CLD12_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CLD12_HUMAN
• UniProt AC: P56749
• Protein Name: Claudin-12
• Gene Name: CLDN12
• Organism: Homo sapiens (Human).
• Sequence Length: 244
• Subcellular Localization: Cell junction, tight junction. Cell membrane ; Multi-pass membrane protein .
• Protein Description: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity..
• Protein Sequence: MGCRDVHAATVLSFLCGIASVAGLFAGTLLPNWRKLRLITFNRNEKNLTVYTGLWVKCARYDGSSDCLMYDTTWYSSVDQLDLRVLQFALPLSMLIAMGALLLCLIGMCNTAFRSSVPNIKLAKCLVNSAGCHLVAGLLFFLAGTVSLSPSIWVIFYNIHLNKKFEPVFSFDYAVYVTIASAGGLFMTSLILFIWYCTCKSLPSPFWQPLYSHPPSMHTYSQPYSARSRLSAIEIDIPVVSHTT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
111	Phosphorylation	CLIGMCNTAFRSSVP HHHHHHHHHHHHCCC	23.42	-
115	Phosphorylation	MCNTAFRSSVPNIKL HHHHHHHHCCCCHHH	29.27	26657352
116	Phosphorylation	CNTAFRSSVPNIKLA HHHHHHHCCCCHHHH	37.02	26657352
121	Ubiquitination	RSSVPNIKLAKCLVN HHCCCCHHHHHHHHH	49.37	2190698
125	S-palmitoylation	PNIKLAKCLVNSAGC CCHHHHHHHHHHHHH	4.22	29575903
211	Phosphorylation	SPFWQPLYSHPPSMH CCCCCCHHCCCCCCC	16.18	-
216	Phosphorylation	PLYSHPPSMHTYSQP CHHCCCCCCCCCCCC	27.87	-
220	Phosphorylation	HPPSMHTYSQPYSAR CCCCCCCCCCCCCHH	7.22	-
228	Phosphorylation	SQPYSARSRLSAIEI CCCCCHHHHCCEEEE	36.97	30266825
231	Phosphorylation	YSARSRLSAIEIDIP CCHHHHCCEEEEEEC	26.53	23927012
241	Phosphorylation	EIDIPVVSHTT---- EEEECEEECCC----	18.49	23927012
243	Phosphorylation	DIPVVSHTT------ EECEEECCC------	27.05	23927012
244	Phosphorylation	IPVVSHTT------- ECEEECCC-------	31.05	23927012

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CLD12_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CLD12_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CLD12_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ECHM_HUMAN	ECHS1	physical	21988832
SEC13_HUMAN	SEC13	physical	21988832

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-231, AND MASSSPECTROMETRY.
PubMed: 19690332