CLIP2_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CLIP2_RAT
• UniProt AC: O55156
• Protein Name: CAP-Gly domain-containing linker protein 2
• Gene Name: Clip2
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 1046
• Subcellular Localization: Cytoplasm . Cytoplasm, cytoskeleton . Localizes preferentially to the ends of tyrosinated microtubules.
• Protein Description: Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in bulbous dendritic appendages of neurons linked by dendrodendritic gap junctions. May operate in the control of brain-specific organelle translocations..
• Protein Sequence: MQKPSGLKPPGRGGKHSSPVGRPSIGSASSSVVASASGSKEGSPLHKQASGPSSAGATTTVSEKPGPKAAEVGDDFLGDFVVGERVWVNGVKPGVVQYLGETQFAPGQWAGVVLDDPVGKNDGAVGGLRYFECPALQGIFTRPSKLTRQPAAEGSGSDGHSVESLTAQNLSLHSGTATPPLTGRVIPLRESVLNSSVKTGNESGSNLSDSGSVKRGDKDLHLGDRVLVGGTKTGVVRYVGETDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCPPKFGLFAPIHKVIRIGFPSTSPAKAKKTKRMAMGVSALTHSPSSSSISSVSSVASSVGGRPSRSGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAEEKLQRARLLVENVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLETQTQLEHARIGELEQSLLLEKAQAERLLRELADNRLTTVAEKSRVLQLEEELSLRRGEIEELQHCLLQSGPPPADHPEAAETLRLRERLLSASKEHQRDSTLLQDKYEHMLKTYQTEVDKLRAANEKYAQEVADLKAKVQQATTENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQKEIGELKALVEGIKMEHQLELGNLQAKHDLETAMHGKEKEGLRQKLQEAQEELAGLQQHWRAQLEEQAAAPAELQEAQDQCRDAQLRVQELEGLDVEYRGQAQAIEFLKEQISLAEKKMLDYEMLQRAEAQSRQEAERLREKLLVAENRLQAVESLCSAQHSHVIESNDLSEEKIRMKETVEGLQDKLNKRDKEVAALTSQMDMLRAQVSALENKCKSGEKKIDSLLKEKRRLEAELEAVSRKTHDASGQLVHISQELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIKEQKLKDDIRGLREKLTGLDKEKSLSEQKRYSLIDPASAPELLRLQHQLVSTEGCLRDALDQAQQVERLVEALRGCSDRTQTISNSGSANGIHQPDKAHKQEDKH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
17	Phosphorylation	PGRGGKHSSPVGRPS CCCCCCCCCCCCCCC	39.56	23984901
18	Phosphorylation	GRGGKHSSPVGRPSI CCCCCCCCCCCCCCC	24.27	27097102
24	Phosphorylation	SSPVGRPSIGSASSS CCCCCCCCCCCCCCC	37.92	28432305
27	Phosphorylation	VGRPSIGSASSSVVA CCCCCCCCCCCCCHH	24.25	23984901
29	Phosphorylation	RPSIGSASSSVVASA CCCCCCCCCCCHHCC	25.50	23984901
30	Phosphorylation	PSIGSASSSVVASAS CCCCCCCCCCHHCCC	27.20	23984901
31	Phosphorylation	SIGSASSSVVASASG CCCCCCCCCHHCCCC	20.37	23984901
35	Phosphorylation	ASSSVVASASGSKEG CCCCCHHCCCCCCCC	16.03	27097102
37	Phosphorylation	SSVVASASGSKEGSP CCCHHCCCCCCCCCC	40.90	27097102
39	Phosphorylation	VVASASGSKEGSPLH CHHCCCCCCCCCCCC	25.66	27097102
43	Phosphorylation	ASGSKEGSPLHKQAS CCCCCCCCCCCCCCC	25.94	28432305
50	Phosphorylation	SPLHKQASGPSSAGA CCCCCCCCCCCCCCC	49.06	28432305
53	Phosphorylation	HKQASGPSSAGATTT CCCCCCCCCCCCCEE	36.02	27097102
54	Phosphorylation	KQASGPSSAGATTTV CCCCCCCCCCCCEEC	33.58	27097102
58	Phosphorylation	GPSSAGATTTVSEKP CCCCCCCCEECCCCC	23.29	27097102
59	Phosphorylation	PSSAGATTTVSEKPG CCCCCCCEECCCCCC	25.35	27097102
60	Phosphorylation	SSAGATTTVSEKPGP CCCCCCEECCCCCCC	20.06	27097102
62	Phosphorylation	AGATTTVSEKPGPKA CCCCEECCCCCCCCH	37.50	27097102
178	Phosphorylation	SLHSGTATPPLTGRV EECCCCCCCCCCCCE	25.85	30240740
