dbPTM

CLMN_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CLMN_HUMAN
UniProt AC	Q96JQ2
Protein Name	Calmin
Gene Name	CLMN
Organism	Homo sapiens (Human).
Sequence Length	1002
Subcellular Localization	Membrane Single-pass type IV membrane protein .
Protein Description
Protein Sequence	MAAHEWDWFQREELIGQISDIRVQNLQVERENVQKRTFTRWINLHLEKCNPPLEVKDLFVDIQDGKILMALLEVLSGRNLLHEYKSSSHRIFRLNNIAKALKFLEDSNVKLVSIDAAEIADGNPSLVLGLIWNIILFFQIKELTGNLSRNSPSSSLSPGSGGTDSDSSFPPTPTAERSVAISVKDQRKAIKALLAWVQRKTRKYGVAVQDFAGSWRSGLAFLAVIKAIDPSLVDMKQALENSTRENLEKAFSIAQDALHIPRLLEPEDIMVDTPDEQSIMTYVAQFLERFPELEAEDIFDSDKEVPIESTFVRIKETPSEQESKVFVLTENGERTYTVNHETSHPPPSKVFVCDKPESMKEFRLDGVSSHALSDSSTEFMHQIIDQVLQGGPGKTSDISEPSPESSILSSRKENGRSNSLPIKKTVHFEADTYKDPFCSKNLSLCFEGSPRVAKESLRQDGHVLAVEVAEEKEQKQESSKIPESSSDKVAGDIFLVEGTNNNSQSSSCNGALESTARHDEESHSLSPPGENTVMADSFQIKVNLMTVEALEEGDYFEAIPLKASKFNSDLIDFASTSQAFNKVPSPHETKPDEDAEAFENHAEKLGKRSIKSAHKKKDSPEPQVKMDKHEPHQDSGEEAEGCPSAPEETPVDKKPEVHEKAKRKSTRPHYEEEGEDDDLQGVGEELSSSPPSSCVSLETLGSHSEEGLDFKPSPPLSKVSVIPHDLFYFPHYEVPLAAVLEAYVEDPEDLKNEEMDLEEPEGYMPDLDSREEEADGSQSSSSSSVPGESLPSASDQVLYLSRGGVGTTPASEPAPLAPHEDHQQRETKENDPMDSHQSQESPNLENIANPLEENVTKESISSKKKEKRKHVDHVESSLFVAPGSVQSSDDLEEDSSDYSIPSRTSHSDSSIYLRRHTHRSSESDHFSYVQLRNAADLDDRRNRILTRKANSSGEAMSLGSHSPQSDSLTQLVQQPDMMYFILFLWLLVYCLLLFPQLDVSRL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
19	Phosphorylation	EELIGQISDIRVQNL HHHHHHHHHEEEEEC	21.06	24719451
76	Phosphorylation	MALLEVLSGRNLLHE HHHHHHHCCCCHHHH	40.66	24719451
86	Phosphorylation	NLLHEYKSSSHRIFR CHHHHHHCCCCHHHH	35.85	-
144	Phosphorylation	FFQIKELTGNLSRNS HHCHHHHHCCCCCCC	25.72	30624053
148	Phosphorylation	KELTGNLSRNSPSSS HHHHCCCCCCCCCCC	33.15	30624053
151	Phosphorylation	TGNLSRNSPSSSLSP HCCCCCCCCCCCCCC	25.67	26657352
153	Phosphorylation	NLSRNSPSSSLSPGS CCCCCCCCCCCCCCC	32.17	30278072
154	Phosphorylation	LSRNSPSSSLSPGSG CCCCCCCCCCCCCCC	38.39	30278072
155	Phosphorylation	SRNSPSSSLSPGSGG CCCCCCCCCCCCCCC	36.88	29116813
157	Phosphorylation	NSPSSSLSPGSGGTD CCCCCCCCCCCCCCC	29.21	30278072
160	Phosphorylation	SSSLSPGSGGTDSDS CCCCCCCCCCCCCCC	37.12	30278072
163	Phosphorylation	LSPGSGGTDSDSSFP CCCCCCCCCCCCCCC	35.54	30278072
165	Phosphorylation	PGSGGTDSDSSFPPT CCCCCCCCCCCCCCC	38.95	30278072
167	Phosphorylation	SGGTDSDSSFPPTPT CCCCCCCCCCCCCCC	37.52	30278072
168	Phosphorylation	GGTDSDSSFPPTPTA CCCCCCCCCCCCCCC	46.92	30278072
172	Phosphorylation	SDSSFPPTPTAERSV CCCCCCCCCCCCCEE	33.25	27251275
231	Phosphorylation	VIKAIDPSLVDMKQA HHHHHCHHHHCHHHH	36.96	30622161
301	Phosphorylation	EAEDIFDSDKEVPIE CHHHCCCCCCCCCCE	39.57	30278072
309	Phosphorylation	DKEVPIESTFVRIKE CCCCCCEEEEEEEEC	28.06	27732954
310	Phosphorylation	KEVPIESTFVRIKET CCCCCEEEEEEEECC	17.23	27732954
317	Phosphorylation	TFVRIKETPSEQESK EEEEEECCCCCCCCC	27.41	25693802
319	Phosphorylation	VRIKETPSEQESKVF EEEECCCCCCCCCEE	60.37	30622161
