhosphorylationTTQSPESTMDASLKK
CCCCCCHHHCHHHCC		19.8727097102
333PhosphorylationPESTMDASLKKEKPA
CCHHHCHHHCCCCCC		36.1427097102
354PhosphorylationPPPPAVPYSPRDENV
CCCCCCCCCCCCCCC		25.3922108457
355PhosphorylationPPPAVPYSPRDENVS
CCCCCCCCCCCCCCC		13.8522108457
381PhosphorylationPLPGRKGSESPNSFL
CCCCCCCCCCCCCCC		37.6328432305
383PhosphorylationPGRKGSESPNSFLDQ
CCCCCCCCCCCCCCH		30.9527097102
386PhosphorylationKGSESPNSFLDQESQ
CCCCCCCCCCCHHHH		30.4827097102
466PhosphorylationDALCRYFSNERITPI
HHHHHHHCCCCCCCH		28.9325532521
479PhosphorylationPIIEESASPVYRFSR
CHHHCCCCCCCCCCC		24.9522108457
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CNKR3_RAT !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CNKR3_RAT !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CNKR3_RAT !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of CNKR3_RAT !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CNKR3_RAT

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Related Literatures of Post-Translational Modification

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