CNKR2_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CNKR2_RAT
• UniProt AC: Q9Z1T4
• Protein Name: Connector enhancer of kinase suppressor of ras 2
• Gene Name: Cnksr2
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 1032
• Subcellular Localization: Cytoplasm. Membrane; Peripheral membrane protein.
• Protein Description: May function as an adapter protein or regulator of Ras signaling pathways, in synaptic junctions..
• Protein Sequence: MALIMEPVSKWSPSQVVDWMKGLDDCLQQYIKNFEREKISGDQLLRITHQELEDLGVSRIGHQELILEAVDLLCALNYGLETENLKTLSHKLNASAKNLQNFITGRRRSGHYDGRTSRKLPNDFLTSVVDLIGAAKSLLAWLDRSPFAAVTDYSVTRNNVIQLCLELTTIVQQDCTVYETENKILHVCKTLSGVCDHIISLSSDPLVSQSAHLEVIQLANIKPSEGLGMYIKSTYDGLHVITGTTENSPADRCKKIHAGDEVIQVNHQTVVGWQLKNLVNALREDPSGVILTLKKRPQSMLTSAPALLKNMRWKPLALQPLIPRSPTSSVATPSSTISTPTKRDSSALQDLYIPPPPAEPYIPRDEKGNLPCEDLRGHMVGKPVHKGSESPNSFLDQEYRKRFNIVEEDTVLYCYEYEKGRSSSQGRRESTPTYGKLRPISMPVEYNWVGDYEDPNKMKRDSRRENSLLRYMSNEKIAQEEYMFQRNSKKDTGKKSKKKGDKSTSPTHYSLLPSLQMDALRQDIMGTPVPETTLYHTFQQSSLQHKSKKKNKGAIAGKSKRRISCKDLGRGDCEGWLWKKKDAKSYFSQKWKKYWFVLKDASLYWYINEEDEKAEGFISLPEFKIDRASECRKKYAFKACHPKIKSFYFAAEHLDDMNRWLNRINMLTAGYAERERIKQEQDYWSESDKEEADTPSTPKQDSPPPPYDTYPRPPSMSCASPYVEAKHSRLSSTETSQSQSSHEEFRQEVTGSSAVSPIRKTASQRRSWQDLIETPLTSSGLHYLQTLPLEDSVFSDSAAISPEHRRQSTLPTQKCHLQDHYGPYPLAESERMQVLNGNGGKPRSFTLPRDSGFNHCCLNAPVSACDPQDDIQPPEVEEEEEEEEEEAAGENIGEKNENREEKLGDSLQDLYRALEEASLSPLGEHRISTKIEYKLSFIKRCNDPVMNEKLHRLRILKSTLKAREGEVAIIDKVLDNPDLTSKEFQQWKQMYLDLFLDICQNTTSNDPLSISSEVDVITSSLTHTHSYIETHV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	MEPVSKWSPSQVVDW CCCCCCCCHHHHHHH	20.57	-
14	Phosphorylation	PVSKWSPSQVVDWMK CCCCCCHHHHHHHHH	30.05	-
32	Ubiquitination	DCLQQYIKNFEREKI HHHHHHHHHCHHHHC	51.13	-
91	Ubiquitination	NLKTLSHKLNASAKN CHHHHHHHHCHHHHH	39.81	-
242	Phosphorylation	YDGLHVITGTTENSP CCCEEEEEECCCCCH	27.64	25403869
244	Phosphorylation	GLHVITGTTENSPAD CEEEEEECCCCCHHH	23.45	25403869
245	Phosphorylation	LHVITGTTENSPADR EEEEEECCCCCHHHH	34.22	25403869
248	Phosphorylation	ITGTTENSPADRCKK EEECCCCCHHHHHCC	18.42	25403869
325	Phosphorylation	LQPLIPRSPTSSVAT EECCCCCCCCCCCCC	27.46	27097102
327	Phosphorylation	PLIPRSPTSSVATPS CCCCCCCCCCCCCCC	34.58	27097102
328	Phosphorylation	LIPRSPTSSVATPSS CCCCCCCCCCCCCCC	26.63	27097102
329	Phosphorylation	IPRSPTSSVATPSST CCCCCCCCCCCCCCC	20.46	27097102
332	Phosphorylation	SPTSSVATPSSTIST CCCCCCCCCCCCCCC	22.88	27097102
334	Phosphorylation	TSSVATPSSTISTPT CCCCCCCCCCCCCCC	35.44	27097102
335	Phosphorylation	SSVATPSSTISTPTK CCCCCCCCCCCCCCC	30.85	27097102
336	Phosphorylation	SVATPSSTISTPTKR CCCCCCCCCCCCCCC	24.24	27097102
338	Phosphorylation	ATPSSTISTPTKRDS CCCCCCCCCCCCCCC	28.55	27097102
339	Phosphorylation	TPSSTISTPTKRDSS CCCCCCCCCCCCCCC	31.00	27097102
341	Phosphorylation	SSTISTPTKRDSSAL CCCCCCCCCCCCCCH	38.51	27097102
342	Ubiquitination	STISTPTKRDSSALQ CCCCCCCCCCCCCHH	56.25	-
352	Phosphorylation	SSALQDLYIPPPPAE CCCHHHCCCCCCCCC	21.48	-
367	Ubiquitination	PYIPRDEKGNLPCED CCCCCCCCCCCCHHH	58.34	-
