CLIC5_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CLIC5_RAT
• UniProt AC: Q9EPT8
• Protein Name: Chloride intracellular channel protein 5
• Gene Name: Clic5
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 251
• Subcellular Localization: Golgi apparatus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Membrane; Single-pass membrane protein. Cytoplasm. Colocalized with AKAP9 at the Golgi apparatus as well as, to a lesser extent, the centrosome. Exists both as solub
• Protein Description: Required for normal hearing. It is necessary for the formation of stereocilia in the inner ear and normal development of the organ of Corti. Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. May play a role in the regulation of transepithelial ion absorption and secretion. Is required for the development and/or maintenance of the proper glomerular endothelial cell and podocyte architecture (By similarity)..
• Protein Sequence: MTDSATANGDDRDPEIELFVKAGIDGESIGNCPFSQRLFMILWLKGVVFNVTTVDLKRKPADLHNLAPGTHPPFLTFNGDVKTDVNKIEEFLEETLTPEKYPKLAARHRESNTAGIDIFSKFSAYIKNTKQQNNAALERGLTKALRKLDDYLNTPLPEEIDTNTHGDEKGSQRKFLDGDELTLADCNLLPKLHVVKIVAKKYRNYDIPAEMTGLWRYLKNAYARDEFTNTCAADSEIELAYADVARRLSRS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
59	Acetylation	TTVDLKRKPADLHNL EEECCCCCCCCCCCC	42.86	22902405
87	Acetylation	DVKTDVNKIEEFLEE CCCCCHHHHHHHHHH	51.87	22902405
100	Acetylation	EETLTPEKYPKLAAR HHHCCHHHHHHHHHH	68.97	22902405
103	Acetylation	LTPEKYPKLAARHRE CCHHHHHHHHHHHHC	47.90	22902405
147	Acetylation	GLTKALRKLDDYLNT HHHHHHHHHHHHHCC	58.06	22902405
169	Acetylation	TNTHGDEKGSQRKFL CCCCCCCCCCCCCCC	69.47	22902405
196	Acetylation	LPKLHVVKIVAKKYR CCCCEEEEEEEHHHC	30.30	22902405
196	Ubiquitination	LPKLHVVKIVAKKYR CCCCEEEEEEEHHHC	30.30	-
219	Acetylation	TGLWRYLKNAYARDE HHHHHHHHHHHHCCC	30.51	22902405

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CLIC5_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CLIC5_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CLIC5_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of CLIC5_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.