CLH_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CLH_SCHPO
• UniProt AC: Q10161
• Protein Name: Probable clathrin heavy chain
• Gene Name: chc1
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 1666
• Subcellular Localization: Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic face of coated pits and vesicles..
• Protein Description: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles..
• Protein Sequence: MAQQLPIRFSEVLQLASVGIQPSSFGFANVTLESDKYVCVRDNPNGVNQVVIVDLEDPSNVLRRPISADSVILHPKKKIIALKAQRQLQVFDLEAKAKINSYVMNQDVVYWTWISDSVIGMVTDTSVFHWTVSGSDPVKMFDRHSSLNGTQIISYKSNYNEEWFTLIGISSRDNRIAGNLQLYSKKRKVSQPLESHASAFAVIQPEGVDHEVQVLALASRLPTGSKLSIVEVDRNPNNPAFATKTVDLFFPPEAVNDFPIAIEIGSTYNVAYVVTKYGFIHVYDLETAKCIYMNRVSGESIFVTTAHKSVNGLMAINRKGQVLSVSINPETIIPYILSNLNDPGLAVRMASHANLPGADNLYMQQFQQLMAQGNYSEAAKVAASSPRGILRTSQVIDQFKLIQAAPGQIAPILQYFGTLLDKGPLNEHETIELARPVLAQNRIQLLEKWYGENKLACTEALGDLVKPYNTPFALKIYETANVPNKVVMCLSELGDFGKLATYTSQQNITPDYVSLLQNLVRVNPDQAAEFATQMFNSNPSINLEKIVDIFMSQNLVQQATAFLLDALKDDNPEHSHLQTRLLEINLINAPQVADAILGNQMFTHFDRAVIASLCERAGLVQRALELYDKPADIKRVIVHSNLLNPEWLMNYFSRFSPDEVYDYLREMLRSNLRQNLQIVVQIATRYSDLVGAQRIIEMFEKFKTFEGLYYYLGSIVNITEDPEVVYKYIQAACLMNQFTEVERICRDNNVYNPEKVKNLLKEAKLADQLPLILVCDRYDFVNDLVFYLFRNNMFQFIEIYVQRINPSKTPQVVGALLDIDCDEELVQNLLMSVVGQVPVDELVEEVERRNRLKLLLPYLESLLQSGSQDRAIYDALAKIYIDSNNNPEVFLKENNFYDTLTVGKYCEKRDPYLAFIAYEKGGNDTEIINLCNENSMFKQLARYLLKRSDSNLWSEVLQDSAYRRPLLDQVIATAVPESSDPEAVSIVVKALMEVDLPSQLIELLEKIVLQPSSFSENANLQNLLFLTAIKADKSRVMEYIDKLDKYDVDEIAEIAIENGLYEEAFRIYKIHNKHEQAMKVLVEDIVSLDRAQDYAETVEQPEVWSRLAKAQLDGIRIPDAIESYLKADDPSNYSEVIELASRAGKYEELIKYLLMARSKMHEPDVDSALLIAYAKTNQLTEMETFLIGSNVADVKAVGDECFESKNYEAAKLMYSSISNWSMLATTLVYLGEYQGAVDCARKANSIKVWKQVGTACIDKREFRLAQICGLNLIVHAEELPGLIRLYEERGYFEEVISLMEAGLGLERAHMAFYTELAILYAKYKPERMMEHLKLFWGRLNMAKVIRACDQMHLWNEAVFLYVHDQSYDNAAAVMMEQPEAFDHQSFKDIIVHVANLELYYRALNFYLEQHPMLLTDLLAALTPRIDHPRVIRIFEKSENTPLILNFMVAIQHLNIQAVNHAYNDLLIEMEDYQSLQDSIENYDHFDAIALARRLEKHSLLEFRRIAAYIYRKNKRWTQSIELSKQDRFYKDAIITARDSDQTTIAEDLMKYFVEIGNYECFAAILYTCYHLLRNDLVMEISWRKGLQDYAYPYFINFQCEMFSKVLNLEKDLKDRQAVKSEEESASTIGAGILGNTLMLTQGPMANNNDQFDSFQQASPMPRLGNF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
309	Phosphorylation	FVTTAHKSVNGLMAI EEEEECHHHCCEEEE	15.79	29996109
392	Phosphorylation	SPRGILRTSQVIDQF CCCHHCCHHHHHHHH	21.77	28889911
393	Phosphorylation	PRGILRTSQVIDQFK CCHHCCHHHHHHHHH	18.93	28889911
1640	Phosphorylation	LGNTLMLTQGPMANN HCCCEEEECCCCCCC	19.95	21712547
1653	Phosphorylation	NNNDQFDSFQQASPM CCCCCCCCHHHCCCC	26.66	29996109
1658	Phosphorylation	FDSFQQASPMPRLGN CCCHHHCCCCCCCCC	19.86	29996109

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CLH_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CLH_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CLH_SCHPO !!

Protein-Protein Interaction

Oops, there are no PPI records of CLH_SCHPO !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-392 AND SER-393, ANDMASS SPECTROMETRY.
PubMed: 18257517