388	Phosphorylation	GKPVHKGSESPNSFL CCCCCCCCCCCCCCC	39.44	27097102
390	Phosphorylation	PVHKGSESPNSFLDQ CCCCCCCCCCCCCCH	30.95	30411139
393	Phosphorylation	KGSESPNSFLDQEYR CCCCCCCCCCCHHHH	30.48	27097102
430	Phosphorylation	SSQGRRESTPTYGKL CCCCCCCCCCCCCCC	37.56	25403869
441	Phosphorylation	YGKLRPISMPVEYNW CCCCCCCCCCEEECC	21.51	-
446	Phosphorylation	PISMPVEYNWVGDYE CCCCCEEECCCCCCC	17.98	-
452	Phosphorylation	EYNWVGDYEDPNKMK EECCCCCCCCCCCCC	19.12	-
482	Phosphorylation	EKIAQEEYMFQRNSK HHHHHHHHHHHHCCC	11.50	-
503	Phosphorylation	SKKKGDKSTSPTHYS CCCCCCCCCCCCHHH	38.57	22673903
504	Phosphorylation	KKKGDKSTSPTHYSL CCCCCCCCCCCHHHH	44.45	22673903
505	Phosphorylation	KKGDKSTSPTHYSLL CCCCCCCCCCHHHHC	34.59	22673903
507	Phosphorylation	GDKSTSPTHYSLLPS CCCCCCCCHHHHCHH	32.96	22673903
509	Phosphorylation	KSTSPTHYSLLPSLQ CCCCCCHHHHCHHHC	11.95	22673903
510	Phosphorylation	STSPTHYSLLPSLQM CCCCCHHHHCHHHCH	18.80	22673903
668	Phosphorylation	LNRINMLTAGYAERE HHHHHHHHHHHHHHH	13.78	-
671	Phosphorylation	INMLTAGYAERERIK HHHHHHHHHHHHHHH	11.65	-
683	Phosphorylation	RIKQEQDYWSESDKE HHHHHHHHCCHHHHC	15.55	-
685	Phosphorylation	KQEQDYWSESDKEEA HHHHHHCCHHHHCCC	22.46	22673903
687	Phosphorylation	EQDYWSESDKEEADT HHHHCCHHHHCCCCC	48.76	22673903
732	Phosphorylation	AKHSRLSSTETSQSQ HHHHHCCCCCCCCCC	34.55	30240740
752	Phosphorylation	FRQEVTGSSAVSPIR HHHHHHCCCCCCCHH	13.03	25403869
753	Phosphorylation	RQEVTGSSAVSPIRK HHHHHCCCCCCCHHH	33.75	25403869
756	Phosphorylation	VTGSSAVSPIRKTAS HHCCCCCCCHHHCHH	17.83	30240740
767	Phosphorylation	KTASQRRSWQDLIET HCHHHCCCHHHHHHC	31.14	22673903
774	Phosphorylation	SWQDLIETPLTSSGL CHHHHHHCCCCCCCC	19.32	22673903
777	Phosphorylation	DLIETPLTSSGLHYL HHHHCCCCCCCCCEE	23.27	22673903
778	Phosphorylation	LIETPLTSSGLHYLQ HHHCCCCCCCCCEEE	30.05	22673903
779	Phosphorylation	IETPLTSSGLHYLQT HHCCCCCCCCCEEEE	39.89	22673903
783	Phosphorylation	LTSSGLHYLQTLPLE CCCCCCCEEEECCCC	12.92	22673903
786	Phosphorylation	SGLHYLQTLPLEDSV CCCCEEEECCCCCCC	27.96	22673903
792	Phosphorylation	QTLPLEDSVFSDSAA EECCCCCCCCCCCCC	18.71	22673903
795	Phosphorylation	PLEDSVFSDSAAISP CCCCCCCCCCCCCCH	28.62	22673903
797	Phosphorylation	EDSVFSDSAAISPEH CCCCCCCCCCCCHHH	20.57	22673903
801	Phosphorylation	FSDSAAISPEHRRQS CCCCCCCCHHHHHHC	21.36	22673903
808	Phosphorylation	SPEHRRQSTLPTQKC CHHHHHHCCCCCCCC	30.05	25403869
809	Phosphorylation	PEHRRQSTLPTQKCH HHHHHHCCCCCCCCC	28.55	25403869
821	Phosphorylation	KCHLQDHYGPYPLAE CCCCCCCCCCCCCCH	28.25	-
906	Phosphorylation	REEKLGDSLQDLYRA HHHHHHHHHHHHHHH	26.57	30411139
911	Phosphorylation	GDSLQDLYRALEEAS HHHHHHHHHHHHHHC	11.35	-
982	Ubiquitination	DNPDLTSKEFQQWKQ CCCCCCHHHHHHHHH	58.26	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CNKR2_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CNKR2_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CNKR2_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of CNKR2_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.