191	Phosphorylation	RVIPLRESVLNSSVK CEEECCHHHHCCCCC	26.02	28432305
195	Phosphorylation	LRESVLNSSVKTGNE CCHHHHCCCCCCCCC	32.14	28432305
196	Phosphorylation	RESVLNSSVKTGNES CHHHHCCCCCCCCCC	26.93	28432305
199	Phosphorylation	VLNSSVKTGNESGSN HHCCCCCCCCCCCCC	42.98	28551015
203	Phosphorylation	SVKTGNESGSNLSDS CCCCCCCCCCCCCCC	52.07	27097102
205	Phosphorylation	KTGNESGSNLSDSGS CCCCCCCCCCCCCCC	43.83	27097102
208	Phosphorylation	NESGSNLSDSGSVKR CCCCCCCCCCCCCCC	33.70	23712012
210	Phosphorylation	SGSNLSDSGSVKRGD CCCCCCCCCCCCCCC	29.59	27097102
212	Phosphorylation	SNLSDSGSVKRGDKD CCCCCCCCCCCCCCC	28.54	27097102
293	Phosphorylation	VIRIGFPSTSPAKAK EHHCCCCCCCHHHCH	38.98	27097102
294	Phosphorylation	IRIGFPSTSPAKAKK HHCCCCCCCHHHCHH	38.68	27097102
295	Phosphorylation	RIGFPSTSPAKAKKT HCCCCCCCHHHCHHH	27.48	27097102
310	Phosphorylation	KRMAMGVSALTHSPS HHHHCCHHHHHCCCC	16.31	27097102
313	Phosphorylation	AMGVSALTHSPSSSS HCCHHHHHCCCCCCC	21.74	27097102
315	Phosphorylation	GVSALTHSPSSSSIS CHHHHHCCCCCCCCC	22.65	28689409
317	Phosphorylation	SALTHSPSSSSISSV HHHHCCCCCCCCCCH	45.96	27097102
318	Phosphorylation	ALTHSPSSSSISSVS HHHCCCCCCCCCCHH	31.33	27097102
319	Phosphorylation	LTHSPSSSSISSVSS HHCCCCCCCCCCHHH	35.71	27097102
320	Phosphorylation	THSPSSSSISSVSSV HCCCCCCCCCCHHHH	28.56	27097102
322	Phosphorylation	SPSSSSISSVSSVAS CCCCCCCCCHHHHHH	27.00	27097102
323	Phosphorylation	PSSSSISSVSSVASS CCCCCCCCHHHHHHH	25.09	27097102
325	Phosphorylation	SSSISSVSSVASSVG CCCCCCHHHHHHHCC	22.50	27097102
326	Phosphorylation	SSISSVSSVASSVGG CCCCCHHHHHHHCCC	21.39	27097102
329	Phosphorylation	SSVSSVASSVGGRPS CCHHHHHHHCCCCCC	24.33	27097102
330	Phosphorylation	SVSSVASSVGGRPSR CHHHHHHHCCCCCCC	18.29	27097102
336	Phosphorylation	SSVGGRPSRSGLLTE HHCCCCCCCCCCCCH	37.40	28689409
342	Phosphorylation	PSRSGLLTETSSRYA CCCCCCCCHHCHHHH	42.11	27097102
344	Phosphorylation	RSGLLTETSSRYARK CCCCCCHHCHHHHHH	27.11	27097102
345	Phosphorylation	SGLLTETSSRYARKI CCCCCHHCHHHHHHH	13.44	27097102
346	Phosphorylation	GLLTETSSRYARKIS CCCCHHCHHHHHHHH	36.41	27097102
353	Phosphorylation	SRYARKISGTTALQE HHHHHHHHCHHHHHH	32.87	20519438
355	Phosphorylation	YARKISGTTALQEAL HHHHHHCHHHHHHHH	11.34	27097102
356	Phosphorylation	ARKISGTTALQEALK HHHHHCHHHHHHHHH	28.97	27097102
454	Phosphorylation	QFRVEEESITKGDLE HHHHHHHCCCCCCCH	38.55	30181290
456	Phosphorylation	RVEEESITKGDLETQ HHHHHCCCCCCCHHH	37.95	30181290
552	Phosphorylation	RLRERLLSASKEHQR HHHHHHHHHCHHHHH	34.78	22108457
628	Phosphorylation	LASDHQKSLEDLKAT HHHHHHHHHHHHHHH	30.35	22673903
923	Phosphorylation	LLEANRHSPGPERDL HHHHCCCCCCCCCHH	28.45	27097102
972	Phosphorylation	SLSEQKRYSLIDPAS CCCHHHCHHCCCCCC	18.18	23984901
973	Phosphorylation	LSEQKRYSLIDPASA CCHHHCHHCCCCCCH	23.92	22108457
979	Phosphorylation	YSLIDPASAPELLRL HHCCCCCCHHHHHHH	50.15	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CLIP2_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CLIP2_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CLIP2_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CLAP1_MOUSE	Clasp1	physical	11290329

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.