323	Phosphorylation	ETPSEQESKVFVLTE CCCCCCCCCEEEEEE	33.54	30622161
335	Phosphorylation	LTENGERTYTVNHET EEECCEEEEEECCCC	21.17	26503514
336	Phosphorylation	TENGERTYTVNHETS EECCEEEEEECCCCC	18.21	22468782
337	Phosphorylation	ENGERTYTVNHETSH ECCEEEEEECCCCCC	17.77	22468782
342	Phosphorylation	TYTVNHETSHPPPSK EEEECCCCCCCCCCC	25.45	22468782
343	Phosphorylation	YTVNHETSHPPPSKV EEECCCCCCCCCCCE	30.89	26503514
348	Phosphorylation	ETSHPPPSKVFVCDK CCCCCCCCCEEEECC	47.42	26503514
358	Phosphorylation	FVCDKPESMKEFRLD EEECCCHHHCEEECC	43.62	30622161
368	Phosphorylation	EFRLDGVSSHALSDS EEECCCCCCCCCCCC	23.18	25693802
369	Phosphorylation	FRLDGVSSHALSDSS EECCCCCCCCCCCCC	15.46	25693802
373	Phosphorylation	GVSSHALSDSSTEFM CCCCCCCCCCCHHHH	35.91	25693802
375	Phosphorylation	SSHALSDSSTEFMHQ CCCCCCCCCHHHHHH	35.47	25693802
376	Phosphorylation	SHALSDSSTEFMHQI CCCCCCCCHHHHHHH	36.63	25693802
377	Phosphorylation	HALSDSSTEFMHQII CCCCCCCHHHHHHHH	36.87	25693802
395	Phosphorylation	LQGGPGKTSDISEPS HHCCCCCCCCCCCCC	37.23	21082442
399	Phosphorylation	PGKTSDISEPSPESS CCCCCCCCCCCCCCC	48.74	29396449
402	Phosphorylation	TSDISEPSPESSILS CCCCCCCCCCCCCCC	36.93	30278072
405	Phosphorylation	ISEPSPESSILSSRK CCCCCCCCCCCCCCC	26.51	30243723
406	Phosphorylation	SEPSPESSILSSRKE CCCCCCCCCCCCCCC	26.36	30243723
409	Phosphorylation	SPESSILSSRKENGR CCCCCCCCCCCCCCC	26.82	29396449
410	Phosphorylation	PESSILSSRKENGRS CCCCCCCCCCCCCCC	43.88	29396449
417	Phosphorylation	SRKENGRSNSLPIKK CCCCCCCCCCCCCCE	31.97	23927012
419	Phosphorylation	KENGRSNSLPIKKTV CCCCCCCCCCCCEEE	36.45	23927012
433	Phosphorylation	VHFEADTYKDPFCSK EEEEECCCCCCCCCC	17.59	27642862
443	Phosphorylation	PFCSKNLSLCFEGSP CCCCCCCEEEECCCH	32.27	29396449
449	Phosphorylation	LSLCFEGSPRVAKES CEEEECCCHHHHHHH	11.44	30266825
522	Phosphorylation	TARHDEESHSLSPPG HCCCCHHHCCCCCCC	19.14	30108239
524	Phosphorylation	RHDEESHSLSPPGEN CCCHHHCCCCCCCCC	39.56	30108239
526	Phosphorylation	DEESHSLSPPGENTV CHHHCCCCCCCCCCE	31.87	25693802
532	Phosphorylation	LSPPGENTVMADSFQ CCCCCCCCEECCCEE	13.83	28985074
555	Phosphorylation	EALEEGDYFEAIPLK HHHHCCCCEEEEECC	17.74	25106551
564	Phosphorylation	EAIPLKASKFNSDLI EEEECCCHHCCCCCC	35.87	-
565	Methylation	AIPLKASKFNSDLID EEECCCHHCCCCCCH	54.12	-
568	Phosphorylation	LKASKFNSDLIDFAS CCCHHCCCCCCHHHH	36.61	25693802
575	Phosphorylation	SDLIDFASTSQAFNK CCCCHHHHHHHHHHC	28.69	23898821
576	Phosphorylation	DLIDFASTSQAFNKV CCCHHHHHHHHHHCC	22.79	28348404
577	Phosphorylation	LIDFASTSQAFNKVP CCHHHHHHHHHHCCC	19.60	28348404
585	Phosphorylation	QAFNKVPSPHETKPD HHHHCCCCCCCCCCH	41.71	29255136
589	Phosphorylation	KVPSPHETKPDEDAE CCCCCCCCCCHHHHH	44.86	29255136
619	Phosphorylation	SAHKKKDSPEPQVKM HHHCCCCCCCCCCCC	39.79	29255136
635	Phosphorylation	KHEPHQDSGEEAEGC CCCCCCCCCCCCCCC	41.35	29255136
644	Phosphorylation	EEAEGCPSAPEETPV CCCCCCCCCCCCCCC	61.61	25849741
649	Phosphorylation	CPSAPEETPVDKKPE CCCCCCCCCCCCCHH	27.27	23927012
