CLYBL_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CLYBL_HUMAN
• UniProt AC: Q8N0X4
• Protein Name: Citramalyl-CoA lyase, mitochondrial {ECO:0000303|PubMed:29056341}
• Gene Name: CLYBL {ECO:0000312|HGNC:HGNC:18355}
• Organism: Homo sapiens (Human).
• Sequence Length: 340
• Subcellular Localization: Mitochondrion .
• Protein Description: Mitochondrial citramalyl-CoA lyase indirectly involved in the vitamin B12 metabolism. [PubMed: 29056341 Converts citramalyl-CoA into acetyl-CoA and pyruvate in the C5-dicarboxylate catabolism pathway]
• Protein Sequence: MALRLLRRAARGAAAAALLRLKASLAADIPRLGYSSSSHHKYIPRRAVLYVPGNDEKKIKKIPSLNVDCAVLDCEDGVAANKKNEARLRIVKTLEDIDLGPTEKCVRVNSVSSGLAEEDLETLLQSRVLPSSLMLPKVESPEEIQWFADKFSFHLKGRKLEQPMNLIPFVETAMGLLNFKAVCEETLKVGPQVGLFLDAVVFGGEDFRASIGATSSKETLDILYARQKIVVIAKAFGLQAIDLVYIDFRDGAGLLRQSREGAAMGFTGKQVIHPNQIAVVQEQFSPSPEKIKWAEELIAAFKEHQQLGKGAFTFQGSMIDMPLLKQAQNTVTLATSIKEK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
57	Acetylation	YVPGNDEKKIKKIPS ECCCCCHHHHCCCCC	63.76	23236377
57	Succinylation	YVPGNDEKKIKKIPS ECCCCCHHHHCCCCC	63.76	23954790
58	Acetylation	VPGNDEKKIKKIPSL CCCCCHHHHCCCCCC	58.68	6271597
61	Acetylation	NDEKKIKKIPSLNVD CCHHHHCCCCCCCCC	64.42	-
82	Acetylation	EDGVAANKKNEARLR CCCCCCCCCCHHHHE	52.85	2402221
82	Succinylation	EDGVAANKKNEARLR CCCCCCCCCCHHHHE	52.85	-
82	Succinylation	EDGVAANKKNEARLR CCCCCCCCCCHHHHE	52.85	-
92	Acetylation	EARLRIVKTLEDIDL HHHHEEEEEHHHCCC	45.05	-
92	Succinylation	EARLRIVKTLEDIDL HHHHEEEEEHHHCCC	45.05	-
92	Succinylation	EARLRIVKTLEDIDL HHHHEEEEEHHHCCC	45.05	-
110	Phosphorylation	EKCVRVNSVSSGLAE CCCEEHHCCCCCCCH	22.11	28857561
112	Phosphorylation	CVRVNSVSSGLAEED CEEHHCCCCCCCHHH	20.64	28857561
113	Phosphorylation	VRVNSVSSGLAEEDL EEHHCCCCCCCHHHH	35.35	28857561
131	Phosphorylation	LQSRVLPSSLMLPKV HHCCCCCHHCCCCCC	31.76	-
132	Phosphorylation	QSRVLPSSLMLPKVE HCCCCCHHCCCCCCC	18.83	-
156	Acetylation	DKFSFHLKGRKLEQP HHHCHHCCCCCCCCC	48.37	30584815
159	Acetylation	SFHLKGRKLEQPMNL CHHCCCCCCCCCCCH	66.11	7304073
224	Phosphorylation	KETLDILYARQKIVV HHHHHHHHHHHHHHH	10.48	-
258	Phosphorylation	GAGLLRQSREGAAMG CCCHHHHCCCCCCCC	26.35	-
309	Succinylation	KEHQQLGKGAFTFQG HHHHHHCCCCEEECC	56.51	-
309	Succinylation	KEHQQLGKGAFTFQG HHHHHHCCCCEEECC	56.51	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CLYBL_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CLYBL_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CLYBL_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of CLYBL_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.