688	Phosphorylation	GVGEELSSSPPSSCV CHHHHHHCCCCCCCE	60.53	24275569
696	Phosphorylation	SPPSSCVSLETLGSH CCCCCCEEEECCCCC	25.47	24275569
699	Phosphorylation	SSCVSLETLGSHSEE CCCEEEECCCCCCCC	41.53	24275569
702	Phosphorylation	VSLETLGSHSEEGLD EEEECCCCCCCCCCC	27.27	24275569
704	Phosphorylation	LETLGSHSEEGLDFK EECCCCCCCCCCCCC	38.75	24275569
713	Phosphorylation	EGLDFKPSPPLSKVS CCCCCCCCCCCHHEE	39.48	26074081
717	Phosphorylation	FKPSPPLSKVSVIPH CCCCCCCHHEEECCC	36.46	26074081
720	Phosphorylation	SPPLSKVSVIPHDLF CCCCHHEEECCCCCC	20.33	26074081
769	Phosphorylation	GYMPDLDSREEEADG CCCCCCCCCCCCCCC	49.22	24275569
779	Phosphorylation	EEADGSQSSSSSSVP CCCCCCCCCCCCCCC	33.61	30576142
780	Phosphorylation	EADGSQSSSSSSVPG CCCCCCCCCCCCCCC	26.97	30576142
784	Phosphorylation	SQSSSSSSVPGESLP CCCCCCCCCCCCCCC	33.99	30576142
807	Phosphorylation	LSRGGVGTTPASEPA ECCCCCCCCCCCCCC	27.48	23312004
808	Phosphorylation	SRGGVGTTPASEPAP CCCCCCCCCCCCCCC	15.78	28985074
811	Phosphorylation	GVGTTPASEPAPLAP CCCCCCCCCCCCCCC	45.37	23312004
827	Phosphorylation	EDHQQRETKENDPMD CHHHCCCCCCCCCCC	45.94	30624053
835	Phosphorylation	KENDPMDSHQSQESP CCCCCCCCCCCCCCC	19.71	30243723
838	Phosphorylation	DPMDSHQSQESPNLE CCCCCCCCCCCCCHH	30.41	30278072
841	Phosphorylation	DSHQSQESPNLENIA CCCCCCCCCCHHHHC	16.08	30278072
856	Phosphorylation	NPLEENVTKESISSK CHHHHCCCHHHHCHH	40.45	30243723
859	Phosphorylation	EENVTKESISSKKKE HHCCCHHHHCHHHHH	29.35	-
862	Phosphorylation	VTKESISSKKKEKRK CCHHHHCHHHHHHHC	46.99	-
884	Phosphorylation	SLFVAPGSVQSSDDL CEEECCCCCCCCCCC	18.87	28348404
887	Phosphorylation	VAPGSVQSSDDLEED ECCCCCCCCCCCCCC	33.31	28348404
888	Phosphorylation	APGSVQSSDDLEEDS CCCCCCCCCCCCCCC	20.32	28348404
904	Phosphorylation	DYSIPSRTSHSDSSI CCCCCCCCCCCCCCE	34.82	30108239
905	Phosphorylation	YSIPSRTSHSDSSIY CCCCCCCCCCCCCEE	21.63	26657352
907	Phosphorylation	IPSRTSHSDSSIYLR CCCCCCCCCCCEEEE	38.67	23911959
909	Phosphorylation	SRTSHSDSSIYLRRH CCCCCCCCCEEEEEC	22.96	30108239
910	Phosphorylation	RTSHSDSSIYLRRHT CCCCCCCCEEEEECC	21.90	30108239
912	Phosphorylation	SHSDSSIYLRRHTHR CCCCCCEEEEECCCC	8.98	30108239
920	Phosphorylation	LRRHTHRSSESDHFS EEECCCCCCCCCCCC	30.74	30278072
921	Phosphorylation	RRHTHRSSESDHFSY EECCCCCCCCCCCCE	40.87	25849741
923	Phosphorylation	HTHRSSESDHFSYVQ CCCCCCCCCCCCEEE	38.03	30278072
927	Phosphorylation	SSESDHFSYVQLRNA CCCCCCCCEEEEECC	22.45	28796482
928	Phosphorylation	SESDHFSYVQLRNAA CCCCCCCEEEEECCC	7.41	28796482

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CLMN_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CLMN_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CLMN_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of CLMN_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CLMN_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-402, AND MASSSPECTROMETRY.	18669648 [Abstract]